Analyte sensor

• US 9,037,210 B2
• Filed: 01/17/2013
• Issued: 05/19/2015
• Est. Priority Date: 10/04/2006
• Status: Active Grant

• Current Assignee: DexCom Incorporated
• Original Assignee: DexCom Incorporated
• Inventors: Simpson, Peter C., Brister, Mark, Leach, Jacob S.
• Primary Examiner(s): D'Angelo, Michael
• Application Number:
  US13/743,452
• Publication Number:
  US 20130131469A1
• Time in Patent Office: 852 Days
• US Class Current: 600/345
• CPC Class Codes: A61B 2560/0223 of calibration, e.g. protocols for calibrating sensors
• CPC Class Codes: A61B 5/145 Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissuemeasuring of blood pressure or blood flow A61B5/02; non-radiation detecting or locating of foreign bodies in blood A61B5/06
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14539 for measuring pH
• CPC Class Codes: A61B 5/14542 for measuring blood gases A61B5/14551 takes precedence
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: A61B 5/412 Detecting or monitoring sepsis
• CPC Class Codes: A61B 5/6848 Needles
• CPC Class Codes: A61B 5/6849 in combination with a needle set
• CPC Class Codes: A61B 6/586 Detection of faults or malfunction of the device
• CPC Class Codes: A61M 2230/201 Glucose concentration
• CPC Class Codes: A61M 5/14 Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
• CPC Class Codes: A61M 5/16804 Flow controllers
• CPC Class Codes: C12Q 1/001 Enzyme electrodes
• CPC Class Codes: C12Q 1/006 for glucose
• CPC Class Codes: G16H 20/17 delivered via infusion or injection
• CPC Class Codes: G16H 40/40 for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
• CPC Class Codes: Y02A 90/10 Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Abstract

Systems and methods of use for continuous analyte measurement of a host'"'"'s vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host'"'"'s circulatory system.

Claims

1. A method for detecting a fluidics malfunction of an analyte sensor system in a circulatory system of a host, the method comprising:

providing an apparatus comprising an external surface, a first orifice and a second orifice, wherein at least one of the first orifice and the second orifice is configured to couple with a fluid flow device;

a lumen, at least one sensor disposed within the lumen of the apparatus;

contacting the at least one sensor with a plurality of samples from the circulatory system of a host; and

generating a signal from each of the at least one sensors for the plurality of samples;

detecting a fluidics malfunction by monitoring a pattern of signal increases or decreases generated from each of the at least one sensor from the plurality of samples; and

causing the analyte sensor system to activate a fail-safe mode upon detecting the fluidics malfunction, wherein the fail safe mode consists essentially of providing a visual and/or audio alert, an alarm, and/or an instruction to the host or a caretaker of the host, suspending temporarily or permanently a display of analyte sensor system data, updating calibration or re-calibrating the sensor, requesting external reference values, transmitting one or more messages to a user interface or other external source, or shutting down of the analyte sensor system.

2. The method of claim 1, further comprising processing the signals from each of the sensors.

3. The method of claim 1, wherein the generating step comprises at least one of electrochemically generating, optically generating, radiochemically generating, physically generating, chemically generating, immunochemically generating, and/enzymatically generating a signal from each of the plurality of sensors.

4. The method of claim 1, further comprising reinfusing the withdrawn sample into the host.

5. The method of claim 1, further comprising washing the sensors with an infusion fluid.

6. The method of claim 1, further comprising calibrating the signal of at least one of the sensors.