Delivery devices

• US 9,038,630 B2
• Filed: 11/28/2007
• Issued: 05/26/2015
• Est. Priority Date: 11/28/2006
• Status: Active Grant

• Current Assignee: OptiNose, Inc.
• Original Assignee: OptiNose AS (OptiNose, Inc.)
• Inventors: Djupesland, Per Gisle, Gaarder, Rune Harald, Lamolle, Sbastien
• Primary Examiner(s): Ho, Tan-Uyen (Jackie) T
• Assistant Examiner(s): Heffner, Ned T
• Application Number:
  US12/516,399
• Publication Number:
  US 20110126830A1
• Time in Patent Office: 2,736 Days
• Field of Search: 128/203.15, 128/203.23, 128/203.12, 12820011-20023, 12820318-20322
• US Class Current: 128/203.18
• CPC Class Codes: A61M 15/0021 Mouthpieces therefor
• CPC Class Codes: A61M 15/0023 retractable
• CPC Class Codes: A61M 15/0028 using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
• CPC Class Codes: A61M 15/0035 Piercing means
• CPC Class Codes: A61M 15/0041 with movable piercing or cutting means
• CPC Class Codes: A61M 15/0098 Activated by exhalation
• CPC Class Codes: A61M 15/08 Inhaling devices inserted into the nose
• CPC Class Codes: A61M 2202/04 Liquids
• CPC Class Codes: A61M 2202/064 Powder
• CPC Class Codes: A61M 2205/073 Syringe, piston type
• CPC Class Codes: A61M 2206/16 Rotating swirling helical flow, e.g. by tangential inflows

Abstract

A delivery device for delivering a metered amount of substance, the delivery device comprising: a mouthpiece (17) through which a user in use exhales; an outlet (19) through which substance is in use delivered; a housing (21) fluidly connected to the mouthpiece and the outlet, such, that exhalation by the user through the mouthpiece creates an air flow through the housing and from the outlet; and a substance-dispensing unit (25) which is disposed within the housing and operative to dispense a metered amount of substance into an entraining air flow as created through the housing.

Claims

1. A delivery device for delivering a metered amount of a powdered substance, the delivery device comprising:

a mouthpiece through which a user in use exhales;

an outlet through which substance is in use delivered;

a housing fluidly connected to the mouthpiece and the outlet, such that exhalation by the user through the mouthpiece creates an air flow through the housing and from the outlet; and

a substance-dispensing unit which is disposed within the housing and operative to dispense a metered amount of a powdered substance into an entraining air flow as created through the housing, wherein the substance-dispensing unit includes a baffle which extends across a longitudinal axis of the housing and separates the housing to define an inlet cavity which is upstream of the baffle and an outlet cavity which is downstream of the baffle, wherein the inlet and outlet cavities are located to opposite sides of the baffle in longitudinal relation to a longitudinal extent of the longitudinal axis of the housing, and the baffle supports a container for containing substance which includes an opening which in use opens to the outlet cavity, with the baffle including at least one entraining air flow channel which is disposed adjacent the container and provides a fluid communication path between the inlet and outlet cavities to provide for delivery of at least one entraining air flow adjacent the opening of the container which entrains substance when dispersed from the container, and at least one dispersion air flow channel which is configured to provide for at least one dispersing air flow into the container in a direction opposite the at least one entraining air flow to disperse the substance from the container and into the at least one entraining air flow as generated through the at least one entraining air flow channel.

2. The delivery device of claim 1, wherein the at least one dispersion air flow channel provides for delivery of at least one dispersing air flow at an angle inclined in a vertical orient relative to the opening of the container.

3. The delivery device of claim 1, wherein the at least one dispersion air flow channel provides for delivery of the at least one dispersing air flow with a tangential component in a horizontal orient relative to the opening of the container.

4. The delivery device of claim 1, wherein the substance-dispensing unit includes a sleeve which is disposed in the outlet cavity to define a delivery chamber through which the at least one entraining air flow is in use delivered to the outlet.

5. The delivery device of claim 1, wherein the outlet is a nosepiece and the delivery device is a nasal delivery device for delivering substance to the nasal airway of the user.

6. The delivery device of claim 1, wherein the baffle includes a plurality of entraining air flow channels which are disposed about the periphery of the container.

7. The delivery device of claim 6, wherein the entraining air flow channels are configured to provide substantially parallel air flows.

8. The delivery device of claim 6, wherein the entraining air flow channels are configured to provide converging air flows which converge at a location over the opening to the container.

9. The delivery device of claim 6, wherein the entraining air flow channels are arranged on an annulus surrounding the container.

10. The delivery device of claim 9, wherein the entraining air flow channels are arranged symmetrically.

11. The delivery device of claim 1, wherein the baffle includes first and second dispersion air flow channels.

12. The delivery device of claim 11, wherein the first and second dispersion air flow channels are disposed to opposite sides of the container.

13. The delivery device of claim 11, wherein the first and second dispersion air flow channels are non-symmetrically arranged.

14. The delivery device of claim 13, wherein the first and second dispersion air flow channels are configured to provide for dispersing air flows which are inclined at different angles in a vertical orient relative to the opening of the container.

15. The delivery device of claim 1, wherein the substance-dispensing unit includes a sleeve which is disposed in the outlet cavity to define a delivery chamber through which the at least one entraining air flow is in use delivered to the outlet, and the sleeve further defines a reservoir chamber which is fluidly connected to the inlet cavity and the at least one dispersion air flow channel.

16. The delivery device of claim 15, wherein the reservoir chamber is an annular chamber which surrounds at least in part the delivery chamber.