Quantitative, non-invasive, clinical diagnosis of traumatic brain injury using VOG device for neurologic optokinetic testing

• US 9,039,632 B2
• Filed: 07/21/2014
• Issued: 05/26/2015
• Est. Priority Date: 10/09/2008
• Status: Active Grant

• Current Assignee: Spryson Incorporated
• Original Assignee: Neuro Kinetics, Inc. (Neurolign Technologies, Inc.)
• Inventors: Kiderman, Alexander D, Schroeder, Howison, Joos, Thomas, Frank, Greg, Sweeney, Daniel, Baker, Thomas Vernon
• Primary Examiner(s): HINDENBURG, MAX F
• Application Number:
  US14/336,254
• Publication Number:
  US 20140327880A1
• Time in Patent Office: 309 Days
• Field of Search: 600/558, 600/587
• US Class Current: 600/558
• CPC Class Codes: A61B 3/0041 characterised by display arrangements
• CPC Class Codes: A61B 3/02 Subjective types, i.e. testing apparatus requiring the active assistance of the patient
• CPC Class Codes: A61B 3/032 Devices for presenting test symbols or characters, e.g. test chart projectors A61B3/036 takes precedence
• CPC Class Codes: A61B 3/113 for determining or recording eye movement
• CPC Class Codes: A61B 5/16 Devices for psychotechnics using teaching or educational appliances G09B1/00 - G09B7/00; Testing reaction times ; Devices for evaluating the psychological state
• CPC Class Codes: A61B 5/163 by tracking eye movement, gaze, or pupil change
• CPC Class Codes: A61B 5/4064 Evaluating the brain A61B5/031, A61B5/369, A61B5/14553 take precedence
• CPC Class Codes: A61B 5/4863 Measuring or inducing nystagmus
• CPC Class Codes: A61B 5/6803 Head-worn items, e.g. helmets, masks, headphones or goggles
• CPC Class Codes: G02B 2027/0138 comprising image capture systems, e.g. camera
• CPC Class Codes: G02B 2027/014 comprising information/image processing systems
• CPC Class Codes: G02B 2027/0187 slaved to motion of at least a part of the body of the user, e.g. head, eye
• CPC Class Codes: G02B 27/0093 with means for monitoring data relating to the user, e.g. head-tracking, eye-tracking
• CPC Class Codes: G02B 27/017 Head mounted
• CPC Class Codes: G02C 5/001 specially adapted for particular purposes, not otherwise provided for or not fully classifiable according to technical characteristics, e.g. therapeutic glasses

Abstract

A portable VOG device is disclosed that will facilitate the effective and efficient screening for TBI in military personnel in forward deployed military settings or remote locations using minimally trained staff. This includes the establishment of a protocol including optokinetic testing that will provide cost effective pre-screening of military personnel prior to deployment to establish a baseline of brain function prior to possible future injury. The efficiency of the device will promote subsequent follow-up screening to assess the effectiveness of prescribed TBI treatment. Further protocols for diagnosis and rehabilitation applications using the same device will allow more advanced usage for clinicians providing ongoing evaluation and treatment.

Claims

1. A method of diagnosis of traumatic brain injury or concussion in a subject comprising the steps of:

A) providing a system including a stimulus generating portion and an eye tracking portion;

B) presenting visual stimulus to the subject via the stimulus generating portion, wherein the visual stimulus presented to the subject via the stimulus generating portion forms the optical target stimulus for at least one optokinetic test;

C) obtaining objective physiologic response of the subject in the form of reflexive ocular-motor responses of the subject'"'"'s eyes from the eye tracking portion based upon each of the visual stimulus presented to the subject in each optokinetic test; and

D) using the objective physiologic responses including the reflexive ocular-motor responses of the subject'"'"'s eyes to the optical target stimulus of each optokinetic test to diagnose the presence of traumatic brain injury.

2. The method of diagnosis of traumatic brain injury according to claim 1, further including the step of obtaining pre-trauma objective physiologic responses of the subject from based upon each of the visual stimulus presented to the subject for each optokinetic test, wherein the pre-trauma objective physiologic responses for each optokinetic test form a baseline for the subject.

3. The method of diagnosis of traumatic brain injury according to claim 2, wherein the step of using the objective physiologic responses to diagnose the presence of traumatic brain injury includes a determining whether at least one post-trauma objective physiologic responses of the subject differs from the associated pre-trauma objective physiologic response by greater than a preset threshold for that response.

4. The method of diagnosis of traumatic brain injury according to claim 1, wherein the step of using the objective physiologic responses to diagnose the presence of traumatic brain injury includes a determining whether at least one post-trauma objective physiologic responses of the subject for each optokinetic test differs from an associated objective physiologic response of a normative database of similar subjects for each optokinetic test by greater than a preset threshold for that response.

5. A method of diagnosis of traumatic brain injury in a subject comprising the steps of:

A) providing a head mounted stimulus generating eye tracking goggle unit coupled to the subject and generating a plurality of visual stimulus for the subject;

B) presenting the plurality of visual stimulus to the subject, wherein each visual stimulus is presented in the eye tracking unit, wherein each visual stimulus provides a target stimulus for a distinct visual based neurologic optokinetic test;

C) obtaining objective physiologic response of the subject from the eye tracking unit in the form of reflexive ocular-motor responses of the subiect'"'"'s eyes based upon each of neurologic optokinetic test associated with each visual stimulus presented to the subject; and

D) using the objective physiologic responses to the neurologic optokinetic tests including the reflexive ocular-motor responses of the subiect'"'"'s eyes to the optical target stimulus to diagnose the presence of traumatic brain injury.

6. The method of diagnosis of traumatic brain injury according to claim 5, wherein the step of using the objective physiologic responses to diagnose the presence of traumatic brain injury includes a determining whether at least one post-trauma objective physiologic responses of the subject for each optokinetic test differs from an associated objective physiologic response of a normative database of similar subjects for each optokinetic test by greater than a preset threshold for that response.

7. The method of diagnosis of traumatic brain injury according to claim 5, further including the step of obtaining pre-trauma objective physiologic responses of the subject for each optokinetic test from the head mounted goggle unit based upon each of the visual stimulus presented to the subject for each optokinetic test, wherein the pre-trauma objective physiologic responses for each optokinetic test form a baseline for the subject.

8. The method of diagnosis of traumatic brain injury according to claim 7, wherein the step of using the objective physiologic responses to diagnose the presence of traumatic brain injury includes a determining whether at least one post-trauma objective physiologic responses of the subject differs from the associated pre-trauma objective physiologic response by greater than a preset threshold for that response.