Sample container with sensor receptacle and methods of use

• US 9,040,000 B2
• Filed: 01/26/2012
• Issued: 05/26/2015
• Est. Priority Date: 01/26/2012
• Status: Expired due to Fees

• Current Assignee: Heatflow Technologies Inc.
• Original Assignee: Heatflow Technologies Inc.
• Inventors: Dinges, Warren L.
• Primary Examiner(s): Warden, Jill
• Assistant Examiner(s): TAVARES, JULIE L
• Application Number:
  US13/358,932
• Publication Number:
  US 20130195139A1
• Time in Patent Office: 1,216 Days
• Field of Search: 374/200, 374/209, 702/130, 702/132, 422/500, 422/547, 422/549, 422/551, 422/556
• US Class Current: 422/550
• CPC Class Codes: B01L 2200/141 Preventing contamination, tampering
• CPC Class Codes: B01L 2200/147 Employing temperature sensors
• CPC Class Codes: B01L 2300/042 Caps; Plugs
• CPC Class Codes: B01L 2300/047 Additional chamber, reservoir
• CPC Class Codes: B01L 2300/0851 Bottom walls
• CPC Class Codes: B01L 2300/12 Specific details about materials
• CPC Class Codes: B01L 3/50825 Closing or opening means, corks, bungs closures for containers B65D; means for removing stoppers B67B7/02
• CPC Class Codes: B01L 7/52 with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples amplification or hybridisation processes per se C12Q1/68; controlling sequential reactions for synthesis B01J19/0046
• CPC Class Codes: G01K 1/08 Protective devices, e.g. casings
• CPC Class Codes: G01K 13/00 Thermometers specially adapted for specific purposes

Abstract

Devices and methods are described herein that are configured for use in laboratory testing, such as, for example, during a procedure including the monitoring and detection of chemical reactions. For example, the systems and devices described herein can be used during a procedure to monitor and detect polymerase chain reactions (PCR). In some embodiments, a sample container includes a container body that defines an interior volume and has an open end in fluid communication with the interior volume. A cap is sealingly engageable with the open end of the container body. The cap defines a receptacle that is configured to extend within a portion of the interior volume of the container body when the cap is sealingly engaged thereto. The receptacle can receive therein a sensor, such as, a temperature sensor that can monitor the temperature of a sample material disposed within the container body.

Claims

1. A sample container, comprising:

a container body defining an interior volume and having a first end defining an opening in fluid communication with the interior volume and a second end opposite the first end, the second end of the container body defining a receptacle extending towards the first end,

the receptacle having a closed end, an open end, a tapered portion at the open end configured to guide insertion of a temperature sensor into the receptacle and a substantially constant diameter portion between the tapered portion and the closed end.

2. The sample container of claim 1, wherein the interior volume is a first interior volume, the opening is a first opening, the receptacle being a first receptacle, the container body defining a second interior volume, a second opening in fluid communication with the second interior volume, and a second receptacle, the sample container further comprising:

a cap including a first cap portion and a second cap portion, the first cap portion being sealingly enagageable with the first opening of the container body, the second cap portion being sealingly engageable with the second opening of the container body.

3. The sample container of claim 1, wherein the container body is formed with a thermally conductive material.

4. The sample container of claim 1, further comprising:

a temperature sensor configured to be received within the receptacle.

5. The sample container of claim 1, wherein the closed end of the receptacle is disposed at substantially a center point of the interior region of the container body.

6. The sample container of claim 1, wherein the substantially constant diameter portion of the receptacle has an aspect ratio defined by a ratio of a length to a width of an inner diameter of the substantially constant diameter portion of the receptacle of at least 1.5:

1.

7. The sample container of claim 1, wherein the substantially constant diameter portion of the receptacle has a first length and the tapered portion has a second length substantially the same as the first length.