Methods, devices, kits and compositions for detecting roundworm, whipworm, and hookworm
First Claim
1. A method of detecting the presence or absence of one or more helminthic antigens in a sample, the method comprising contacting a sample from a mammal with:
- (a) a first antibody capable of specifically binding a roundworm coproantigen, but not a whipworm coproantigen;
(b) a second antibody capable of specifically binding a whipworm coproantigen, but not a roundworm coproantigen;
(c) forming antibody-coproantigen complexes in the presence of the coproantigens, if any, in the sample; and
(d) detecting the presence or absence of the antibody-coproantigen complexes, if any.
3 Assignments
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Accused Products
Abstract
Methods, devices, kits and compositions for detecting the presence or absence of one or more helminthic coproantigens in a sample are disclosed herein. The methods, devices, kits and compositions of the present invention may be used to confirm the presence or absence of roundworm, whipworm and/or hookworm in a fecal sample from a mammal and may also be able to distinguish between one or more helminth infections. Confirmation of the presence or absence of roundworm, whipworm and/or hookworm in the mammal may be made, for example, for the purpose of selecting an optimal course of treating the mammal and/or for the purpose of determining whether the mammal has been rid of the infection after treatment has been initiated.
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Citations
23 Claims
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1. A method of detecting the presence or absence of one or more helminthic antigens in a sample, the method comprising contacting a sample from a mammal with:
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(a) a first antibody capable of specifically binding a roundworm coproantigen, but not a whipworm coproantigen; (b) a second antibody capable of specifically binding a whipworm coproantigen, but not a roundworm coproantigen; (c) forming antibody-coproantigen complexes in the presence of the coproantigens, if any, in the sample; and (d) detecting the presence or absence of the antibody-coproantigen complexes, if any. - View Dependent Claims (4, 5, 6, 7, 9, 10, 11, 13, 14, 15, 16, 17, 18, 19, 20)
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2. A method of detecting the presence or absence of one or more helminthic antigens in a sample, the method comprising contacting a sample from a mammal with:
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(a) a first antibody capable of specifically binding a roundworm coproantigen, but not a hookworm coproantigen; (b) a second antibody capable of specifically binding a hookworm coproantigen, but not a roundworm coproantigen; (c) forming antibody-coproantigen complexes in the presence of the coproantigens, if any, in the sample; and (d) detecting the presence or absence of the antibody-coproantigen complexes, if any. - View Dependent Claims (8, 12)
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3. A method of detecting the presence or absence of one or more helminthic antigens in a sample, the method comprising contacting a sample from a mammal with:
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(a) a first antibody capable of specifically binding a whipworm coproantigen, but not a hookworm coproantigen; (b) a second antibody capable of specifically binding a hookworm coproantigen, but not a whipworm coproantigen; (c) forming antibody-coproantigen complexes in the presence of the coproantigens, if any, in the sample; and (d) detecting the presence or absence of the antibody-coproantigen complexes, if any.
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21. A method of diagnosing whether a mammal is infected with one or more parasitic worms, the method comprising the steps of:
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(a) contacting a sample from a mammal with; (i) a first antibody capable of specifically binding a roundworm coproantigen, but not a whipworm coproantigen; and (ii) a second antibody capable of specifically binding a whipworm coproantigen, but not a roundworm coproantigen; (b) forming antibody-coproantigen complexes in the presence of the coproantigens, if any, in the sample; (c) detecting the presence or absence of the antibody-coproantigen complexes, if any; and (d) diagnosing the mammal as having; (i) a roundworm infection if a roundworm antibody-coproantigen complex is present; and (ii) a whipworm infection if a whipworm antibody-coproantigen complex is present.
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22. A method of diagnosing whether a mammal is infected with one or more parasitic worms, the method comprising the steps of:
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(a) contacting a sample from a mammal with; (i) a first antibody capable of specifically binding a roundworm coproantigen, but not a hookworm coproantigen; (ii) a second antibody capable of specifically binding a hookworm coproantigen, but not a roundworm coproantigen; (b) forming antibody-coproantigen complexes in the presence of the coproantigens, if any, in the sample; (c) detecting the presence or absence of the antibody-coproantigen complexes, if any; and (d) diagnosing the mammal as having; (i) a roundworm infection if a roundworm antibody-coproantigen complex is present; and (ii) a hookworm infection if a hookworm antibody-coproantigen complex is present.
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23. A method of diagnosing whether a mammal is infected with one or more parasitic worms, the method comprising the steps of:
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(a) contacting a sample from a mammal with; (i) a first antibody capable of specifically binding a whipworm coproantigen, but not a hookworm coproantigen; (ii) a second antibody capable of specifically binding a hookworm coproantigen, but not a whipworm coproantigen; (b) forming antibody-coproantigen complexes in the presence of the coproantigens, if any, in the sample; (c) detecting the presence or absence of the antibody-coproantigen complexes, if any; and (d) diagnosing the mammal as having; (i) a whipworm infection if a whipworm antibody-coproantigen complex is present; and (ii) a hookworm infection if a hookworm antibody-coproantigen complex is present.
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Specification