Interaction control of cationic biocides using labile anionic polyelectrolytes

• US 9,040,510 B2
• Filed: 03/25/2009
• Issued: 05/26/2015
• Est. Priority Date: 04/03/2008
• Status: Active Grant

• Current Assignee: Alcon Incorporated
• Original Assignee: Alcon Research Limited (Nestle SA)
• Inventors: Ketelson, Howard Allen, Desousa, Ryan, Dassanayake, Nissanke L., Luck, Mary E.
• Primary Examiner(s): Rao, Savitha
• Assistant Examiner(s): Polansky, Gregg
• Application Number:
  US12/410,513
• Publication Number:
  US 20090253800A1
• Time in Patent Office: 2,253 Days
• US Class Current: 514/183
• CPC Class Codes: A61L 12/14 Organic compounds not covered by groups A61L12/10 or A61L12/12
• CPC Class Codes: A61L 12/143 Quaternary ammonium compounds
• CPC Class Codes: A61L 12/145 Polymeric quaternary ammonium compounds

Abstract

Methods of inhibiting the uptake of cationic biocides into medical devices such as contact lenses and implants are described. Methods of stabilizing emulsions containing cationic biocides are also described. In particular, the present invention provides for the use of polymers acting as labile anionic polyelectrolytes to reversibly bind cationic biocides. The reversible binding can reduce the deleterious effects of cationic biocides while maintaining biocidal activity. Preferred polymers include galactomannan and polyvinyl alcohol.

Claims

1. A method of using a galactomannan to inhibit uptake of a cationic biocide into hydrogel biomaterials, the method comprising adding to a composition containing a cationic biocide and a borate a galactomannan in an amount to form a concentration between 0.025 to 0.074% w/v, wherein the composition is adapted for use with hydrogel biomaterials.

2. A method according to claim 1, wherein the pH of the composition is greater than 7.

3. A method according to claim 1, wherein the galactomannan is hydroxypropyl guar.

4. A method according to claim 3, wherein the concentration of hydroxypropyl guar is 0.05%.

5. A method according to claim 1, wherein the cationic biocide is a polymeric quaternary ammonium compound.

6. A method according to claim 5, wherein the polymeric quaternary ammonium compound is polyquaternium-1.

16. A method according to claim 1, wherein the hydrogel biomaterial is a soft contact lens.

7. A method of reversibly binding cationic biocides in solution to inhibit uptake of the biocide into hydrogel biomaterials, the method comprising adding hydroxypropyl guar in an amount to form a concentration between 0.025 to 0.074% w/v to a composition containing a cationic biocide and a borate.

8. A method according to claim 7, wherein the pH of the composition is greater than 7.

9. A method according to claim 8, wherein the pH of the composition is not greater than 8.

10. A method according to claim 7, wherein the cationic biocide is a polymeric quaternary ammonium compound.

11. A method according to claim 10, wherein the polymeric quaternary ammonium compound is polyquaternium-1.

12. A method according to claim 8, wherein the cationic biocide is a polymeric quaternary ammonium compound.

13. A method according to claim 12, wherein the polymeric quaternary ammonium compound is polyquaternium-1.

14. A method according to claim 13, wherein the concentration of hydroxypropyl guar is about 0.05 w/v %.

15. A method according to claim 7, wherein the concentration of hydroxypropyl guar is about 0.05 w/v %.