Microscopy imaging
First Claim
Patent Images
1. An apparatus comprising:
- an imaging device to image a specimen that is a liquid or is in a liquid, or both, the imaging device havinga chamber to hold the liquid, andan integrated circuit comprising a two-dimensional array of photosensitive elements having a surface at which at least a million photosensitive elements are exposed to receive light of a predetermined wavelength or wavelength band that originates at or is reflected from, or both, the specimen within the chamber and reaches the photosensitive elements, without passing through an optical lens, along optical paths from points of reflection or origination or both of the specimen, at least some of the optical paths being equal to or less than 10 times the predetermined wavelength or the shortest wavelength in the predetermined wavelength band the pixel size of the photosensitive elements having a longest dimension of 5 microns or smaller; and
readout circuitry to perform one or more read outs of signals from the photosensitive elements of the two-dimensional array, each of the read outs representing, without computational image derivation, an image of the specimen that has a resolution and extent corresponding to the pixel size and the number of photosensitive elements in the array.
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Abstract
Among other things, an imaging device has a photosensitive array of pixels, and a surface associated with the array is configured to receive a specimen with at least a part of the specimen at a distance from the surface equivalent to less than about half of an average width of the pixels.
130 Citations
67 Claims
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1. An apparatus comprising:
an imaging device to image a specimen that is a liquid or is in a liquid, or both, the imaging device having a chamber to hold the liquid, and an integrated circuit comprising a two-dimensional array of photosensitive elements having a surface at which at least a million photosensitive elements are exposed to receive light of a predetermined wavelength or wavelength band that originates at or is reflected from, or both, the specimen within the chamber and reaches the photosensitive elements, without passing through an optical lens, along optical paths from points of reflection or origination or both of the specimen, at least some of the optical paths being equal to or less than 10 times the predetermined wavelength or the shortest wavelength in the predetermined wavelength band the pixel size of the photosensitive elements having a longest dimension of 5 microns or smaller; and readout circuitry to perform one or more read outs of signals from the photosensitive elements of the two-dimensional array, each of the read outs representing, without computational image derivation, an image of the specimen that has a resolution and extent corresponding to the pixel size and the number of photosensitive elements in the array. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66)
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67. An apparatus comprising:
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a high resolution portable microscope to image a specimen of blood, the imaging device having a chamber to hold the blood specimen, a two-dimensional array of photosensitive elements having a surface exposed to the blood specimen within the chamber, the spacing of the photosensitive elements having a longest dimension of 5 microns or smaller, the chamber and the two-dimensional array being arranged so that light of a predetermined wavelength or wavelength band that originates at or is reflected from, or both, the blood specimen reaches the photosensitive elements along optical paths from points of reflection or origination or both of the blood specimen that are equal to or less than 10 times the predetermined wavelength or the shortest wavelength in the predetermined wavelength band; and readout circuitry to perform a readout of signals from the photosensitive elements of the two-dimensional array, the readout representing, without computational image derivation, an image of the blood specimen that has a resolution corresponding to the pixel size and the number of the photosensitive elements in the array, and a portable housing containing the chamber, the two-dimensional array, and the readout circuitry, the portable housing being no larger than a laptop.
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Specification