Analyte sensors comprising hydrogel membranes
First Claim
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1. An electrode comprising:
- a sensing layer;
a first membrane disposed over the sensing layer, wherein the first membrane is a flux limiting membrane; and
a second membrane disposed over the flux limiting membrane, wherein the second membrane is a biocompatible membrane which comprises a hydrogel, a crosslinker, and a swelling modulator comprising a 3-arm epoxide sufficient to decrease or eliminate an early signal attenuation effect by the electrode.
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Abstract
Generally, embodiments of the present disclosure relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have improved signal response and stability by inclusion of a coating including a hydrogel, a crosslinker, and a swelling modulator, where the coating is disposed proximate to a working electrode of in vivo and/or in vitro analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.
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Citations
24 Claims
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1. An electrode comprising:
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a sensing layer; a first membrane disposed over the sensing layer, wherein the first membrane is a flux limiting membrane; and a second membrane disposed over the flux limiting membrane, wherein the second membrane is a biocompatible membrane which comprises a hydrogel, a crosslinker, and a swelling modulator comprising a 3-arm epoxide sufficient to decrease or eliminate an early signal attenuation effect by the electrode. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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Specification