Biopsy marker with in situ-generated imaging properties

• US 9,042,965 B2
• Filed: 03/06/2013
• Issued: 05/26/2015
• Est. Priority Date: 12/18/2006
• Status: Active Grant

• Current Assignee: C.R. Bard, Inc. (Becton, Dickinson & Co)
• Original Assignee: C.R. Bard, Inc. (Becton, Dickinson & Co)
• Inventors: Talpade, Dnyanesh A., Pathak, Chandrashekhar
• Primary Examiner(s): Le, Long V
• Assistant Examiner(s): Negarestan, Farshad
• Application Number:
  US13/787,331
• Publication Number:
  US 20130184562A1
• Time in Patent Office: 811 Days
• Field of Search: 600/424, 600/431, 600/414, 600/426, 424/423
• US Class Current: 600/431
• CPC Class Codes: A61B 10/02 Instruments for taking cell samples or for biopsy A61B10/0038 and A61B10/0045 take precedence; needle locating or guiding means A61B17/3403; samplers for enzymology or microbiology C12M1/26; sampling or preparing biological specimens G01N33/48
• CPC Class Codes: A61B 2090/3908 Soft tissue, e.g. breast tissue
• CPC Class Codes: A61B 2090/392 Radioactive markers
• CPC Class Codes: A61B 2090/3925 ultrasonic
• CPC Class Codes: A61B 2090/3966 Radiopaque markers visible in an X-ray image
• CPC Class Codes: A61B 2090/3995 Multi-modality markers
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: A61B 5/062 using magnetic field
• CPC Class Codes: A61B 5/064 using markers A61B5/062 takes precedence
• CPC Class Codes: A61B 6/12 Arrangements for detecting or locating foreign bodies
• CPC Class Codes: A61B 8/0833 involving detecting or locating foreign bodies or organic structures
• CPC Class Codes: A61B 90/39 Markers, e.g. radio-opaque or breast lesions markers
• CPC Class Codes: A61F 2250/0098 radio-opaque, e.g. radio-opaque markers
• CPC Class Codes: A61K 49/0002 General or multifunctional contrast agents, e.g. chelated agents
• CPC Class Codes: A61K 49/0409 Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
• CPC Class Codes: A61K 49/18 characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
• CPC Class Codes: A61K 49/222 characterised by a special physical form, e.g. emulsions, liposomes

Abstract

An intracorporeal marker, for marking a site within living tissue of a host, includes an outer body portion of biodegradable material. An inner body portion is located in the outer body portion. The inner body portion includes biological material that becomes calcified in the living tissue of the host over time. An agent interacts with the biological material to promote calcification of the biological material of the inner body portion in the living tissue of the host.

Claims

1. An intracorporeal marker for marking a site within living tissue of a host, the intracorporeal marker comprising:

an outer body portion of biodegradable material;

an inner body portion located in the outer body portion, the inner body portion configured to include elastin that becomes calcified in the living tissue of the host over time; and

an agent configured to interact with the elastin to promote calcification of the elastin of the inner body portion in the living tissue of the host, wherein the agent is selected from a group consisting of bone growth factor, phospholipids, and polyethylene glycol.

2. The marker of claim 1, wherein the biological material inner body portion includes porcine aortic wall tissue.

3. The marker of claim 1, wherein the elastin has been cross-linked.

4. The marker of claim 1, wherein the inner body portion is entirely encased within the outer body portion, and the outer body portion is porous.

5. The marker of claim 1, wherein the outer body portion includes collagen.

6. The marker of claim 1, wherein the outer body portion is a porous gelatin.

8. The marker of claim 6, wherein the outer body portion is configured to be detectable by ultrasound over a first time period and the inner body portion is configured to undergo calcification to be detectable by X-ray or MRI prior to the expiration of the first time period.

7. An intracorporeal marker for marking a site within living tissue of a host, the intracorporeal marker comprising:

an outer body portion of biodegradable material configured to be ultrasound detectable;

an inner body portion located in the outer body portion, the inner body portion including elastin configured to calcify in the living tissue of the host over a period of time to enhance X-ray or MRI detectability of the inner body portion; and

an agent configured to interact with the elastin to promote calcification of the elastin of the inner body portion in the living tissue of the host, wherein the agent is selected from a group consisting of bone growth factor, phospholipids, and polyethylene glycol.

9. The marker of claim 7, wherein the inner body portion is entirely encased within the outer body portion, and the outer body portion is porous.

10. The marker of claim 7, wherein the with elastin has been cross-linked.

11. The marker of claim 7, wherein the inner body portion includes porcine aortic wall tissue.

12. The marker of claim 7, wherein the outer body portion includes porous collagen.

13. The marker of claim 7, wherein the outer body portion is a porous gelatin.

14. An intracorporeal marker for marking a site within living tissue of a human host, the intracorporeal marker comprising:

an outer body portion of biodegradable material;

an inner body portion located within the outer body portion, the inner body portion including elastin configured to calcify in the living tissue of the human host over time; and

an additive that interacts with the elastin to promote calcification of the elastin in the living tissue of the human host, wherein the additive is selected from a group consisting of bone growth factor, phospholipids, and polyethylene glycol.

15. The marker of claim 14, wherein the inner body portion is entirely encased within the outer body portion, and the outer body portion is porous.

16. The marker of claim 14, wherein the biodegradable material of the outer body portion of is one of collagen foam or gelatin foam, and the elastin is embedded in the outer body portion.