Device and method for wound imaging and monitoring
First Claim
Patent Images
1. A portable, handheld device for outputting a representation of a wound in tissue, the device comprising:
- a housing configured to receive and secure a digital image detector device therein;
at least one light source configured to emit a homogeneous field of excitation light, the at least one light source being coupled to the housing and positionable to directly illuminate a target surface with the homogeneous field of excitation light, the light source being movable with respect to the housing to vary an illumination angle of the excitation light on the target surface, the target surface including at least a portion of a wound and an area around the wound;
a power supply contained in the housing and configured to provide power to the at least one light source; and
a digital image detector device configured to be removably secured in the housing and comprising;
a wireless communication device having a sensor configured to detect signals responsive to illumination of the illuminated portion of the wound and the area around the wound, each signal indicative of at least one of endogenous fluorescence, exogenous fluorescence, absorbance, and reflectance in the illuminated portion of the wound and the area around the wound, wherein the at least one light source is positionable with respect to the wireless communication device when the digital image detector device is secured in the housing;
a processor configured to receive the detected signals and to output a representation of the illuminated portion of the wound and the area around the wound based on the detected signals, wherein the processor is further configured to spatially co-register data relative to at least one of wound topography, wound anatomy, wound area, wound depth, wound volume, wound margins, and necrotic tissue, based on the detected signals, in the representation of the illuminated portion of the wound and the area around the wound; and
a display for displaying the representation of the illuminated portion of the wound and the area around the wound output by the processor.
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Accused Products
Abstract
A device for fluorescence-based imaging and monitoring of a target comprising: a light source emitting light for illuminating the target, the emitted light including at least one wavelength or wavelength band causing at least one biomarker associated with the target to fluoresce; and a light detector for detecting the fluorescence.
681 Citations
82 Claims
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1. A portable, handheld device for outputting a representation of a wound in tissue, the device comprising:
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a housing configured to receive and secure a digital image detector device therein; at least one light source configured to emit a homogeneous field of excitation light, the at least one light source being coupled to the housing and positionable to directly illuminate a target surface with the homogeneous field of excitation light, the light source being movable with respect to the housing to vary an illumination angle of the excitation light on the target surface, the target surface including at least a portion of a wound and an area around the wound; a power supply contained in the housing and configured to provide power to the at least one light source; and a digital image detector device configured to be removably secured in the housing and comprising; a wireless communication device having a sensor configured to detect signals responsive to illumination of the illuminated portion of the wound and the area around the wound, each signal indicative of at least one of endogenous fluorescence, exogenous fluorescence, absorbance, and reflectance in the illuminated portion of the wound and the area around the wound, wherein the at least one light source is positionable with respect to the wireless communication device when the digital image detector device is secured in the housing; a processor configured to receive the detected signals and to output a representation of the illuminated portion of the wound and the area around the wound based on the detected signals, wherein the processor is further configured to spatially co-register data relative to at least one of wound topography, wound anatomy, wound area, wound depth, wound volume, wound margins, and necrotic tissue, based on the detected signals, in the representation of the illuminated portion of the wound and the area around the wound; and a display for displaying the representation of the illuminated portion of the wound and the area around the wound output by the processor. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A portable, handheld device for imaging and collection of data regarding a wound in tissue, the device comprising:
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a holding frame configured to receive a wireless device; at least one light source configured to emit a homogenous field of excitation light, the at least one light source being pivotably connected to the holding frame and positionable relative to the holding frame to directly illuminate at least a portion of a wound and an area around the wound with the homogenous field of excitation light; a wireless device comprising a built-in digital camera having a lens and an image sensor configured to substantially simultaneously detect signals responsive to illumination of the portion of the wound and the area around the wound, each of the detected signals being indicative of endogenous fluorescence, exogenous fluorescence, or absorbance in the illuminated portion of the wound and the area around the wound; an optical filter holder connected to the holding frame and configured to exchangeably receive a plurality of optical filters, the optical filter holder being movable relative to the wireless device to selectively position at least one of the plurality of optical filters in front of the lens to filter one or more wavelengths of light; at least one optical filter configured to filter optical signals responsive to illumination of the portion of the wound and the area around the wound with the homogenous field of excitation light to enable optical signals having a wavelength corresponding to bacterial autofluorescence to pass through the filter to the image sensor; and a data output device configured to output a composite representation of the illuminated portion of the wound and the area around the wound in real-time, the composite representation combining at least one of spectral data and image data representative of the illuminated portion of the wound and the area around the wound based on each of the detected filtered signals, wherein the data output device is configured to identify the presence and/or location of various bacterial strains in the illuminated portion of the wound and the area around the wound in the composite representation, and wherein the data output device is further configured to differentiate between different bacterial strains present in the illuminated portion of the wound and the area around the wound based on the composite representation. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
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32. A portable, handheld device for imaging and collection of data relating to a wound in tissue, the device comprising:
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a housing comprising an enclosure configured to receive a mobile communication device; at least one light source coupled to the housing and configured to directly illuminate at least a portion of a wound and an area around the wound with a homogeneous field of light; a heat dissipating element in the housing; a power supply contained in the housing and configured to provide power to the at least one light source; a mobile communication device secured in the enclosure of the housing, the mobile communication device comprising an embedded digital camera and having a touchscreen display disposed on a first side of the device and a lens of the camera disposed on a second side of the device opposite the first side, wherein the mobile communication device is received in the housing such that an image sensor of the digital camera is positioned to detect optical signals responsive to illumination of the portion of the wound and the area around the wound with the homogeneous field of light, each of the optical signals being indicative of at least one of endogenous fluorescence, exogenous fluorescence, reflectance, and absorbance in the illuminated portion of the wound and the area around the wound, and wherein, when the mobile communication device is secured in the enclosure, at least a portion of the touchscreen display is accessible and viewable by a user; at least one spectral filtering mechanism configured to filter the optical signals emanating from the illuminated portion of the wound and the area around the wound to enable optical signals having a wavelength corresponding to bacterial autofluorescence and tissue autofluorescence to pass through the at least one spectral filtering mechanism, wherein the at least one spectral filtering mechanism is connected to the housing and is selectively movable, relative to the lens of the camera of the mobile communication device, between a first position for white light imaging and a second position for fluorescent imaging; and a processor for processing detected filtered optical signals and outputting a composite representation of the illuminated portion of the wound and the area around the wound based on the detected filtered signals in real-time as the filtered signals are detected by the sensor of the digital camera, the composite representation co-registering at least one of spectral data and image data in the detected filtered signals relative to at least one of wound topography, wound anatomy, wound area, wound depth, wound volume, wound margins, and necrotic tissue in the composite representation. - View Dependent Claims (33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44)
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45. A method of determining bacterial strain data regarding a wound in tissue with a handheld device of a wound assessment system comprising:
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supplying power to at least one light source connected to a housing of a handheld device, a power source for supplying power being contained in the housing; directly illuminating at least a portion of a wound and an area around the wound with a homogeneous field of light produced by the at least one light source of the handheld device, the at least one light source emitting at least one wavelength or wavelength band causing at least one biomarker in the illuminated portion of the wound and area around the wound to fluoresce; filtering, with at least one optical filter, optical signals emitted in response to illumination of the portion of the wound and the area around the wound with the homogenous field of excitation light, the at least one optical filter being configured to enable optical signals having a wavelength corresponding to bacterial autofluorescence to pass through the filter; detecting the filtered optical signals in real time with an image sensor of a camera of a wireless communication device, the wireless communication device being secured in the housing of the handheld device outputting a composite representation of the illuminated portion of the wound and the area around the wound, the composite representation including at least one of endogenous fluorescence data and exogenous fluorescence data based on the detected filtered signals, wherein the composite representation spatially co-registers the data relative to at least one of wound topography, wound anatomy, wound area, wound depth, wound volume, wound margins, and necrotic tissue in the illuminated portion of the wound and the area around the wound; determining the presence and/or location of bacterial strains present in the illuminated portion of the wound and area around the wound based on the detected filtered signals and/or the data in the composite representation; and differentiating between the bacterial strains when the presence and/or location of more than one bacterial strain is determined. - View Dependent Claims (46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70)
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71. A wound assessment system for assessing and monitoring a wound in tissue based on detected fluorescence-based data, reflectance data, and absorption data, the system comprising:
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a portable, handheld device for outputting a representation of a wound in tissue, comprising; a housing configured to receive a wireless communication device, the housing configured to be cleaned and/or disinfected; at least one heat dissipating device; a system for positioning the handheld device a known distance from the wound; a power source disposed in the housing and configured to power at least one light source connected to the housing, at least a portion of the at least one heat dissipating device, and the system for positioning the handheld device; the at least one light source being configured to directly illuminate and/or excite at least a portion of a wound and an area around the wound with a homogeneous field of excitation light, the at least one light source supported by and connected to the housing, the at least one light source including at least one of a light-emitting diode array and a coherent light source, wherein an intensity of the at least one light source is adjustable, the at least one light source having wavelength characteristics in at least the ultraviolet, visible, and infrared ranges, and the at least one light source configured to emit the homogenous field of excitation light capable of illuminating and/or exciting tissue and/or bacteria at and below a surface of the tissue; at least one spectral filtering mechanism configured to filter a plurality of optical signals emanating from the illuminated portion of the wound and the area around the wound in response to illumination with the homogenous field of excitation light, the first at least one spectral filtering mechanism enabling optical signals having a wavelength corresponding to bacterial autofluorescence and tissue autofluorescence to pass through the spectral filtering mechanism and preventing optical signals having a wavelength corresponding to the homogenous field of excitation light from passing through the at least one spectral filtering mechanism; a wireless communication device secured in the housing, the wireless communication device comprising a detector for detecting the filtered optical signals responsive to illumination of the portion of the wound and the area around the wound, the detected filtered optical signals being indicative of endogenous fluorescence, exogenous fluorescence, absorbance, and reflectance present in the illuminated portion of the wound and the area around the wound, the detector comprising at least one camera sensor associated with the wireless communication device; a memory for storing images and data; an optical calibrator system for calibrating characteristics of the homogenous field of excitation light emitted by the at least one light source; a processor at least partially positioned within the housing, the processor configured to process the detected filtered optical signals and to output a composite representation of the illuminated portion of the wound and the area around the wound in real time, based on the detected filtered optical signals, wherein the processor is configured to spatially and/or temporally co-register endogenous fluorescence data, exogenous fluorescence data, absorbance data, and reflectance data from the detected optical signals relative to at least one of wound topography, wound anatomy, wound area, wound depth, wound volume, wound margins, and necrotic tissue of the portion of the wound and the area around the wound in the composite representation of the illuminated portion of the wound and the area around the wound; a color and/or monochromatic touchscreen display configured to display the composite representation, the display further configured to receive user input via the touchscreen and display user input data; a user interface configured to access and manage controls for imaging parameters, image sensor activation, light source activation, acquisition of image data, actuation of filters, power, image focus, image magnification, and image stabilization, the user interface being accessible via the touchscreen display; and at least one interface for connection to an external component including at least one of a head-mounted display, a printer, a computer, an external memory device, a power source and/or power recharging source, and an endoscopic-type device; wherein the handheld device is configured to wirelessly receive and transmit images and data, and a wound analysis component comprising image analysis and/or manipulation software, configured to receive and manipulate data received from the handheld device and to output diagnostic data that includes at least one of a wound healing rate;
a biodistribution of bacteria in and around the wound;
one or more colored maps that display simultaneously the biological components of the wound and surrounding normal tissues including connective tissues, blood, microvascularity, bacteria, and microorganisms; and
visualization, in substantially real-time, of the health, healing and infectious status of the wound area, the wound analysis component running on the processor of the handheld device or on a processor associated with the wound assessment system.
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72. A method of providing diagnostic data regarding a wound in tissue with a handheld device comprising:
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directly illuminating at least a portion of a wound and an area around the wound with a homogeneous field of light emitted by at least one light source connected to a housing of a handheld device, the housing including an enclosure for receiving a wireless communication device having a digital camera, the at least one light source emitting at least one wavelength or wavelength band causing at least one biomarker in the illuminated portion of the wound and area around the wound to fluoresce; selectively positioning an optical filter holder connected to the housing of the handheld device relative to a lens of the digital camera to filter one or more wavelengths of light, the optical filter holder being configured to receive a plurality of optical filters; detecting optical signals, produced in response to the illumination of the portion of the wound and the area around the wound with the homogenous field of light, with the digital camera of the wireless communication device when the wireless communication device is secured in the housing, wherein each of the detected optical signals represents; endogenous fluorescence of the illuminated portion of the wound and the area around the wound, fluorescence of exogenously administered agents and/or materials in the illuminated portion of the wound and the area around the wound, absorbance of light by the illuminated portion of the wound and the area around the wound, or reflectance of light by the illuminated portion of the wound and the area around the wound; co-registering data, based on the detected optical signals, relative to at least one of wound topography, wound anatomy, wound area, wound depth, wound volume, wound margins, and necrotic tissue in the illuminated portion of the wound and the area around the wound; and outputting diagnostic data based on the co-registered data. - View Dependent Claims (73, 74, 75, 76, 77, 78, 79, 80, 81, 82)
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Specification