Protecting airways

• US 9,042,992 B2
• Filed: 08/30/2013
• Issued: 05/26/2015
• Est. Priority Date: 08/31/2012
• Status: Expired due to Fees

• Current Assignee: US Department of Veterans Affairs (Government of the United States of America), University of Florida Research Foundation, Incorporated (State University System of Florida)
• Original Assignee: University of Florida Research Foundation, Incorporated (State University System of Florida), The United States of America As Represented By The Secretary of Agriculture
• Inventors: Dixon, Warren E., McCoy, Sean Conrad, Bolser, Donald Clementz, Pitts, Teresa Elizabeth
• Primary Examiner(s): Koharski, Christopher D
• Assistant Examiner(s): MAHMOOD, NADIA AHMAD
• Application Number:
  US14/014,835
• Publication Number:
  US 20140067008A1
• Time in Patent Office: 634 Days
• Field of Search: 607/2, 607/48
• US Class Current: 607/48
• CPC Class Codes: A61N 1/36003 of motor muscles, e.g. for walking assistance
• CPC Class Codes: A61N 1/3601 of respiratory organs
• CPC Class Codes: A61N 1/36017 with leads or electrodes penetrating the skin
• CPC Class Codes: A61N 1/36031 using physiological parameters for adjustment
• CPC Class Codes: A61N 1/36034 specified by the stimulation parameters

Abstract

An airway of a patient is protected from intrusion of contaminants by monitoring muscles of the patient to detect an attempted cough or swallow, and applying an electrical stimulus to the neck of the patient, varying amplitude and/or frequency over time, the applied electrical stimulus operates to promote an efficacious cough or swallow. The electrical stimulus induces a voltage within a range of greater than zero volts and less than 20 volts, and the frequency have patterned changes between at least about 4 Hz to not more than about 30 Hz. The monitoring is carried out by an electronic device, and the patient may indicate to the electronic device that a swallow or cough is impending.

Claims

1. A method of protecting an airway of a patient, comprising:

monitoring muscles of the patient to detect an attempted cough or swallow;

applying an electrical stimulus to afferent nerves of at least one of the neck and head of the patient, in a pattern of varying non-zero values of at least one of pulse width, amplitude or frequency over time, the applied electrical stimulus operative to promote an efficacious cough or swallow.

2. The method of claim 1, the electrical stimulus including a voltage within a range of greater than zero volts and less than 20 volts.

3. The method of claim 1, wherein the electrical stimulus is swept through a range of between at least about 4 Hz to not more than about 30 Hz.

4. The method of claim 1, an electrical stimulus is applied before the patient has attempted to swallow, and an electrical stimulus is applied between about 1 millisecond to about 0.5 seconds after the patient has attempted to swallow or has swallowed.

5. The method of claim 1, wherein monitoring muscles is performed using EMG.

6. The method of claim 5, wherein the electrical stimulus is applied after the incidence of predetermined markers in the EMG signal.

7. The method of claim 6, wherein sensed EMG information is analyzed by one or more computer processors, the processors operative to initiate the application of the electrical stimulus.

8. The method of claim 1, wherein monitoring of muscles of the patient is carried out by an electronic device.

9. The method of claim 8, wherein the patient may indicate to the electronic device that a swallow or cough is impending.

10. A device for protecting an airway of a patient, comprising:

a plurality of electrodes positionable upon skin of the patient, the electrodes configured for capturing electromyographic information and for transmitting a stimulating electrical signal to the body;

a signal generator configured to generate a signal in a pattern of varying non-zero values of at least one of pulse width, amplitude, or frequency across at least two of the plurality of electrodes, the signal generated configured to stimulate efferent nerves of at least one of the neck and head of the patient; and

software stored on non-transitory media, executable by at least one processor, the software configured to analyze the electromyographic information to identify an attempted cough or swallow, the processor configured to cause the at least two electrodes to apply an electrical stimulus, generated from the signal generator, to the afferent nerves if the analysis indicates an attempted cough or swallow.

11. The device of claim 10, the adjusting including sweeping the signal over a range of values over time to promote an efficacious cough or swallow.

12. A method of protecting an airway of a patient, comprising:

monitoring muscles of the patient to detect an attempted cough or swallow using sensed EMG information;

analyzing information pertaining to monitoring muscles by at least one computer processor to identify an attempted cough or swallow; and

applying an electrical stimulus to at least one of the neck and head of the patient if the analysis indicates an attempted cough or swallow, the signal configured to stimulate an efferent nerve of at least one of the neck and head, and varying non-zero values of at least one of an amplitude or frequency over time, the applied electrical stimulus thereby operative to promote an efficacious cough or swallow.

13. The method of claim 12, the electrical stimulus including a voltage within a range of greater than zero volts and less than 20 volts.

14. The method of claim 12, wherein the frequency is swept through a range, the range within at least about 4 Hz to not more than about 30 Hz.

15. The method of claim 12, wherein the electrical stimulus is applied before the patient has attempted to swallow, and an electrical stimulus is applied between about 1 millisecond to about 0.5 seconds after the patient has attempted to swallow or has swallowed.

16. The method of claim 12, wherein the electrical stimulus is applied after the incidence of predetermined markers in the EMG signal.

17. The method of claim 12, wherein sensed EMG information is analyzed by one or more computer processors, the processors operative to initiate the application of the electrical stimulus.

18. The method of claim 12, wherein monitoring of muscles of the patient is carried out by an electronic device.

19. The method of claim 18, wherein the patient may indicate to the electronic device that a swallow or cough is impending.

20. The method of claim 12, wherein varying non-zero values includes changing the stimulation for a patient to decrease a possibility of habituation to the stimulus by the patient.

21. The method of claim 12, wherein the signal is applied for periods longer than 20 seconds, to bring about synaptic plasticity within the patient.