Electrochemical sensor and method for manufacturing

• US 9,044,178 B2
• Filed: 08/28/2008
• Issued: 06/02/2015
• Est. Priority Date: 08/30/2007
• Status: Active Grant

• Current Assignee: Pepex Biomedical, Inc.
• Original Assignee: Pepex Biomedical, LLC
• Inventors: Say, James L.
• Primary Examiner(s): Ball, J. Christopher
• Assistant Examiner(s): Kessel, Maris R
• Application Number:
  US12/674,876
• Publication Number:
  US 20110203941A1
• Time in Patent Office: 2,469 Days
• Field of Search: 20440301-40315, 205/777.5, 205/778, 205/792, 600345-348
• US Class Current: 1/1
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: G01N 27/3272 Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels optical biosensors G01N33/52

Abstract

A sensor includes a sheath that is elongated along a longitudinal axis; a spacer positioned within the sheath and defining first and second channels having lengths that extend along the longitudinal axis; a first elongated member positioned within the first channel; and a second elongated member positioned within the second channel. The first elongated member includes an active surface forming a working electrode and the second elongated member including an active surface defining a counter electrode.

Claims

1. A sensor for sensing an analyte in a sample comprising:

an outer member that is elongated along a longitudinal axis;

a spacer positioned within the outer member, the spacer defining first and second channels having lengths that extend along the longitudinal axis, the channels further having open longitudinal sides facing outwardly toward the outer member;

a first elongated member positioned within the first channel, the first elongated member defining a working electrode having a sensing layer; and

a second elongated member positioned within the second channel, the second elongated member defining a counter electrode, a reference electrode, or a combined reference and counter electrode;

the spacer being sized and configured to separate the first elongated member from the second elongated member and to provide open space extending along the longitudinal axis between the outer member and the first and second elongated members through which a test sample can flow, the sensing layer having an axial length that extends along a corresponding axial length of the spacer so that the sensing layer is accessible within the open space, thereby enabling the sensing layer to be wetted along its axial length by the test sample as the test sample moves longitudinally through the open space.

2. The sensor of claim 1, wherein the second elongated member defines a counter electrode;

and wherein the spacer further defines a third channel in which a third elongated member is positioned, the third elongated member defining a reference electrode.

3. The sensor of claim 1, wherein active surfaces of the elongated members project outwardly from the outer member and face radially outwardly from the channels of the spacer.

4. The sensor of claim 3, wherein the outer member extends around the active surfaces and defines an open end to facilitate access to the active surfaces.

5. The sensor of claim 1, wherein the spacer is constructed of a dielectric material.

6. The sensor of claim 1, wherein the first elongated member includes a dielectric core surrounded by a conductive layer, which is covered by the sensing layer.

7. The sensor of claim 1, wherein each elongated member includes a composite nylon monofilament conductive thread material.

8. The sensor of claim 1, wherein the outer member includes an insulating sheath.

9. A sensor for sensing an analyte in a sample comprising:

an outer member that is elongated along a longitudinal axis;

a spacer positioned within the outer member, the spacer defining a channel having a length that extends along the longitudinal axis, the channel further having an open longitudinal side facing outwardly toward the outer member;

a first elongated member positioned within the channel, the first elongated member defining a working electrode having a sensing layer;

the spacer being sized and configured to provide open spacing extending along the longitudinal axis between the outer member and the sensing layer of the working electrode through which a test sample can flow, the sensing layer having an axial length that extends along a corresponding axial length of the spacer, and the sensing layer being wetted along its axial length by the test sample as the test sample moves longitudinally through the open spacing.

10. The sensor of claim 9, wherein an active surface of the first elongated member projects outwardly from the outer member and faces radially outwardly from the channel of the spacer.

11. The sensor of claim 10, wherein the outer member extends around the active surface and defines an open end to facilitate access to the active surface.

12. The sensor of claim 9, wherein the spacer is constructed of a dielectric material.

13. The sensor of claim 9, wherein the first elongated member includes a dielectric core surrounded by a conductive layer, which is covered by the sensing layer.

14. The sensor of claim 9, wherein the first elongated member includes a composite nylon monofilament conductive thread material.

15. The sensor of claim 9, wherein the outer member includes an insulating sheath.