Method and apparatus for treatment of intracranial hemorrhages
First Claim
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1. A method for treating an extravascular blood clot in a patient resulting from an intracranial hemorrhage comprising:
- forming a hole in the patient'"'"'s skullextravascularly positioning at least a portion of a treatment region of an elongate tubular body of an ultrasound catheter into the extravascular blood clot by advancing the device through an opening provided in a skull of the patient;
wherein the elongate tubular body further has a distal portion and a proximal portion, and wherein the ultrasound catheter further comprises;
a plurality of ultrasound radiating members positioned within the treatment region of the elongate tubular body, the treatment region being positioned within the distal portion of the elongate tubular body;
a first fluid delivery lumen formed within the elongate tubular body, wherein the first fluid delivery lumen extends from the proximal portion of the elongate tubular body to the treatment region and includes a first fluid delivery port located on a first axial region of the treatment region of the elongate tubular body, the first fluid delivery port extending from an exterior surface of the elongate tubular body and configured to allow a fluid to flow from within the first fluid delivery lumen to a portion of the blood clot positioned outside the elongate tubular body;
a first fluid evacuation lumen formed within the elongate tubular body, wherein the first fluid evacuation lumen extends from the proximal portion of the elongate tubular body to the treatment region and includes a first fluid evacuation port located on a second axial region of the treatment region of the elongate tubular body, the first fluid evacuation lumen extending from an exterior surface of the elongate tubular body and configured to allow a fluid to flow into the first fluid evacuation lumen from a position outside the elongate tubular body, the first and second axial regions being positioned at distinct longitudinal positions on the elongate body, and;
wherein at least one of the plurality of ultrasound radiating members are located axially between the first fluid delivery port and the first fluid evacuation port;
activating the ultrasound assembly;
delivering a lytic drug to the blood clot through the first fluid delivery lumen; and
evacuating a at least a portion of the extravascular blood clot around the distal portion of the elongate tubular body into the first fluid evacuation lumen.
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Abstract
An ultrasound catheter with fluid delivery lumens, fluid evacuation lumens and a light source is used for the treatment of intracerebral hemorrhages. After the catheter is inserted into a blood clot in the brain, a lytic drug can be delivered to the blood clot via the fluid delivery lumens while applying ultrasonic energy to the treatment site. As the blood clot is dissolved, the liquefied blood clot can be removed by evacuation through the fluid evacuation lumens.
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Citations
11 Claims
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1. A method for treating an extravascular blood clot in a patient resulting from an intracranial hemorrhage comprising:
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forming a hole in the patient'"'"'s skull extravascularly positioning at least a portion of a treatment region of an elongate tubular body of an ultrasound catheter into the extravascular blood clot by advancing the device through an opening provided in a skull of the patient;
wherein the elongate tubular body further has a distal portion and a proximal portion, and wherein the ultrasound catheter further comprises;a plurality of ultrasound radiating members positioned within the treatment region of the elongate tubular body, the treatment region being positioned within the distal portion of the elongate tubular body; a first fluid delivery lumen formed within the elongate tubular body, wherein the first fluid delivery lumen extends from the proximal portion of the elongate tubular body to the treatment region and includes a first fluid delivery port located on a first axial region of the treatment region of the elongate tubular body, the first fluid delivery port extending from an exterior surface of the elongate tubular body and configured to allow a fluid to flow from within the first fluid delivery lumen to a portion of the blood clot positioned outside the elongate tubular body; a first fluid evacuation lumen formed within the elongate tubular body, wherein the first fluid evacuation lumen extends from the proximal portion of the elongate tubular body to the treatment region and includes a first fluid evacuation port located on a second axial region of the treatment region of the elongate tubular body, the first fluid evacuation lumen extending from an exterior surface of the elongate tubular body and configured to allow a fluid to flow into the first fluid evacuation lumen from a position outside the elongate tubular body, the first and second axial regions being positioned at distinct longitudinal positions on the elongate body, and; wherein at least one of the plurality of ultrasound radiating members are located axially between the first fluid delivery port and the first fluid evacuation port; activating the ultrasound assembly; delivering a lytic drug to the blood clot through the first fluid delivery lumen; and evacuating a at least a portion of the extravascular blood clot around the distal portion of the elongate tubular body into the first fluid evacuation lumen. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A method for treating an extravascular blood clot positioned outside a blood vessel in a patient resulting from an intracranial hemorrhage in the patient, the method comprising:
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forming a hole in the patient'"'"'s skull; advancing a catheter assembly through the hole, the catheter assembly having a distal portion and a proximal portion, the catheter assembly comprising at least one ultrasound radiating member located in the distal portion, a first fluid delivery lumen extending from the proximal portion to the distal portion and a first fluid evacuation lumen extending from the proximal portion to the distal portion, wherein the first fluid delivery lumen includes a first fluid delivery port located on the distal portion of the catheter assembly and configured to allow a fluid to flow from within the first fluid delivery lumen to the extravascular blood clot positioned outside the catheter assembly, and wherein the first fluid evacuation lumen includes a first fluid evacuation port located the distal portion of the catheter assembly and configured to allow a fluid to flow into the first fluid evacuation lumen from outside the catheter assembly; extravascularly positioning at least a portion of the distal portion of the catheter assembly comprising the at least one ultrasound radiating member, the first fluid delivery lumen and the first fluid evacuation lumen into the extravascular blood clot formed by the intracranial hemorrhage and positioned outside a blood vessel; activating the ultrasound radiating member; monitoring the intracranial pressure of the patient; delivering a first fluid through the first fluid delivery lumen and the first fluid delivery port to the blood clot; and evacuating a second fluid through the first evacuation lumen and the first evacuation port. - View Dependent Claims (9, 10, 11)
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Specification