Method and system for validating local capture in multisite pacing delivery

• US 9,044,615 B2
• Filed: 08/15/2013
• Issued: 06/02/2015
• Est. Priority Date: 08/15/2013
• Status: Active Grant

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Inventors: Hou, Wenbo, Rosenberg, Stuart, Min, Xiaoyi, Keel, Allen
• Primary Examiner(s): Stice, Paula J
• Application Number:
  US13/968,233
• Publication Number:
  US 20150051661A1
• Time in Patent Office: 656 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61B 5/35 by template matching
• CPC Class Codes: A61N 1/3712 Auto-capture, i.e. automatic adjustment of the stimulation threshold

Abstract

A method for use with an implantable system including a lead having multiple electrodes implantable proximate to a patient'"'"'s left ventricular (LV) chamber includes simultaneously delivering pacing pulses over corresponding pacing vectors defined by electrodes proximate to the LV chamber. The method includes recording evoked responses responsive to the pacing pulses that are measured over separate corresponding sensing channels. The method also includes comparing the evoked responses to a template that represents local capture of a local LV tissue region along one or more of the corresponding pacing vectors. The comparison is used to determine whether the pacing pulses achieved local capture along the corresponding pacing vectors. At least one of the pacing pulses or pacing vectors are updated based on the comparison of the evoked responses to the template in order to determine a local capture threshold for the corresponding pacing vectors.

Claims

1. An implantable cardiac stimulation (ICS) system including a lead having multiple electrodes implantable proximate to a patient'"'"'s left ventricular (LV) chamber, the system comprising:

a pacing pulse delivery (PPD) module configured to simultaneously deliver multiple pacing pulses over corresponding left ventricular pacing vectors, the pacing vectors defined by electrodes proximate to the LV chamber;

an evoked response recording (ERR) module configured to record evoked responses that are responsive to the pacing pulses, the evoked responses associated with the corresponding pacing pulses and measured over separate corresponding sensing channels;

an evoked response comparison (ERC) module configured to compare the evoked responses to at least one template, the at least one template representing local capture of a local LV tissue region along one or more of the corresponding pacing vectors, the comparison used to determine whether the pacing pulses achieved local capture along the corresponding pacing vectors; and

a pacing pulse update (PPU) module configured to update at least one of the pacing pulses or the pacing vectors based on the comparison of the evoked responses to the at least one template in order to determine a local capture threshold for the corresponding pacing vectors.

2. The ICS system of claim 1, wherein the at least one template is representative of an evoked response responsive to a pacing pulse that is determined by a clinician to achieve local capture.

3. The ICS system of claim 1, wherein the ERC module is configured to compare the evoked responses to a single template that represents local capture.

4. The ICS system of claim 1, wherein the ERC module is configured to compare the evoked responses to different templates, the different templates representative of local capture along the respective pacing vectors.

5. The ICS system of claim 1, wherein the ERC module is configured to perform a waveform correlation between the evoked responses and the at least one template.

6. The ICS system of claim 1, wherein the ERC module is configured to compare at least one of an area under a curve, a maximum amplitude of a curve, or a maximum slope of a curve within a waveform represented in an intracardiac electrogram.

7. The ICS system of claim 1, wherein the PPU module is configured to increase a pacing output of a next pacing pulse over one pacing vector if the pacing pulse did not achieve local capture along the pacing vector, or to decrease the pacing output of the next pacing pulse over the pacing vector if the pacing pulse achieved local capture along the pacing vector.

8. The ICS system of claim 1, wherein the PPD module is configured to simultaneously deliver the pacing pulses over the corresponding pacing vectors for multiple cardiac cycles until the local capture threshold for each of the pacing vectors is determined.