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Anti-DLL4/VEGF dual variable domain immunoglobulin and uses thereof

  • US 9,045,551 B2
  • Filed: 06/11/2014
  • Issued: 06/02/2015
  • Est. Priority Date: 11/01/2012
  • Status: Active Grant
First Claim
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1. A binding protein comprising first and second polypeptide chains, each independently comprising VD1-(X1)n-VD2-C-(X2)n, whereinVD1 is a first variable domain;

  • VD2 is a second variable domain;

    C is a constant domain;

    X1 is a linker;

    X2 is an Fc region;

    n is 0 or 1,wherein the VD1 domains on the first and second polypeptide chains form a first functional target binding site and the VD2 domains on the first and second polypeptide chains form a second functional target binding site, and wherein the binding protein is capable of binding DLL4 and VEGF, wherein the first polypeptide chain of the binding protein comprises SEQ ID NO;

    56 and the second polypeptide chain of the binding protein comprises SEQ ID NO;

    64.

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