Method and apparatus for detection and treatment of respiratory disorder by implantable device

• US 9,050,024 B2
• Filed: 02/25/2010
• Issued: 06/09/2015
• Est. Priority Date: 02/20/2004
• Status: Active Grant

• Current Assignee: ResMed Pty Ltd. (ResMed Incorporated)
• Original Assignee: Redmed Limited
• Inventors: Ujhazy, Anthony John, Brewer, Gregory Newton
• Primary Examiner(s): Stice, Paula J
• Application Number:
  US12/712,856
• Publication Number:
  US 20100152553A1
• Time in Patent Office: 1,930 Days
• Field of Search: 607/42, 600529-543
• US Class Current: 1/1
• CPC Class Codes: A61B 5/0538 invasively, e.g. using a catheter
• CPC Class Codes: A61B 5/0809 by impedance pneumography
• CPC Class Codes: A61B 5/4047 afferent nerves, i.e. nerves that relay impulses to the central nervous system
• CPC Class Codes: A61B 5/4818 Sleep apnoea
• CPC Class Codes: A61N 1/3601 of respiratory organs

Abstract

Methods and apparatus for detection and treatment of respiratory disorders using implanted devices are described. In one form, afferent nerves are electrically or electro-mechanically stimulated to increase the tone of upper airway muscles. Detection of respiratory disorders is carried out using electrodes implanted in sub-pectoral regions. Open and closed airway apneas are distinguished using a combination of acoustic detectors and electrical transducers.

Claims

1. A method for identifying a respiratory disorder in a patient using a device implanted in the patient, comprising:

sensing patient sounds,

analyzing frequency and amplitude of the patient sounds to determine airflow,

measuring said patient'"'"'s transthoracic impedance to determine thoracic movement, and

identifying the respiratory disorder to distinguish central apnea and obstructive apnea based upon the determined airflow and determined thoracic movement;

said device implanted in the patient including a microphone to sense patient sounds, a processor to analyze the frequency and amplitude of the sensed patient sounds to determine airflow, and an impedance detector to detect transthoracic impedance by

     1) emitting high frequency electrical pulses to traverse the transthoracic cavity, and

     2) calculating instantaneous transthoracic impedance across said transthoracic cavity.

2. The method of claim 1 wherein the impedance detector is configured to detect transthoracic impedance change by comparing said instantaneous transthoracic impedance to a recent average of instantaneous transthoracic impedances.

3. The method of claim 1 wherein said microphone further senses signals indicative of patient snoring which are used to determine the potential onset of sleep disordered breathing.

4. The method of claim 1 wherein the processor determines a potential onset of the respiratory disorder based on the patient sounds.

5. The method of claim 1 wherein transthoracic impedance is calculated by measuring current and voltage and by using Ohm'"'"'s Law.

6. The method of claim 1 wherein said high frequency electrical pulses are at any energy level below the level required to stimulate excitable tissue.

7. The method of claim 1, wherein the processor determines occurrence of central apnea when there is no airflow and no thoracic movement.

8. The method of claim 1, wherein the processor determines occurrence of obstructive apnea when the thoracic movement is detected without corresponding airflow.

9. An implantable apparatus for determining the presence of sleep disordered breathing in a patient, comprising:

an impedance detector configured to detect transthoracic impedance by

     1) emitting high frequency electrical pulses to traverse the transthoracic cavity, and

     2) calculating instantaneous transthoracic impedance across said transthoracic cavity,

a microphone configured to capture signals representing patient sounds, and

a processor configured to determine the presence of sleep disordered breathing;

wherein said processor determines the presence of sleep disordered breathing by analyzing said patient-sound signals for frequency and amplitude to determine airflow, measuring said patient'"'"'s transthoracic impedance to determine thoracic movement, determining the sleep disordered breathing to distinguish central apnea and obstructive apnea based upon the determined airflow and the patient'"'"'s determined thoracic movement.

10. The apparatus of claim 9 wherein the impedance detector is configured to detect transthoracic impedance change by comparing said instantaneous transthoracic impedance to a recent average of instantaneous transthoracic impedances.

11. The apparatus of claim 9 wherein said microphone captures signals indicative of patient snoring which are used by said processor to identify the presence of sleep disordered breathing.

12. The apparatus of claim 9 wherein the processor determines thoracic movement by measuring electrical impedance between at least two electrodes.

13. The apparatus of claim 9 wherein transthoracic impedance is calculated by measuring current and voltage and by using Ohm'"'"'s Law.

14. The apparatus of claim 9 wherein said high frequency electrical pulses are at an energy level below the level required to stimulate excitable tissue.

15. The apparatus of claim 9, wherein the processor determines occurrence of central apnea when there is no airflow and no thoracic movement.

16. The apparatus of claim 9, wherein the processor determines occurrence of obstructive apnea when the thoracic movement is detected without corresponding airflow.

17. A method for identifying a respiratory disorder in a patient using a device coupled to the patient, comprising:

receiving signals associated with patient sounds,

analyzing frequency and amplitude of the signals to determine airflow,

measuring said patient'"'"'s transthoracic impedance to determine thoracic movement, and

determining the respiratory disorder to distinguish central apnea and obstructive apnea based upon the determined airflow and the determined thoracic movement;

said device coupled to the patient including a microphone for receiving signals representative of patient sounds, a processor to determine airflow based on the frequency and amplitude of patient sounds, and an impedance detector to detect transthoracic impedance by

     1) emitting high frequency electrical pulses to traverse the transthoracic cavity and

     2) calculating instantaneous transthoracic impedance across said transthoracic cavity.

18. The method of claim 17 wherein the impedance detector is configured to detect transthoracic impedance change by comparing said instantaneous transthoracic impedance to a recent average of instantaneous transthoracic impedances.

19. The method of claim 17 wherein said microphone further receives signals indicative of patient snoring which are used to determine the potential onset of sleep disordered breathing.

20. The method of claim 17, wherein the processor determines the thoracic movement by measuring electrical impedance between at least two electrodes.

21. The method of claim 17 wherein the transthoracic impedance is calculated by measuring current and voltage and by using Ohm'"'"'s Law.

22. The method of claim 17 wherein said high frequency electrical pulses are at an energy level below the level required to stimulate excitable tissue.

23. The method of claim 17, wherein the processor determines occurrence of central apnea when there is no airflow and no thoracic movement.

24. The method of claim 17, wherein the processor determines occurrence of obstructive apnea when the thoracic movement is detected without corresponding airflow.

25. An apparatus for determining sleep disordered breathing in a patient comprising:

an impedance detector configured to detect transthoracic impedance by

     1) emitting high frequency electrical pulses to traverse the transthoracic cavity, and

     2) calculating instantaneous transthoracic impedance across said transthoracic cavity,

a microphone configured to receive signals representing patient sounds, and

a processor configured to process said signals to determine airflow based on frequency and amplitude of the patient sounds, the processor being configured to determine thoracic movement based on the transthoracic impedance;

wherein said device is configured to determine the sleep disordered breathing to distinguish central apnea and obstructive apnea based upon the patient'"'"'s determined thoracic movement and the determined airflow.

26. The apparatus of claim 25 wherein the impedance detector is configured to detect transthoracic impedance change by comparing said instantaneous transthoracic impedance to a recent average of instantaneous transthoracic impedances.

27. The apparatus of claim 25 wherein said microphone receives signals indicative of patient snoring which are used by said processor to identify the presence of sleep disordered breathing.

28. The apparatus of claim 25 wherein the processor determines the thoracic movement by measuring electrical impedance between at least two electrodes.

29. The apparatus of claim 25 wherein the transthoracic impedance is calculated by measuring current and voltage and by using Ohm'"'"'s Law.

30. The apparatus of claim 25 wherein said high frequency electrical pulses are at an energy level below the level required to stimulate excitable tissue.

31. The apparatus of claim 25, wherein the processor determines occurrence of central apnea when there is no airflow and no thoracic movement.

32. The apparatus of claim 25, wherein the processor determines occurrence of obstructive apnea when the thoracic movement is detected without corresponding airflow.