Compositions and methods for surface abrasion with frozen particles

• US 9,050,070 B2
• Filed: 02/26/2009
• Issued: 06/09/2015
• Est. Priority Date: 10/31/2008
• Status: Expired due to Fees

• Current Assignee: Gearbox LLC (Intellectual Ventures LLC)
• Original Assignee: The Invention Science Fund I, L.L.C. (Intellectual Ventures LLC)
• Inventors: Boyden, Edward S., Cook, Daniel B., Hyde, Roderick A., Leuthardt, Eric C., Myhrvold, Nathan P., Sweeney, Elizabeth A., Wood, Lowell L. Jr.
• Primary Examiner(s): Hartley, Michael G
• Assistant Examiner(s): Rider, Lance W
• Application Number:
  US12/380,552
• Publication Number:
  US 20100111832A1
• Time in Patent Office: 2,294 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61B 17/545 using a stream or spray of abrasive particles
• CPC Class Codes: A61B 18/02 by cooling, e.g. cryogenic techniques devices for cooling specific reflex points of the body within cell-life limits A61H39/06
• CPC Class Codes: A61K 31/00 Medicinal preparations containing organic active ingredients
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: A61K 51/12 characterised by a special physical form, e.g. emulsion, microcapsules, liposomes , characterized by a special physical form, e.g. emulsions, dispersions, microcapsules liposomes A61K51/1234
• CPC Class Codes: A61K 9/00 Medicinal preparations characterised by special physical form nuclear magnetic resonance contrast preparations or magnetic resonance imaging contrast preparations A61K49/18; preparations containing radioactive substances A61K51/12
• CPC Class Codes: A61K 9/08 Solutions composition of solutions A61K47/00
• CPC Class Codes: A61K 9/16 Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction A61K9/20 takes precedence if the final form is a tablet; microspheres with drug-free outer coating, microcapsules A61K9/50; mixture of different granules, microcapsules, (coated) microparticles A61K9/5084; nanoparticles A61K9/51

Abstract

Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.

Claims

1. A method for abrasion of at least one biological tissue surface of a subject, comprising:

delivering at least one composition to at least one surface of at least one biological tissue of a subject in a manner sufficient to abrade the at least one surface of the at least one biological tissue;

wherein the at least one composition includes one or more frozen hydrogen oxide particles coated with at least one of fibrin, thrombin, or fibrinogen,

wherein the one or more frozen hydrogen oxide particles have at least one major dimension of approximately one micrometer or less.

2. The method of claim 1, wherein the at least one composition includes one or more reinforcement agents including poly-lactic acid, aromatic polyamide, modacrlyic, olefin, polyester, acrylic, vinylidene chloride, vectran, polypyridobenzimidazole, saran, spanadex, vinalon, modal polybenzimidazole, sulfur, lyocel, orlon, zylon, ceramic, fiberglass, vinylester matrix, metal, or vinyon.

3. The method of claim 1, wherein the at least one composition includes one or more explosive materials including acetone peroxide, trinitrotoluene, nitrocellulose, carbon monoxide, chlorine, potassium nitrate, potassium chlorate, potassium nitrate, ammonium nitrate, or phosphorous.

4. The method of claim 1, wherein delivering at least one composition to at least one biological tissue includes propelling the composition toward the at least one biological tissue.

5. The method of claim 4, wherein the at least one composition is propelled to a predetermined velocity for delivery of the at least one composition to a desired location of the at least one biological tissue.

6. The method of claim 1, wherein delivering at least one composition includes ejecting the composition toward at least one biological tissue.

7. The method of claim 1, wherein delivering at least one composition includes accelerating the composition toward at least one biological tissue.

8. The method of claim 7, wherein the at least one composition is accelerated to a predetermined velocity for delivery of the at least one composition to a desired location of the at least one biological tissue.

9. The method of claim 1, wherein the delivering at least one composition to at least one biological tissue includes propelling, ejecting, or accelerating multiple frozen particles toward the at least one biological tissue.

10. The method of claim 1, further including extracting or collecting material from the at least one abraded surface of at least one biological tissue.

11. The method of claim 10, further including extracting or collecting one or more cells from the at least one abraded surface of at least one biological tissue.

12. The method of claim 1, wherein the at least one biological tissue is located in at least one of in situ, in vitro, in vivo, in utero, in planta, or ex vivo.

13. The method of claim 12, wherein the at least one biological tissue is located in at least one tissue or organ related to transplantation.

14. The method of claim 13, wherein the at least one tissue or organ related to transplantation includes at least one donor or recipient tissue or organ.

15. The method of claim 14, wherein the at least one donor includes at least one cadaver.

16. The method of claim 12, wherein the at least one biological tissue is ingested by at least one subject.

17. The method of claim 1, wherein the at least one biological tissue includes at least one cell mass.

18. The method of claim 1, further including delivering to the at least one biological tissue at least one of a polymer, biopolymer, nanoparticle, or detection material.

19. The method of claim 18, wherein the detection material includes at least one electronic identification device.

20. The method of claim 19, wherein the at least one electronic identification device includes at least one radio frequency identification device.

21. The method of claim 18, wherein the detection material includes at least one radioactive element.

22. The method of claim 18, wherein the detection material includes at least one colorimetric substance.

23. The method of claim 22, wherein the at least one colorimetric substance includes one or more of a dye, pigment, or light-emitting substance.

24. The method of claim 23, wherein the light-emitting substance includes at least one of a fluorescent substance, phosphorescent substance, or quantum dot.

25. The method of claim 18, wherein the detection material includes at least one of a diamagnetic particle, ferromagnetic particle, paramagnetic particle, super paramagnetic contrast agent, or other magnetic particle.

26. The method of claim 1, wherein the subject includes at least one invertebrate or vertebrate animal.

27. The method of claim 26, wherein the subject includes at least one human.

28. The method of claim 1, wherein the at least one composition further includes one or more explosive materials.

31. The method of claim 1, wherein the device is located in a wall, overhead apparatus, corral, or gate.

29. A method for abrasion of at least one biological tissue surface of a subject, comprising:

delivering at least one frozen composition to at least one surface of at least one biological tissue of a subject at a predetermined pressure or velocity, by way of a remotely controlled device built in a wall, overhead apparatus, corral, or gate, and in a manner sufficient to abrade the at least one surface of the at least one biological tissue;

wherein the at least one composition includes one or more frozen carbon dioxide particles coated with at least one of fibrin, thrombin, or fibrinogen,

wherein the one or more frozen carbon dioxide particles have at least one major dimension of approximately one micrometer or less.

30. The method of claim 29, wherein the predetermined pressure or velocity is determined by a computer program and considering at least one of size and density of the particle, content of the particle, density of the biological tissue, or type of biological tissue.