Methods and devices for passive residual lung volume reduction and functional lung volume expansion

• US 9,050,094 B2
• Filed: 03/19/2009
• Issued: 06/09/2015
• Est. Priority Date: 03/12/2007
• Status: Active Grant

• Current Assignee: Pulmonx Corp.
• Original Assignee: Pulmonx Corp.
• Inventors: Aljuri, Nikolai, Perkins, Rodney C., Olivera, Ryan, Nguyen, Hoang, Radhakrishnan, Sri, Beyhan, Niyazi
• Primary Examiner(s): Anderson, Lynne
• Assistant Examiner(s): PHILIPS, BRADLEY H
• Application Number:
  US12/407,709
• Publication Number:
  US 20090241964A1
• Time in Patent Office: 2,273 Days
• Field of Search: 128/204.14, 128/204.15, 128/204.17, 600/115, 600/116
• US Class Current: 1/1
• CPC Class Codes: A61B 1/2676 Bronchoscopes
• CPC Class Codes: A61B 17/12104 in an air passage
• CPC Class Codes: A61B 17/12136 Balloons
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61B 5/08 Detecting, measuring or recording devices for evaluating the respiratory organs A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/4836 Diagnosis combined with treatment in closed-loop systems or methods A61B5/0036 takes precedence
• CPC Class Codes: A61F 2002/043 Bronchi
• CPC Class Codes: A61M 16/0003 Accessories therefor, e.g. sensors, vibrators, negative pressure
• CPC Class Codes: A61M 16/0434 Cuffs
• CPC Class Codes: A61M 16/0436 Special fillings therefor
• CPC Class Codes: A61M 16/208 Non-controlled one-way valves, e.g. exhalation, check, pop-off non-rebreathing valves
• CPC Class Codes: A61M 2016/0027 pressure meter
• CPC Class Codes: A61M 2016/003 with a flowmeter
• CPC Class Codes: A61M 2025/1052 for temporarily occluding a vessel for isolating a sector
• CPC Class Codes: A61M 2202/0208 Oxygen
• CPC Class Codes: A61M 2205/3334 Measuring or controlling the flow rate
• CPC Class Codes: A61M 2207/10 Device therefor
• CPC Class Codes: A61M 25/10 Balloon catheters A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02; inflatable balloons for placing stents or stent-grafts A61F2/958 ; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00
• CPC Class Codes: Y10T 29/49826 Assembling or joining

Abstract

The volume of a hyperinflated lung compartment is reduced by sealing a distal end of the catheter in an airway feeding the lung compartment. Air passes out of the lung compartment through a passage in the catheter while the patient exhales. A one-way flow element associated with the catheter prevents air from re-entering the lung compartment as the patient inhales. Over time, the pressure of regions surrounding the lung compartment cause it to collapse as the volume of air diminishes. Residual volume reduction effectively results in functional lung volume expansion. Optionally, the lung compartment may be sealed in order to permanently prevent air from re-entering the lung compartment. The invention further discloses a catheter with a transparent occlusion element at its tip that enables examination of the lung passageway through a viewing scope.

Claims

1. A catheter for isolating and deflating a hyperinflated lung compartment, said catheter comprising:

a catheter body having a distal end, a proximal end, and at least one lumen extending from the distal end to the proximal end, wherein at least a distal portion of the catheter body is adapted to be advanced through the airways of the lung;

a transparent expandable occluding member disposed near a distal end of the catheter body, wherein said occluding member is adapted to be expanded in an airway which feeds the hyperinflated lung compartment such that access to the compartment is provided only through the lumen when the occluding member is expanded, and wherein the shape and material of the transparent occluding member are configured such that the transparent occluding member forms a wide angle lens, wherein the wide angle lens is formed by attaching a proximal end of the transparent occluding member circumferentially to an outer surface of the catheter body and attaching a distal portion of the transparent occluding member circumferentially to an inner surface of the lumen; and

a one-way flow element adapted to be disposed within or in-line with the lumen so that flow in a distal-to-proximal direction is allowed and flow in a proximal-to-distal direction is inhibited or prevented.

2. A catheter as in claim 1, wherein the occluding member is expandable to sealingly engage the walls of the airway.

3. A catheter as in claim 1, wherein the occluding member is an elastomeric balloon.

4. A catheter as in claim 1, wherein the catheter body has a length in the range from 20 cm to 200 cm and a diameter near the distal end in the range from 0.1 mm to 10 mm.

5. A catheter as in claim 1, wherein the expandable occluding member is an inflatable balloon, cuff, or braided balloon.

6. A catheter as in claim 1, wherein the expandable occluding member has a width in the range from 1 mm to 30 mm when fully expanded.

7. A catheter as in claim 1, wherein the one-way flow element is disposed in the lumen.

8. A catheter as in claim 7, wherein the one-way flow element is disposed in the lumen near the distal end of the catheter body.

9. A catheter as in claim 1, further comprising a hub disposed on the proximal end of the catheter body.

10. A catheter as in claim 9, wherein the one-way flow element is disposed in the hub.

11. A catheter as in claim 10, wherein the hub is removable and can be attached in-line with the lumen.

12. A catheter as in claim 1, wherein the expandable member is configured to focus or diffuse a therapeutic electromagnetic energy delivered to the airway or the lung compartment.

13. A catheter for isolating and deflating a hyperinflated lung compartment, said catheter comprising:

a catheter body having a distal end, a proximal end, and at least one lumen extending from the distal end to the proximal end, wherein at least a distal portion of the catheter body is adapted to be advanced through the airways of the lung; and

a transparent expandable occluding member disposed near a distal end of the catheter body, wherein said occluding member is adapted to be expanded in an airway which feeds the hyperinflated lung compartment such that access to the compartment is provided only through the lumen when the occluding member is expanded, and wherein the shape and material of the transparent occluding member are configured such that the transparent occluding member forms a wide angle lens, wherein the wide angle lens is formed by attaching a proximal end of the transparent occluding member circumferentially to an outer surface of the catheter body and attaching a distal portion of the transparent occluding member circumferentially to an inner surface of the lumen;

wherein the catheter is configured to connect to a console comprising a one-way flow control assembly in-line with the lumen so that flow in a distal-to-proximal direction is allowed and flow in a proximal-to-distal direction is inhibited or prevented.

14. A catheter as in claim 13, wherein the occluding member is expandable to sealingly engage the walls of the airway.

15. A catheter as in claim 13, wherein the occluding member is an elastomeric balloon.

16. A catheter as in claim 13, wherein the expandable member is configured to focus or diffuse a therapeutic electromagnetic energy delivered to the airway or the lung compartment.