Medical devices and methods for modulation of physiology using device-based surface chemistry
First Claim
1. An implantable medical device, comprising:
- a body having a surface adapted to be placed adjacent to a biological tissue or fluid in vivo;
at least one moiety attached to the surface, wherein the moiety is capable of catalyzing a first reaction upon contacting a first substrate in the biological tissue or fluid; and
wherein the at least one moiety remains attached to the surface after the first reaction and is capable of catalyzing at least a second reaction upon contacting a second substrate.
0 Assignments
0 Petitions
Accused Products
Abstract
This invention provides implantable medical devices having at least one moiety attached to the surface capable of catalyzing a reaction in vivo. The implantable medical device has a body such as a stent with a surface adapted to be placed adjacent to a biological tissue or fluid. The body has at least one moiety attached to the surface which is capable of catalyzing a first reaction upon contacting a first substrate in the biological tissue or fluid. The moiety remains attached to the surface after the first reaction and is capable of catalyzing at least a second reaction upon contacting a second substrate. In preferred embodiments the moiety is capable of catalyzing a multitude of reactions as substrates come into contact and then leave the surface of the device.
-
Citations
53 Claims
-
1. An implantable medical device, comprising:
-
a body having a surface adapted to be placed adjacent to a biological tissue or fluid in vivo; at least one moiety attached to the surface, wherein the moiety is capable of catalyzing a first reaction upon contacting a first substrate in the biological tissue or fluid; and wherein the at least one moiety remains attached to the surface after the first reaction and is capable of catalyzing at least a second reaction upon contacting a second substrate. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51)
-
-
52. A method of making an implantable medical device, comprising:
-
providing a body having a surface adapted for placement adjacent to a biological tissue or fluid in vivo; and attaching at least one chemical moiety to the surface, wherein the moiety is capable of catalyzing a first reaction upon contacting a first substrate in the biological tissue or fluid and remaining attached to the surface after the first reaction, and is capable of catalyzing at least a second reaction upon contact with a second substrate.
-
-
53. A method for catalyzing a physiological reaction in vivo, comprising:
-
providing an implantable device having a body and a surface thereon adapted to be placed adjacent to a biological tissue or fluid in vivo, and having at least one chemical moiety attached to the surface, wherein the moiety is capable of catalyzing a first reaction upon contacting a first substrate in the biological tissue or fluid and remaining attached to the surface after the first reaction, and is capable of catalyzing a second reaction upon contact with a second substrate; and implanting the device into an animal or human such that the moiety contacts a biologically activatable substrate to catalyze a physiological reaction.
-
Specification