Aryl carboxamide derivatives as TTX-S blockers

• US 9,051,296 B2
• Filed: 11/16/2010
• Issued: 06/09/2015
• Est. Priority Date: 11/16/2009
• Status: Expired due to Fees

• Current Assignee: RaQualia Pharma Inc.
• Original Assignee: RaQualia Pharma Inc.
• Inventors: Yamagishi, Tatsuya, Arano, Yoshimasa, Morita, Mikio, Inoue, Tadashi
• Primary Examiner(s): Ward, Paul V
• Application Number:
  US13/509,442
• Publication Number:
  US 20120232052A1
• Time in Patent Office: 1,666 Days
• Field of Search: 514/277, 546/100, 548/400, 549/400
• US Class Current: 1/1
• CPC Class Codes: A61K 31/435 having six-membered rings with one nitrogen as the only ring hetero atom
• CPC Class Codes: A61K 31/44 Non condensed pyridines; Hydrogenated derivatives thereof
• CPC Class Codes: A61K 31/445 Non condensed piperidines, e.g. piperocaine
• CPC Class Codes: A61K 31/4525 containing a five-membered ring with oxygen as a ring hetero atom
• CPC Class Codes: A61K 31/4535 containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
• CPC Class Codes: A61K 31/454 containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
• CPC Class Codes: A61K 31/4545 containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
• CPC Class Codes: A61K 31/4709 Non-condensed quinolines and containing further heterocyclic rings
• CPC Class Codes: A61K 31/4725 containing further heterocyclic rings
• CPC Class Codes: A61K 31/4745 condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines yohimbine derivatives, vinblastine A61K31/475; ergoline derivatives A61K31/48
• CPC Class Codes: A61K 31/498 Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
• CPC Class Codes: A61K 31/4985 Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
• CPC Class Codes: A61K 31/506 not condensed and containing further heterocyclic rings
• CPC Class Codes: A61K 31/519 ortho- or peri-condensed with heterocyclic rings
• CPC Class Codes: A61K 31/5383 ortho- or peri-condensed with heterocyclic ring systems
• CPC Class Codes: A61P 1/00 Drugs for disorders of the alimentary tract or the digestive system
• CPC Class Codes: A61P 1/18 for pancreatic disorders, e.g. pancreatic enzymes
• CPC Class Codes: A61P 13/00 Drugs for disorders of the urinary system
• CPC Class Codes: A61P 13/10 of the bladder
• CPC Class Codes: A61P 15/00 Drugs for genital or sexual disorders for disorders of sex hormones A61P5/24; Contraceptives
• CPC Class Codes: A61P 19/02 : for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 21/02 : Muscle relaxants, e.g. for tetanus or cramps
• CPC Class Codes: A61P 25/00 : Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/04 : Centrally acting analgesics, e.g. opioids
• CPC Class Codes: A61P 25/06 : Antimigraine agents
• CPC Class Codes: A61P 25/08 : Antiepileptics; Anticonvulsants
• CPC Class Codes: A61P 25/14 : for treating abnormal movements, e.g. chorea, dyskinesia
• CPC Class Codes: A61P 25/16 : Anti-Parkinson drugs
• CPC Class Codes: A61P 25/18 : Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
• CPC Class Codes: A61P 25/20 : Hypnotics; Sedatives
• CPC Class Codes: A61P 25/22 : Anxiolytics
• CPC Class Codes: A61P 25/24 : Antidepressants
• CPC Class Codes: A61P 25/28 : for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• CPC Class Codes: A61P 29/00 : Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 35/00 : Antineoplastic agents
• CPC Class Codes: A61P 43/00 : Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 9/00 : Drugs for disorders of the cardiovascular system
• CPC Class Codes: A61P 9/06 : Antiarrhythmics
• CPC Class Codes: C07D 211/46 : having a hydrogen atom as the second substituent in position 4
• CPC Class Codes: C07D 401/06 : linked by a carbon chain containing only aliphatic carbon atoms
• CPC Class Codes: C07D 401/10 : linked by a carbon chain containing aromatic rings
• CPC Class Codes: C07D 401/12 : linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 401/14 : containing three or more hetero rings
• CPC Class Codes: C07D 405/06 : linked by a carbon chain containing only aliphatic carbon atoms
• CPC Class Codes: C07D 405/12 : linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 405/14 : containing three or more hetero rings
• CPC Class Codes: C07D 409/06 : linked by a carbon chain containing only aliphatic carbon atoms
• CPC Class Codes: C07D 413/06 : linked by a carbon chain containing only aliphatic carbon atoms
• CPC Class Codes: C07D 417/06 : linked by a carbon chain containing only aliphatic carbon atoms
• CPC Class Codes: C07D 417/10 : linked by a carbon chain containing aromatic rings
• CPC Class Codes: C07D 455/04 : containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
• CPC Class Codes: C07D 471/04 : Ortho-condensed systems
• CPC Class Codes: C07D 471/06 : Peri-condensed systems
• CPC Class Codes: C07D 487/04 : Ortho-condensed systems
• CPC Class Codes: C07D 491/048 : the oxygen-containing ring being five-membered
• CPC Class Codes: C07D 495/04 : Ortho-condensed systems
• CPC Class Codes: C07D 498/04 : Ortho-condensed systems
• CPC Class Codes: C07D 513/04 : Ortho-condensed systems

Abstract

The present invention relates to aryl carboxamide derivatives of formula (I), wherein Ar¹ is phenyl; Ar² is aryl; n is 1-4; X is —O—, —S—, —SO— or —SO₂—, a prodrug thereof or a pharmaceutically acceptable salt thereof, which have blocking activities of voltage gated sodium channels as the TTX-S channels, and which are useful in the treatment or prevention of such disorders and diseases as pain in which voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases as pain in which voltage gated sodium channels are involved.

Claims

1. A compound of formula (I)

5. A pharmaceutical composition comprising the compound or the pharmaceutically acceptable salt thereof, as claimed in claim 1, and a pharmaceutically acceptable carrier.

6. A pharmaceutical composition as claimed in claim 5, further comprising another pharmacologically active agent.

2. A compound of formula (I)

3. A compound which is selected from:

(4-(4-chlorophenoxyl)piperidin-1-yl)(8-hydroxyquinolin-2-yl)methanone;

(4-(2-chlorophenoxyl)piperidin-1-yl)(8-hydroxyquinolin-2-yl)methanone;

(4-(3-chlorophenoxyl)piperidin-1-yl)(8-hydroxyquinolin-2-yl)methanone;

(8-hydroxyquinolin-2-yl)(4-(o-tolyloxy)piperidin-1-yl)methanone;

(8-hydroxyquinolin-2-yl)(4-(m-tolyloxy)piperidin-1-yl)methanone;

(8-hydroxyquinolin-2-yl)(4-(p-tolyloxy)piperidin-1-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(quinolin-2-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(4-hydroxyquinolin-2-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(quinolin-6-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(quinolin-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(isoquinolin-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1,6-naphthyridin-2-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(isoquinolin-1-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(quinolin-4-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(6-(2,2,2-trifluoroethoxyl)pyridin-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(6-methylpyridin-2-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(3,5-difluoropyridin-2-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(5-methylpyridin-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(quinoxalin-6-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(6-phenoxypyridin-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(quinolin-8-yl)methanone;

benzo[c]isoxazol-3-yl(4-(4-chlorophenoxyl)piperidin-1-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1-isopropyl-1H-benzo[d][1,2,3]triazol-5-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(5-fluoro-1H-indol-2-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(6-fluoro-1H-indol-2-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(5-isobutylisoxazol-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2-methyl-5-phenylfuran-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(3-(2-methylthiazol-4-yl)phenyl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(5-methoxy-1H-indol-2-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1H-indol-4-yl)methanone;

(3-(1H-pyrazol-1-yl)phenyl)(4-(4-chlorophenoxyl)piperidin-1-yl)methanone;

(4-(1H-1,2,4-triazol-1-yl)phenyl)(4-(4-chlorophenoxyl)piperidin-1-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(5-methyl-2-phenyl-2H-1,2,3-triazol-4-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(4,5-dichloroisothiazol-3-yl)methanone;

benzofuran-2-yl(4-(4-chlorophenoxyl)piperidin-1-yl)methanone;

benzo[b]thiophen-2-yl(4-(4-chlorophenoxyl)piperidin-1-yl)methanone;

(8-hydroxyquinolin-2-yl)(4-(2-methoxyphenoxyl)piperidin-1-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(4-methyl-2-phenylpyrimidin-5-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(6-phenylpyrimidin-4-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(4-methoxyquinolin-2-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(quinoxalin-2-yl)methanone;

benzo[d]thiazol-6-yl(4-(4-chlorophenoxyl)piperidin-1-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1H-indol-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1H-indol-2-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1-methyl-1H-indol-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1-methyl-1H-indol-2-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2,3-dimethyl-1H-indol-5-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1H-indol-6-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2-methyl-1H-benzo[d]imidazol-5-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(imidazo[1,2-a]pyridin-2-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2-methylimidazo[1,2-a]pyridin-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(5-methyl-1-phenyl-1H-pyrazol-4-yl)methanone;

(4-(tert-butyl)phenyl)(4-(4-chlorophenoxyl)piperidin-1-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(4-chlorophenyl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(4-fluorophenyl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(3-(5-fluoro-1H-benzo[d]imidazol-2-yl)phenyl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(3-(1-methyl-1H-benzo[d]imidazol-2-yl)phenyl)methanone;

(4-(2-fluorophenoxyl)piperidin-1-yl)(8-hydroxyquinolin-2-yl)methanone;

(4-(3-fluorophenoxyl)piperidin-1-yl)(8-hydroxyquinolin-2-yl)methanone;

(4-(4-fluorophenoxyl)piperidin-1-yl)(8-hydroxyquinolin-2-yl)methanone;

(8-hydroxyquinolin-2-yl)(4-(3-methoxyphenoxyl)piperidin-1-yl)methanone;

2-((1-(8-hydroxyquinoline-2-carbonyl)piperidin-4-yl)oxy)benzonitrile;

4-((1-(8-hydroxyquinoline-2-carbonyl)piperidin-4-yl)oxy)benzonitrile;

3-((1-(8-hydroxyquinoline-2-carbonyl)piperidin-4-yl)oxy)benzonitrile;

(4-(4-chlorophenoxyl)piperidin-1-yl)(8-methoxyquinolin-2-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1-methyl-1H-indol-7-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1-methyl-1H-indol-4-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1,8-naphthyridin-2-yl)methanone;

(8-hydroxyquinolin-2-yl)(4-phenoxypiperidin-1-yl)methanone;

(8-hydroxyquinolin-2-yl)(4-(2-(trifluoromethyl)phenoxy)piperidin-1-yl)methanone;

(8-hydroxyquinolin-2-yl)(4-(3-(trifluoromethyl)phenoxy)piperidin-1-yl)methanone;

(5-(tert-butyl)isoxazol-3-yl)(4-(4-chlorophenoxyl)piperidin-1-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(5-phenylisoxazol-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(5-cyclopropylisoxazol-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(3,5-dimethylisoxazol-4-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1-methyl-1H-indazol-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2-methyl-2H-indazol-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(cinnolin-4-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2-methyl-4-phenylpyrimidin-5-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(6-methylpyridin-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(pyridin-4-yl)methanone;

[1,2,4]triazolo[1,5-a]pyrimidin-2-yl(4-(4-chlorophenoxyl)piperidin-1-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1,2,3-trimethyl-1H-indol-5-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1-methyl-1H-indol-6-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2-methylthiazol-4-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(6-methoxypyridin-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2-phenoxypyridin-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1H-indol-7-yl)methanone;

7-(4-(4-chlorophenoxy)piperidine-1-carbonyl)indoline-2,3-dione;

(4-(4-chlorophenoxyl)piperidin-1-yl)(3-methylpyridin-2-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(6-hydroxypyridin-2-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2,4-dimethylthiazol-5-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(5-methyl-1,3,4-oxadiazol-2-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1H-indazol-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(4,5,6,7-tetrahydro-1H-indazol-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(6-methoxypyridin-2-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2-methyl-4,5,6,7-tetrahydro-2H-indazol-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(isoquinolin-4-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(4-methylpyridin-2-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(6-methoxyquinolin-2-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(6-methoxy-2-methylquinolin-3-yl)methanone;

benzo[d]isoxazol-3-yl(4-(4-chlorophenoxyl)piperidin-1-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2-(trifluoromethyl)-1H-benzo[d]imidazol-5-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1,5-naphthyridin-2-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2-methyl-6-phenylpyridin-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1,5-dimethyl-1H-indol-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(5-fluoro-1-methyl-1H-indol-3-yl)methanone;

(5-chloro-1-methyl-1H-indol-3-yl)(4-(4-chlorophenoxyl)piperidin-1-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(5-methoxy-1-methyl-1H-indol-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1,6-dimethyl-1H-indol-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(6-fluoro-1-methyl-1H-indol-3-yl)methanone;

(6-chloro-1-methyl-1H-indol-3-yl)(4-(4-chlorophenoxyl)piperidin-1-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(6-methoxy-1-methyl-1H-indol-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(5-fluoro-1-methyl-1H-indol-2-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(5-methoxy-1-methyl-1H-indol-2-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(3-fluorophenyl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(p-tolyl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(4-methoxyphenyl)methanone;

4-(4-(4-chlorophenoxy)piperidine-1-carbonyl)benzonitrile;

(4-(4-chlorophenoxyl)piperidin-1-yl)(6-methylimidazo[1,2-a]pyridin-2-yl)methanone;

(6-chloroimidazo[1,2-a]pyridin-2-yl)(4-(4-chlorophenoxy)piperidin-1-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2-methylpyridin-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(4-isopropoxyphenyl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(4-(trifluoromethoxy)phenyl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(4-(methylsulfonyl)phenyl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(3-methoxyphenyl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(pyridin-2-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(5-methylisoxazol-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(oxazol-4-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(4-methylthiazol-5-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(5-methylpyrazin-2-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(6-fluoro-1-methyl-1H-indol-2-yl)methanone;

4-(4-(4-chlorophenoxy)piperidine-1-carbonyl)-N,N-dimethylbenzenesulfonamide;

4-(4-(4-chlorophenoxy)piperidine-1-carbonyl)benzamide;

(4-(4-chlorophenoxyl)piperidin-1-yl)(5-fluoro-1H-indazol-3-yl)methanone;

(5-chloro-1H-indazol-3-yl)(4-(4-chlorophenoxyl)piperidin-1-yl)methanone;

(6-chloro-1H-indazol-3-yl)(4-(4-chlorophenoxyl)piperidin-1-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(4-(2-hydroxypropan-2-yl)phenyl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2,6-dimethoxypyridin-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(6-methoxy-1-methyl-1H-indol-2-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1-methyl-5-(trifluoromethoxy)-1H-indol-2-yl)methanone;

2-(4-(4-chlorophenoxy)piperidine-1-carbonyl)-1-methyl-1H-indole-5-carbonitrile;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1-methyl-5-(methylsulfonyl)-1H-indol-2-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(4-methylpyridin-3-yl)methanone;

3-(4-(4-chlorophenoxy)piperidine-1-carbonyl)-5,6-dimethylpyridin-2(1H)-one;

(4-(4-chlorophenoxyl)piperidin-1-yl)(quinolin-5-yl)methanone;

(4-(4-fluorophenoxyl)piperidin-1-yl)(2-methyl-2H-indazol-3-yl)methanone;

(4-(4-fluorophenoxyl)piperidin-1-yl)(6-methoxypyridin-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(3-methoxy-4-methylphenyl)methanone;

(5-chloro-4-methoxythiophen-3-yl)(4-(4-chlorophenoxyl)piperidin-1-yl)methanone;

(4-phenoxypiperidin-1-yl)(quinolin-8-yl)methanone;

(4-(4-fluorophenoxyl)piperidin-1-yl)(imidazo[1,2-a]pyridin-2-yl)methanone;

(4-(4-fluorophenoxyl)piperidin-1-yl)(quinolin-8-yl)methanone;

(6-aminopyridin-3-yl)(4-(4-chlorophenoxy)piperidin-1-yl)methanone;

(5-bromopyridin-3-yl)(4-(4-chlorophenoxyl)piperidin-1-yl)methanone;

(5-bromopyridin-2-yl)(4-(4-chlorophenoxyl)piperidin-1-yl)methanone;

1-(4-(4-(4-chlorophenoxy)piperidine-1-carbonyl)phenyl)ethanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(3,4-dimethoxyphenyl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(isoquinolin-5-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(phenyl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(m-tolyl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2-methoxyphenyl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(3-(trifluoromethoxy)phenyl)methanone;

(1H-benzo[d]imidazol-5-yl)(4-(4-chlorophenoxyl)piperidin-1-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1,5-dimethyl-1H-pyrazol-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1,3-dimethyl-1H-pyrazol-5-yl)methanone;

(3-(tert-butyl)-1-methyl-1H-pyrazol-5-yl)(4-(4-chlorophenoxyl)piperidin-1-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1-(4-methoxyphenyl)-5-methyl-1H-pyrazol-4-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1-(2-methoxyphenyl)-1H-pyrazol-4-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(3,5-dimethyl-1H-pyrazol-4-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1H-1,2,4-triazol-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(5-isopropyl-1H-pyrazol-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(imidazo[2,1-b]thiazol-6-yl)methanone;

(4-(3-methoxyphenoxyl)piperidin-1-yl)(quinolin-8-yl)methanone;

imidazo[1,2-a]pyridin-2-yl(4-(3-methoxyphenoxyl)piperidin-1-yl)methanone;

(4-(3-fluorophenoxyl)piperidin-1-yl)(quinolin-8-yl)methanone;

(4-(3-fluorophenoxyl)piperidin-1-yl)(imidazo[1,2-a]pyridin-2-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(5-chloropyridin-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(5-methoxypyridin-3-yl)methanone;

3-(4-(4-chlorophenoxy)piperidine-1-carbonyl)benzonitrile;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2-ethoxypyridin-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2-methoxypyridin-4-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(isoquinolin-8-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2-methylthiazol-5-yl)methanone;

(4-((4-chlorophenyl)thio)piperidin-1-yl)(quinolin-8-yl)methanone;

(4-((4-chlorophenyl)thio)piperidin-1-yl)(6-methylpyridin-3-yl)methanone;

(4-((4-chlorophenyl)sulfonyl)piperidin-1-yl)(quinolin-8-yl)methanone;

1-(3-((1-(quinoline-8-carbonyl)piperidin-4-yl)oxy)phenyl)ethanone;

(4-(3,5-dimethoxyphenoxyl)piperidin-1-yl)(quinolin-8-yl)methanone;

quinolin-8-yl(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(3-methylisoxazol-5-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1-isopropyl-1H-pyrazol-4-yl)methanone;

5-(4-(4-chlorophenoxy)piperidine-1-carbonyl)picolinonitrile;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2-hydroxyquinolin-4-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(5-(trifluoromethyl)-1H-pyrazol-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(5-cyclopropyl-1H-pyrazol-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(5-(2-methoxyphenyl)-1H-pyrazol-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(3-isopropyl-1-methyl-1H-pyrazol-5-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(3-ethyl-1-methyl-1H-pyrazol-5-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1-ethyl-3-methyl-1H-pyrazol-5-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2-methyloxazol-4-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(thieno[3,2-b]pyridin-2-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(imidazo[1,2-a]pyridin-6-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1-methyl-1H-indazol-6-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(6-(trifluoromethoxy)-1H-indazol-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1-methyl-6-(trifluoromethoxy)-1H-indazol-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2,4-dimethyloxazol-5-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(5-methoxypyridin-2-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(imidazo[1,2-a]pyridin-7-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(imidazo[1,2-a]pyrazin-2-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2-methyl-2H-indazol-6-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(6-(pyrrolidin-1-yl)pyridin-2-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(5-(pyrrolidin-1-yl)pyridin-2-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(4-fluoro-3-methoxyphenyl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(4-methyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(6-(piperidin-1-yl)pyridin-3-yl)methanone;

3-(4-(4-chlorophenoxy)piperidine-1-carbonyl)quinolin-2(1H)-one;

(4-(4-chlorophenoxyl)piperidin-1-yl)(imidazo[1,2-a]pyridin-8-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(pyrazolo[1,5-a]pyridin-7-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(4-(trifluoromethyl)pyridin-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1-methyl-1H-imidazol-2-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1-(2-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)methanone;

3-(4-(4-chlorophenoxy)piperidine-1-carbonyl)-1-methylquinolin-4(1H)-one;

(4-(4-chlorophenoxyl)piperidin-1-yl)(pyrimidin-4-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(5-chloropyridin-2-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2-methoxyquinolin-4-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(5-hydroxypyridin-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(6-(trifluoromethyl)pyridin-3-yl)methanone;

(5-aminopyridin-3-yl)(4-(4-chlorophenoxy)piperidin-1-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(imidazo[1,2-a]pyrimidin-2-yl)methanone;

N-(5-(4-(4-chlorophenoxy)piperidine-1-carbonyl)pyridin-3-yl)acetamide;

(4-(4-chlorophenoxyl)piperidin-1-yl)(chroman-6-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1-methyl-1H-pyrazolo[3,4-b]pyridin-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1-methyl-1H-indol-5-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(3-(pyridin-2-yloxy)phenyl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1-methyl-1H-benzo[d]imidazol-5-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(4-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(pyrazolo[1,5-a]pyridin-2-yl)methanone;

1-(3-(4-(4-chlorophenoxy)piperidine-1-carbonyl)-1H-pyrazol-5-yl)ethanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1,3,5-trimethyl-1H-pyrazol-4-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1H-pyrrolo[2,3-b]pyridin-2-yl)methanone;

4-(4-(4-chlorophenoxy)piperidine-1-carbonyl)-1-methylquinolin-2(1H)-one;

5-(4-(4-chlorophenoxy)piperidine-1-carbonyl)-1H-benzo[d]imidazol-2(3H)-one;

(4-(4-chlorophenoxyl)piperidin-1-yl)(5-methoxypyrazin-2-yl)methanone;

5-(4-(4-chlorophenoxy)piperidine-1-carbonyl)-1,3-dimethyl-1H-benzo[d]imidazol-2(3H)-one;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1-methyl-1H-imidazol-4-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2-phenyl-1H-imidazol-4-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1,3-dimethyl-1H-pyrazol-4-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1,5-dimethyl-1H-pyrazol-4-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(3-isobutyl-1-methyl-1H-pyrazol-5-yl)methanone;

(4-chloro-5-methyl-1H-pyrazol-3-yl)(4-(4-chlorophenoxy)piperidin-1-yl)methanone;

3-(4-(4-chlorophenoxy)piperidine-1-carbonyl)-1-isopropyl-6,7-dihydro-1H-cyclopenta[b]pyridin-2(5H)-one;

5-(4-(4-chlorophenoxy)piperidine-1-carbonyl)-2-methoxybenzonitrile;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2-isopropylthiazol-4-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(5,6-dimethoxy-1H-indol-2-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2,7-dimethylpyrazolo[1,5-a]pyrimidin-6-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1H-pyrrolo[2,3-b]pyridin-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1-methyl-1H-pyrrolo[2,3-b]pyridin-2-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(5,6-dimethoxy-1-methyl-1H-indol-2-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methanone;

3-(4-(4-chlorophenoxy)piperidine-1-carbonyl)-1-isopropyl-4-methylquinolin-2(1H)-one;

(4-(4-chlorophenoxyl)piperidin-1-yl)(4-methyl-4H-furo[3,2-b]pyrrol-5-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(4-methyl-4H-thieno[3,2-b]pyrrol-5-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1,3-dimethyl-1H-thieno[2,3-c]pyrazol-5-yl)methanone;

2-(4-(4-chlorophenoxy)piperidine-1-carbonyl)-6,7-dihydropyrido[3,2,1-ij]quinolin-3 (5H)-one;

5-(4-(4-chlorophenoxy)piperidine-1-carbonyl)-1H-pyrrolo[3,2,1-ij]quinolin-4(2H)-one;

3-(4-(4-chlorophenoxy)piperidine-1-carbonyl)-1-ethyl-7-methyl-1,8-naphthyridin-4(1H)-one;

(4-(4-chlorophenoxyl)piperidin-1-yl)(isoquinolin-6-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(5-methylpyridin-2-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(5-(2,2,2-trifluoroethoxyl)pyridin-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(3-methylisoxazolo[5,4-b]pyridin-5-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1,3,6-trimethyl-1H-pyrazolo[3,4-b]pyridin-4-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(thieno[2,3-b]pyridin-2-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(thieno[2,3-b]pyrazin-6-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(pyrazolo[1,5-a]pyrimidin-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2-(pyrrolidin-1-yl)pyrimidin-5-yl)methanone;

(1H-benzo[d]imidazol-4-yl)(4-(4-chlorophenoxyl)piperidin-1-yl)methanone;

benzo[d][1,2,3]thiadiazol-7-yl(4-(4-chlorophenoxyl)piperidin-1-yl)methanone;

3-(4-(4-chlorophenoxy)piperidine-1-carbonyl)-1-methylquinolin-2(1H)-one;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1-methyl-1H-benzo[d]imidazol-2-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(pyrazolo[1,5-a]pyrimidin-2-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2-methoxypyrimidin-5-yl)methanone;

(1H-benzo[d][1,2,3]triazol-4-yl)(4-(4-chlorophenoxyl)piperidin-1-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(6-methylimidazo[2,1-b]thiazol-5-yl)methanone;

benzo[c][1,2,5]thiadiazol-4-yl(4-(4-chlorophenoxyl)piperidin-1-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1-(2-methoxyethyl)-1H-indol-5-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1-(2-methoxyethyl)-1H-indol-6-yl)methanone;

(3-amino-1-methyl-1H-pyrazol-5-yl)(4-(4-chlorophenoxyl)piperidin-1-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(5-cyclopropyl-1-methyl-1H-pyrazol-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(3-cyclopropyl-1-methyl-1H-pyrazol-5-yl)methanone;

1-benzyl-3-(4-(4-chlorophenoxy)piperidine-1-carbonyl)pyridin-2(1H)-one;

(1-benzyl-1H-pyrazol-4-yl)(4-(4-chlorophenoxyl)piperidin-1-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1-(2-methoxyethyl)-1H-indol-2-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1-(2-methoxyethyl)-1H-indol-4-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(3,6-dimethylisoxazolo[5,4-b]pyridin-4-yl)methanone;

4-(4-(4-chlorophenoxy)piperidine-1-carbonyl)-1-methylpyridin-2(1H)-one;

3-(4-(4-chlorophenoxy)piperidine-1-carbonyl)-4H-pyrido[1,2-a]pyrimidin-4-one;

3-(4-(4-chlorophenoxy)piperidine-1-carbonyl)isoquinolin-1 (2H)-one;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2-(3,5-dimethyl-1H-pyrazol-4-yl)phenyl)methanone;

benzo[c][1,2,5] oxadiazol-5-yl(4-(4-chlorophenoxyl)piperidin-1-yl)methanone;

(6-aminopyridin-2-yl)(4-(4-chlorophenoxy)piperidin-1-yl)methanone;

3-(4-(4-chlorophenoxy)piperidine-1-carbonyl)-1,6-dimethylpyridin-2(1H)-one;

(4-(4-chlorophenoxyl)piperidin-1-yl)(3-propoxypyridin-2-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(6-((tetrahydro-2H-pyran-4-yl)oxy)pyridin-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(6-((tetrahydro-2H-pyran-4-yl)oxy)pyridin-2-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(5-((tetrahydro-2H-pyran-4-yl)oxy)pyridin-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(3-hydroxy-4-methoxyphenyl)methanone;

(4-chloro-2-hydroxyphenyl)(4-(4-chlorophenoxyl)piperidin-1-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(4-hydroxy-3-methylphenyl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(6-morpholinopyridin-2-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2-morpholinopyridin-4-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2-hydroxy-4-(trifluoromethyl)phenyl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(3-hydroxy-4-methylphenyl)methanone;

tert-butyl ((2-(4-(4-chlorophenoxyl)piperidine-1-carbonyl)pyridin-4-yl)methyl)carbamate;

(4-(aminomethyl)pyridin-2-yl)(4-(4-chlorophenoxyl)piperidin-1-yl)methanone;

N-((2-(4-(4-chlorophenoxy)piperidine-1-carbonyl)pyridin-4-yl)methyl)pivalamide;

N-((2-(4-(4-chlorophenoxy)piperidine-1-carbonyl)pyridin-4-yl)methyl)-4-fluorobenzamide;

N-((2-(4-(4-chlorophenoxy)piperidine-1-carbonyl)pyridin-4-yl)methyl)-4-fluorobenzenesulfonamide;

tert-butyl 2-(4-(4-chlorophenoxyl)piperidine-1-carbonyl)-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate;

(4-(4-chlorophenoxyl)piperidin-1-yl)(6-(methylsulfonyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl)methanone;

N-(tert-butyl)-4-(4-(4-chlorophenoxyl)piperidine-1-carbonyl)benzamide;

N-(tert-butyl)-4-(4-(4-chlorophenoxyl)piperidine-1-carbonyl)-N-methylbenzamide;

4-(4-(4-chlorophenoxy)piperidine-1-carbonyl)-N-(2,2,2-trifluoroethyl)benzamide;

(4-(4-chlorophenoxyl)piperidin-1-yl)(4-(2-methoxyethoxyl)phenyl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(4-(2-hydroxyethoxyl)phenyl)methanone;

N-(4-(4-(4-chlorophenoxy)piperidine-1-carbonyl)benzyl)pivalamide;

4-(4-(4-chlorophenoxy)piperidine-1-carbonyl)picolinamide;

(4-(4-chlorophenoxyl)piperidin-1-yl)(5-morpholinopyridin-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(6-(piperidin-1-yl)pyrimidin-4-yl)methanone;

(3-(1H-imidazol-1-yl)phenyl)(4-(4-chlorophenoxyl)piperidin-1-yl)methanone;

(2-(1H-pyrazol-1-yl)phenyl)(4-(4-chlorophenoxyl)piperidin-1-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2-(2-methyl-1H-imidazol-1-yl)phenyl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(3-methyl-1H-pyrazol-5-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(6-(piperidine-1-carbonyl)pyridin-2-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2-hydroxy-4-methoxyphenyl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(4-hydroxy-3-methoxyphenyl)methanone;

N-(5-chloro-2-(4-(4-chlorophenoxyl)piperidine-1-carbonyl)phenyl)methanesulfonamide;

N-(4-chloro-2-(4-(4-chlorophenoxyl)piperidine-1-carbonyl)phenyl)methanesulfonamide;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2′

-(hydroxymethyl)-[1,1′

-biphenyl]-4-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2′

-(methylsulfonyl)-[1,1′

-biphenyl]-4-yl)methanone;

(3-chloro-4-hydroxyphenyl)(4-(4-chlorophenoxyl)piperidin-1-yl)methanone;

3-(tert-butyl)-5-(4-(4-chlorophenoxyl)piperidine-1-carbonyl)benzamide;

3-(tert-butyl)-5-(4-(4-chlorophenoxyl)piperidine-1-carbonyl)-N,N-dimethylbenzamide;

(3-(tert-butyl)-5-(4-(4-chlorophenoxy)piperidine-1-carbonyl)phenyl)(morpholino)methanone;

4′

-(4-(4-chlorophenoxy)piperidine-1-carbonyl)-[1,1′

-biphenyl]-3-carboxamide;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1-(2-morpholinoethyl)-1H-indol-5-yl)methanone;

2-(5-(4-(4-chlorophenoxy)piperidine-1-carbonyl)-1H-indol-1-yl)-N,N-dimethylacetamide;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1-(2-hydroxyethyl)-1H-indol-5-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(4-morpholinopyridin-2-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(4-(piperidin-1-yl)pyridin-2-yl)methanone;

2-(3-(4-(4-chlorophenoxy)piperidine-1-carbonyl)-1H-indol-1-yl)-N,N-dimethylacetamide;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1-(2-hydroxyethyl)-1H-indol-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1-(2-morpholinoethyl)-1H-indol-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1-(2-(piperidin-1-yl)ethyl)-1H-indol-3-yl)methanone;

2-(4-(4-(4-chlorophenoxy)piperidine-1-carbonyl)phenyl)-2-methylpropanenitrile;

(4-(4-chlorophenoxyl)piperidin-1-yl)(3-fluoro-4-hydroxyphenyl)methanone;

2-chloro-5-(4-(4-chlorophenoxyl)piperidine-1-carbonyl)benzenesulfonamide;

4′

-(4-(4-chlorophenoxy)piperidine-1-carbonyl)-[1,1′

-biphenyl]-4-carboxamide;

4′

-(4-(4-chlorophenoxy)piperidine-1-carbonyl)-[1,1′

-biphenyl]-2-carboxamide;

(5-chloro-2-hydroxyphenyl)(4-(4-chlorophenoxyl)piperidin-1-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2-hydroxy-4-methylphenyl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(5-fluoro-2-hydroxyphenyl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2-hydroxy-3-methylphenyl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2-hydroxy-3-isopropylphenyl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2-hydroxy-6-methoxyphenyl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2-fluoro-6-hydroxyphenyl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(3-hydroxy-2-methylphenyl)methanone;

(2-chloro-4-hydroxyphenyl)(4-(4-chlorophenoxyl)piperidin-1-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2-fluoro-4-hydroxyphenyl)methanone;

N-(4-(4-(4-chlorophenoxy)piperidine-1-carbonyl)-2-methylphenyl)methanesulfonamide;

(4-(4-chlorophenoxyl)piperidin-1-yl)(4-fluoro-3-hydroxyphenyl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2-hydroxy-5-methylphenyl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2-hydroxy-3-methoxyphenyl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(4-fluoro-2-hydroxyphenyl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(3,5-dihydroxyphenyl)methanone;

N-(3-(4-(4-chlorophenoxy)piperidine-1-carbonyl)phenyl)acetamide;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1-((4-hydroxytetrahydro-2H-pyran-4-yl)methyl)-1H-indol-5-yl)methanone;

(1-(2-aminoethyl)-1H-indol-5-yl)(4-(4-chlorophenoxyl)piperidin-1-yl)methanone;

N-(2-(5-(4-(4-chlorophenoxyl)piperidine-1-carbonyl)-1H-indol-1-yl)ethyl)acetamide;

N-(2-(5-(4-(4-chlorophenoxyl)piperidine-1-carbonyl)-1H-indol-1-yl)ethyl)methanesulfonamide;

2-(5-(4-(4-chlorophenoxy)piperidine-1-carbonyl)-1H-indol-1-yl)-1-morpholinoethanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(3′

-(methylsulfonyl)-[1,1′

-biphenyl]-4-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(3′

-(hydroxymethyl)-[1,1′

-biphenyl]-4-yl)methanone;

N-(4′

-(4-(4-chlorophenoxy)piperidine-1-carbonyl)-[1,1′

-biphenyl]-2-yl)methanesulfonamide;

N-(4′

-(4-(4-chlorophenoxy)piperidine-1-carbonyl)-[1,1′

-biphenyl]-3-yl)methanesulfonamide;

4′

-(4-(4-chlorophenoxy)piperidine-1-carbonyl)-N-methyl-[1,1′

-biphenyl]-3-carboxamide;

4′

-(4-(4-chlorophenoxy)piperidine-1-carbonyl)-N,N-dimethyl-[1,1′

-biphenyl]-3-carboxamide;

(4-(4-chlorophenoxyl)piperidin-1-yl)(3′

-(morpholine-4-carbonyl)-[1,1′

-biphenyl]-4-yl)methanone;

(4-chloro-3-hydroxyphenyl)(4-(4-chlorophenoxyl)piperidin-1-yl)methanone;

N-(5-(4-(4-chlorophenoxy)piperidine-1-carbonyl)-2-methylphenyl)methanesulfonamide;

1-(3-(4-(4-chlorophenoxy)piperidine-1-carbonyl)phenyl)ethanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1-(2-hydroxyethyl)-2-methyl-1H-benzo[d]imidazol-5-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(6-ethoxypyridin-2-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(4-hydroxy-7-methyl-1,8-naphthyridin-3-yl)methanone;

N-(6-(4-(4-chlorophenoxy)piperidine-1-carbonyl)pyridin-2-yl)acetamide;

N-(4-(4-(4-chlorophenoxy)piperidine-1-carbonyl)pyridin-2-yl)acetamide;

N-(5-(4-(4-chlorophenoxy)piperidine-1-carbonyl)pyridin-2-yl)acetamide;

(4-(4-chlorophenoxyl)piperidin-1-yl)(3-hydroxypyridin-2-yl)methanone;

(4-bromo-1-methoxynaphthalen-2-yl)(4-(4-chlorophenoxyl)piperidin-1-yl)methanone;

6-(4-(4-chlorophenoxy)piperidine-1-carbonyl)isoindolin-1-one;

(4-(4-chlorophenoxyl)piperidin-1-yl)(quinoxalin-5-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1,6-naphthyridin-5-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(4-hydroxyphenyl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(4-ethoxy-2-hydroxyphenyl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(3-hydroxyphenyl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2-hydroxyphenyl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(4-hydroxy-3,5-dimethoxyphenyl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(4-hydroxy-2-methylphenyl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(5-hydroxy-2-methylphenyl)methanone;

(3-chloro-2-hydroxyphenyl)(4-(4-chlorophenoxyl)piperidin-1-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(3-fluoro-2-hydroxyphenyl)methanone;

2-(5-(4-(4-chlorophenoxy)piperidine-1-carbonyl)-2-methylphenoxy)acetamide;

2-(2-(4-(4-chlorophenoxy)piperidine-1-carbonyl)-5-methylphenoxy)acetamide;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2,6-dihydroxyphenyl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2-fluoro-3-hydroxyphenyl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2-fluoro-5-hydroxyphenyl)methanone;

(2-chloro-5-hydroxyphenyl)(4-(4-chlorophenoxyl)piperidin-1-yl)methanone;

(3-(tert-butyl)-1-methyl-1H-pyrazol-5-yl)(4-(4-fluorophenoxyl)piperidin-1-yl)methanone;

(4-fluoro-3-methoxyphenyl)(4-(4-fluorophenoxyl)piperidin-1-yl)methanone;

(4-((4-chlorophenyl)sulfonyl)piperidin-1-yl)(2-methyl-2H-indazol-3-yl)methanone;

(4-(4-fluorophenoxyl)piperidin-1-yl)(4-fluorophenyl)methanone;

(5-(tert-butyl)isoxazol-3-yl)(4-(4-fluorophenoxyl)piperidin-1-yl)methanone;

(4-(4-fluorophenoxyl)piperidin-1-yl)(1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)methanone;

(4-(4-fluorophenoxyl)piperidin-1-yl)(1-methyl-1H-indazol-3-yl)methanone;

(4-(4-fluorophenoxyl)piperidin-1-yl)(quinoxalin-2-yl)methanone;

(4-(4-fluorophenoxyl)piperidin-1-yl)(4-methoxyquinolin-2-yl)methanone;

(4-(4-fluorophenoxyl)piperidin-1-yl)(6-methoxyquinolin-2-yl)methanone;

(4-(4-fluorophenoxyl)piperidin-1-yl)(isoquinolin-1-yl)methanone;

(4-(4-fluorophenoxyl)piperidin-1-yl)(isoquinolin-4-yl)methanone;

(4-(4-fluorophenoxyl)piperidin-1-yl)(quinolin-4-yl)methanone;

(5-aminopyridin-2-yl)(4-(4-chlorophenoxyl)piperidin-1-yl)methanone;

(6-(tert-butyl)pyridin-3-yl)(4-(4-chlorophenoxyl)piperidin-1-yl)methanone;

(6-(tert-butyl)pyridin-3-yl)(4-(4-fluorophenoxyl)piperidin-1-yl)methanone;

N-(6-(4-(4-chlorophenoxy)piperidine-1-carbonyl)pyridin-3-yl)acetamide;

(6-methylpyridin-3-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

(1,3-dimethyl-1H-pyrazol-5-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

(3,5-dimethylisoxazol-4-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

(6-hydroxypyridin-2-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

(3-methylpyridin-2-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

(5-methoxypyridin-3-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

(5-aminopyridin-3-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

(6-methoxypyridin-3-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

4-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)picolinamide;

(3-methylisoxazol-5-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

(2-methylthiazol-5-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

(1-methyl-1H-imidazol-4-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

(2-hydroxy-6-methoxyphenyl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

(2,4-dimethylthiazol-5-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

(2-methyl-2H-indazol-3-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

(2-methyl-2H-indazol-6-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

imidazo[1,2-a]pyridin-8-yl(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

(1,8-naphthyridin-2-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

(1,5-naphthyridin-2-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

(2-hydroxyquinolin-4-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

1,6-dimethyl-3-(4-((3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)pyridin-2(1H)-one;

benzo[d]thiazol-6-yl(4-(4-fluorophenoxyl)piperidin-1-yl)methanone;

(4-(4-fluorophenoxyl)piperidin-1-yl)(2-methyl-1H-benzo[d]imidazol-5-yl)methanone;

(4-(4-fluorophenoxyl)piperidin-1-yl)(1-methyl-1H-benzo[d]imidazol-5-yl)methanone;

(4-(4-fluorophenoxyl)piperidin-1-yl)(5-methoxypyridin-2-yl)methanone;

(4-(4-fluorophenoxyl)piperidin-1-yl)(4-methyl-2-phenylpyrimidin-5-yl)methanone;

(4-(4-fluorophenoxyl)piperidin-1-yl)(1-methyl-1H-benzo[d]imidazol-2-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(6-ethoxypyridin-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(6-(dimethylamino)pyridin-3-yl)methanone;

(4-((4-chlorophenyl)sulfonyl)piperidin-1-yl)(quinolin-2-yl)methanone;

(4-((4-chlorophenyl)sulfonyl)piperidin-1-yl)(quinolin-3-yl)methanone;

(4-((4-chlorophenyl)sulfonyl)piperidin-1-yl)(5-methyl-1-phenyl-1H-pyrazol-4-yl)methanone;

(4-((4-chlorophenyl)sulfonyl)piperidin-1-yl)(4-methoxyquinolin-2-yl)methanone;

(4-((4-chlorophenyl)sulfonyl)piperidin-1-yl)(6-ethoxypyridin-2-yl)methanone;

(6-methoxypyridin-2-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

(5-methoxypyrazin-2-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

(2-hydroxy-3-methoxyphenyl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

(2-methyloxazol-4-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

(4-(2-hydroxypropan-2-yl)phenyl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

(6-ethoxypyridin-2-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

(1H-benzo[d]imidazol-6-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

imidazo[1,2-a]pyrazin-2-yl(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

(4-hydroxy-7-methyl-1,8-naphthyridin-3-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

N-(4-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)pyridin-2-yl)acetamide;

N-(6-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)pyridin-2-yl)acetamide;

(4-((4-chlorophenyl)sulfonyl)piperidin-1-yl)(p-tolyl)methanone;

(4-((4-chlorophenyl)sulfonyl)piperidin-1-yl)(4-methoxyphenyl)methanone;

(4-chlorophenyl)(4-((4-chlorophenyl)sulfonyl)piperidin-1-yl)methanone;

(4-((4-chlorophenyl)sulfonyl)piperidin-1-yl)(1,5-naphthyridin-2-yl)methanone;

(4-((4-chlorophenyl)sulfonyl)piperidin-1-yl)(6-methoxy-1-methyl-1H-indol-2-yl)methanone;

quinolin-8-yl(4-((3-(trifluoromethyl)phenyl)sulfonyl)piperidin-1-yl)methanone;

quinolin-8-yl(4-tosylpiperidin-1-yl)methanone;

(4-((4-chlorophenyl)sulfonyl)piperidin-1-yl)(isoquinolin-3-yl)methanone;

4-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)benzamide;

3-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)benzamide;

3-(4-(4-chlorophenoxy)piperidine-1-carbonyl)benzamide;

3-(4-(4-chlorophenoxy)piperidine-1-carbonyl)-N-methylbenzamide;

4-(4-(4-chlorophenoxy)piperidine-1-carbonyl)-N-methylbenzamide;

(4-hydroxyquinolin-2-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

(3-hydroxyquinoxalin-2-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

(6-(hydroxymethyl)pyridin-2-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

(1-(2-hydroxyethyl)-2-methyl-1H-benzo[d]imidazol-5-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

(2-hydroxy-6-methylpyridin-4-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

1-methyl-4-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)pyridin-2(1H)-one;

(2-hydroxy-6-methylpyridin-3-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

3-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)quinolin-2(1H)-one;

(1H-1,2,4-triazol-3-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

2-cyclopropyl-6-methyl-5-(4-((3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)pyrimidin-4(1H)-one;

5,6-dimethyl-3-(4-((3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)pyridin-2(1H)-one;

(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)(1,3,6-trimethyl-1H-pyrazolo[3,4-b]pyridin-4-yl)methanone;

4-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)-1H-benzo[d]imidazol-2(3H)-one;

(4-(4-chloro-2-methoxyphenoxy)piperidin-1-yl)(quinolin-8-yl)methanone;

1-(5-chloro-2-((1-(quinoline-8-carbonyl)piperidin-4-yl)oxy)phenyl)ethanone;

5-chloro-2-((1-(quinoline-8-carbonyl)piperidin-4-yl)oxy)benzonitrile;

(4-((4-chlorophenyl)sulfonyl)piperidin-1-yl)(quinoxalin-2-yl)methanone;

(4-((4-chlorophenyl)sulfonyl)piperidin-1-yl)(6-methoxyquinolin-2-yl)methanone;

(4-((4-chlorophenyl)sulfonyl)piperidin-1-yl)(4-methyl-2-phenylpyrimidin-5-yl)methanone;

(4-((4-chlorophenyl)sulfonyl)piperidin-1-yl)(6-(pyrrolidin-1-yl)pyridin-2-yl)methanone;

(5-(tert-butyl)isoxazol-3-yl)(4-((4-chlorophenyl)sulfonyl)piperidin-1-yl)methanone;

(4-((4-chlorophenyl)sulfonyl)piperidin-1-yl)(6-(2,2,2-trifluoroethoxyl)pyridin-3-yl)methanone;

(4-((4-chlorophenyl)sulfonyl)piperidin-1-yl)(1-methyl-1H-indol-5-yl)methanone;

(4-((4-chlorophenyl)sulfonyl)piperidin-1-yl)(1-methyl-1H-indol-2-yl)methanone;

(4-(3-fluorophenoxyl)piperidin-1-yl)(4-fluorophenyl)methanone;

(4-((4-chlorophenyl)sulfonyl)piperidin-1-yl)(1-methyl-1H-indol-6-yl)methanone;

3-(4-(3-(trifluoromethyl)phenoxy)piperidine-1-carbonyl)benzamide;

4-(4-(3-(trifluoromethyl)phenoxy)piperidine-1-carbonyl)benzamide;

4-(4-(3-(trifluoromethyl)phenoxy)piperidine-1-carbonyl)picolinamide;

(4-((4-chlorophenyl)sulfonyl)piperidin-1-yl)(2-methoxyquinolin-4-yl)methanone;

(4-((4-chlorophenyl)sulfonyl)piperidin-1-yl)(6-phenoxypyridin-3-yl)methanone;

3-(4-((4-chlorophenyl)sulfonyl)piperidine-1-carbonyl)quinolin-2(1H)-one;

3-(4-((4-chlorophenyl)sulfonyl)piperidine-1-carbonyl)-1-methylquinolin-2(1H)-one;

(4-(4-fluorophenoxyl)piperidin-1-yl)(5-methyl-1-phenyl-1H-pyrazol-4-yl)methanone;

4-(4-(4-chlorophenoxy)piperidine-1-carbonyl)-N-(2-methoxyethyl)-N-methylbenzamide;

4-(4-(4-chlorophenoxy)piperidine-1-carbonyl)-N-(2-methoxyethyl)benzamide;

4-(4-(4-chlorophenoxy)piperidine-1-carbonyl)-N-(1-((1-hydroxycyclohexyl)methyl)piperidin-4-yl)benzamide;

(S)-4-(4-(4-chlorophenoxyl)piperidine-1-carbonyl)-N-(2-hydroxy-1-phenylethyl)benzamide;

(S)-4-(4-(4-chlorophenoxyl)piperidine-1-carbonyl)-N-(2-hydroxy-2-phenylethyl)benzamide;

(S)-4-(4-(4-chlorophenoxyl)piperidine-1-carbonyl)-N-(1-hydroxy-3-phenylpropan-2-yl)benzamide;

(S)—

N-(1-amino-1-oxo-3-phenylpropan-2-yl)-4-(4-(4-chlorophenoxy)piperidine-1-carbonyl)benzamide;

(4-((4-chlorophenyl)sulfonyl)piperidin-1-yl)(1-methyl-1H-indol-4-yl)methanone;

4-(4-((4-chlorophenyl)thio)piperidine-1-carbonyl)picolinamide;

6-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)picolinamide;

4-(4-(4-chlorophenoxy)piperidine-1-carbonyl)-N-(2-oxo-2-phenyl ethyl)benzamide;

(2-(methylsulfonyl)phenyl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

(3-(methylsulfonyl)phenyl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

(4-((4-chlorophenyl)sulfonyl)piperidin-1-yl)(5-fluoro-1-methyl-1H-indol-2-yl)methanone;

(4-((4-chlorophenyl)sulfonyl)piperidin-1-yl)(6-fluoro-1-methyl-1H-indol-2-yl)methanone;

(4-(3-ethoxyphenoxyl)piperidin-1-yl)(quinolin-8-yl)methanone;

(4-((4-chlorophenyl)sulfonyl)piperidin-1-yl)(3-(2-methylthiazol-4-yl)phenyl)methanone;

N-methyl-3-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)benzamide;

3-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)benzenesulfonamide;

4-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)benzenesulfonamide;

(4-(4-fluorophenoxyl)piperidin-1-yl)(1,5-naphthyridin-2-yl)methanone;

(4-(4-fluorophenoxyl)piperidin-1-yl)(quinolin-2-yl)methanone;

(4-(3-fluorophenoxyl)piperidin-1-yl)(4-methoxyquinolin-2-yl)methanone;

(1H-benzo[d][1,2,3]triazol-7-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

2-(2-(4-(4-chlorophenoxy)piperidine-1-carbonyl)phenoxy)acetamide;

2-(4-(4-(4-chlorophenoxy)piperidine-1-carbonyl)phenoxy)acetamide;

2-(2-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)phenoxy)acetamide;

2-(3-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)phenoxy)acetamide;

2-(4-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)phenoxy)acetamide;

(8-hydroxyquinolin-2-yl)(4-((3-(trifluoromethoxy)phenyl)sulfonyl)piperidin-1-yl)methanone;

quinolin-8-yl(4-((3-(trifluoromethoxy)phenyl)sulfonyl)piperidin-1-yl)methanone;

quinolin-2-yl(4-((3-(trifluoromethoxy)phenyl)sulfonyl)piperidin-1-yl)methanone;

(4-((4-chlorophenyl)sulfonyl)piperidin-1-yl)(5-phenylisoxazol-3-yl)methanone;

(6-methoxyquinolin-2-yl)(4-((3-(trifluoromethoxy)phenyl)sulfonyl)piperidin-1-yl)methanone;

(5-methyl-2-phenyl-2H-1,2,3-triazol-4-yl)(4-((3-(trifluoromethoxy)phenyl)sulfonyl)piperidin-1-yl)methanone;

(5-fluoro-1-methyl-1H-indol-2-yl)(4-((3-(trifluoromethoxy)phenyl)sulfonyl)piperidin-1-yl)methanone;

(6-fluoro-1-methyl-1H-indol-2-yl)(4-((3-(trifluoromethoxy)phenyl)sulfonyl)piperidin-1-yl)methanone;

(4-hydroxyquinolin-8-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

(1,8-naphthyridin-4-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

(1,6-naphthyridin-8-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

[1,2,4]triazolo[1,5-a]pyrimidin-2-yl(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

(5-methyl-1H-pyrazol-3-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

2-chloro-5-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)benzenesulfonamide;

(S)-3-(4-(4-chlorophenoxyl)piperidine-1-carbonyl)-N-(2-hydroxy-2-phenylethyl)benzamide;

(S)-3-(4-(4-chlorophenoxyl)piperidine-1-carbonyl)-N-(2-hydroxy-1-phenylethyl)benzamide;

(S)-3-(4-(4-chlorophenoxyl)piperidine-1-carbonyl)-N-(1-hydroxy-3-phenylpropan-2-yl)benzamide;

(S)—

N-(1-amino-1-oxo-3-phenylpropan-2-yl)-3-(4-(4-chlorophenoxy)piperidine-1-carbonyl)benzamide;

(4-((3-ethoxyphenyl)sulfonyl)piperidin-1-yl)(8-hydroxyquinolin-2-yl)methanone;

(4-((4-chlorophenyl)sulfonyl)piperidin-1-yl)(4-methyl-2-phenylthiazol-5-yl)methanone;

(4-((4-chlorophenyl)sulfonyl)piperidin-1-yl)(2-phenylthiazol-4-yl)methanone;

(4-chloro-2-(methylsulfonyl)phenyl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

(5-fluoro-2-(methylsulfonyl)phenyl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

N,N-dimethyl-4-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)benzenesulfonamide;

N-(2-(4-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)phenoxy)ethyl)acetamide;

(2-phenyl-1H-imidazol-5-yl)(4-((3-(trifluoromethoxy)phenyl)sulfonyl)piperidin-1-yl)methanone;

(3-(2-methylthiazol-4-yl)phenyl)(4-((3-(trifluoromethoxy)phenyl)sulfonyl)piperidin-1-yl)methanone;

N-(4-(4-(3-ethoxyphenoxyl)piperidine-1-carbonyl)pyridin-2-yl)acetamide;

(4-(3-ethoxyphenoxyl)piperidin-1-yl)(2-(methylsulfonyl)phenyl)methanone;

3-(4-(3-ethoxyphenoxy)piperidine-1-carbonyl)benzenesulfonamide;

N-(6-(4-(3-ethoxyphenoxyl)piperidine-1-carbonyl)pyridin-2-yl)acetamide;

(4-(3-ethoxyphenoxyl)piperidin-1-yl)(2-methyl-2H-indazol-3-yl)methanone;

(4-(3-ethoxyphenoxyl)piperidin-1-yl)(1,5-naphthyridin-2-yl)methanone;

(8-hydroxyquinolin-2-yl)(4-((4-(trifluoromethoxy)phenyl)sulfonyl)piperidin-1-yl)methanone;

quinolin-8-yl(4-((4-(trifluoromethoxy)phenyl)sulfonyl)piperidin-1-yl)methanone;

quinolin-2-yl(4-((4-(trifluoromethoxy)phenyl)sulfonyl)piperidin-1-yl)methanone;

N-(3-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)phenyl)methanesulfonamide;

(2-(ethylsulfonyl)phenyl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

(3-fluoro-4-(methylsulfonyl)phenyl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

ethyl (4-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)pyridin-2-yl)carbamate;

2-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)thiazole-4-carboxamide;

N,N-dimethyl-2-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)benzenesulfonamide;

(4-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)phenyl)methanesulfonamide;

4-methoxy-3-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)benzenesulfonamide;

2-((2-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)pyridin-3-yl)oxy)acetamide;

(4-(aminomethyl)pyridin-2-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

N-((2-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)pyridin-4-yl)methyl)methanesulfonamide;

ethyl ((2-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)pyridin-4-yl)methyl)carbamate;

N-(2-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)benzyl)acetamide;

N-(2-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)benzyl)methanesulfonamide;

ethyl 2-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)benzylcarbamate;

(2-(methylsulfonyl)phenyl)(4-(3-(2,2,2-trifluoroethoxy)phenoxy)piperidin-1-yl)methanone;

N-(4-(4-(3-(2,2,2-trifluoroethoxy)phenoxy)piperidine-1-carbonyl)pyridin-2-yl)acetamide;

4-(4-(3-(2,2,2-trifluoroethoxy)phenoxy)piperidine-1-carbonyl)picolinamide;

3-(4-(3-(2,2,2-trifluoroethoxy)phenoxy)piperidine-1-carbonyl)benzamide;

3-(4-(3-(2,2,2-trifluoroethoxy)phenoxy)piperidine-1-carbonyl)benzenesulfonamide;

2-(2-(4-(3-(2,2,2-trifluoroethoxy)phenoxy)piperidine-1-carbonyl)phenoxy)acetamide;

quinolin-8-yl(4-(3-(2,2,2-trifluoroethoxyl)phenoxy)piperidin-1-yl)methanone;

(1,5-naphthyridin-2-yl)(4-(3-(2,2,2-trifluoroethoxyl)phenoxy)piperidin-1-yl)methanone;

(2-methyl-2H-indazol-3-yl)(4-(3-(2,2,2-trifluoroethoxyl)phenoxy)piperidin-1-yl)methanone;

(1,3-dimethyl-1H-pyrazol-5-yl)(4-(3-(2,2,2-trifluoroethoxy)phenoxy)piperidin-1-yl)methanone;

N-(6-(4-(3-(2,2,2-trifluoroethoxy)phenoxy)piperidine-1-carbonyl)pyridin-2-yl)acetamide;

4-(4-(3-(2,2,2-trifluoroethoxy)phenoxy)piperidine-1-carbonyl)benzamide;

(3,5-dimethylisoxazol-4-yl)(4-(3-(2,2,2-trifluoroethoxy)phenoxy)piperidin-1-yl)methanone;

(3-(methylsulfonyl)phenyl)(4-(3-(2,2,2-trifluoroethoxy)phenoxy)piperidin-1-yl)methanone;

(1,6-naphthyridin-8-yl)(4-(3-(2,2,2-trifluoroethoxyl)phenoxy)piperidin-1-yl)methanone;

(3-methyl-1H-pyrazol-5-yl)(4-(3-(2,2,2-trifluoroethoxyl)phenoxy)piperidin-1-yl)methanone;

2-(3-(4-(3-(2,2,2-trifluoroethoxy)phenoxy)piperidine-1-carbonyl)phenoxy)acetamide;

(5-((tetrahydro-2H-pyran-4-yl)oxy)pyridin-3-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

1-(3-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)phenyl)urea;

1-(4-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)phenyl)urea;

(1H-1,2,4-triazol-3-yl)(4-(3-(2,2,2-trifluoroethoxyl)phenoxy)piperidin-1-yl)methanone;

(4-(3-ethoxyphenoxyl)piperidin-1-yl)(3-(methylsulfonyl)phenyl)methanone;

(4-(3-ethoxyphenoxyl)piperidin-1-yl)(3-methyl-1H-pyrazol-5-yl)methanone;

N,N-dimethyl-3-(4-((3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)benzenesulfonamide;

N-(2-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)phenyl)methanesulfonamide;

(6-aminopyridin-2-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

2-(methyl(3-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)benzyl)amino)acetamide;

2-(methyl(4-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)benzyl)amino)acetamide;

N,N-dimethyl-2-(2-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)phenoxy)acetamide;

(1,3-dimethyl-1H-pyrazol-5-yl)(4-(3-(trifluoromethyl)phenoxy)piperidin-1-yl)methanone;

(2-(methylsulfonyl)phenyl)(4-(3-(trifluoromethyl)phenoxy)piperidin-1-yl)methanone;

N-(6-(4-(3-(trifluoromethyl)phenoxy)piperidine-1-carbonyl)pyridin-2-yl)acetamide;

3-(4-(3-(trifluoromethyl)phenoxy)piperidine-1-carbonyl)benzenesulfonamide;

(3,5-dimethylisoxazol-4-yl)(4-(3-(trifluoromethyl)phenoxy)piperidin-1-yl)methanone;

(1,6-naphthyridin-8-yl)(4-(3-(trifluoromethyl)phenoxy)piperidin-1-yl)methanone;

(3-methyl-1H-pyrazol-5-yl)(4-(3-(trifluoromethyl)phenoxy)piperidin-1-yl)methanone;

2-(2-(4-(3-(trifluoromethyl)phenoxy)piperidine-1-carbonyl)phenoxy)acetamide;

2-(4-(4-(3-(trifluoromethyl)phenoxy)piperidine-1-carbonyl)phenoxy)acetamide;

2-(3-(4-(3-(trifluoromethyl)phenoxy)piperidine-1-carbonyl)phenoxy)acetamide;

(1H-1,2,4-triazol-3-yl)(4-(3-(trifluoromethyl)phenoxy)piperidin-1-yl)methanone;

N-(2-(2-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)phenoxy)ethyl)acetamide;

N-(2-(2-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)phenoxy)ethyl)methanesulfonamide;

ethyl (2-(2-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)phenoxy)ethyl)carbamate;

N-(2-(2-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)phenoxy)ethyl)cyclopropane-1,1-dicarboxamide;

(3-(2-aminoethoxy)phenyl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

N-(2-(3-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)phenoxy)ethyl)acetamide;

N-(2-(3-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)phenoxy)ethyl)methanesulfonamide;

ethyl (2-(3-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)phenoxy)ethyl)carbamate;

N-(2-(3-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)phenoxy)ethyl)cyclopropane-1,1-dicarboxamide;

N-(3-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)pyridin-2-yl)acetamide;

N-(1-methyl-5-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)-1H-pyrazol-3-yl)acetamide;

(2-(ethylsulfonyl)phenyl)(4-(3-(trifluoromethyl)phenoxy)piperidin-1-yl)methanone;

(4-(3-ethoxyphenoxyl)piperidin-1-yl)(2-(ethylsulfonyl)phenyl)methanone;

(2-(ethylsulfonyl)phenyl)(4-(3-(2,2,2-trifluoroethoxy)phenoxy)piperidin-1-yl)methanone;

N-(2-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)pyridin-3-yl)acetamide;

2-(4-(4-(3-chlorophenoxy)piperidine-1-carbonyl)phenoxy)acetamide;

2-(2-(4-((4-chlorophenyl)thio)piperidine-1-carbonyl)phenoxy)acetamide;

2-(3-(4-((4-chlorophenyl)thio)piperidine-1-carbonyl)phenoxy)acetamide;

(4-((4-chlorophenyl)thio)piperidin-1-yl)(2-(methylsulfonyl)phenyl)methanone;

2-(methyl(2-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)benzyl)amino)acetamide;

1-morpholino-2-(2-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)phenoxy)ethanone;

1-(piperidin-1-yl)-2-(2-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)phenoxy)ethanone;

(2-(2-methoxyethoxyl)phenyl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

(3-(methylsulfonyl)phenyl)(4-(3-(trifluoromethyl)phenoxy)piperidin-1-yl)methanone;

(4-(3-chlorophenoxyl)piperidin-1-yl)(3-(methylsulfonyl)phenyl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(3-(methylsulfonyl)phenyl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2-(ethylsulfonyl)phenyl)methanone;

N,N-dimethyl-3-(4-(3-(trifluoromethyl)phenoxy)piperidine-1-carbonyl)benzenesulfonamide;

3-(4-(4-chlorophenoxy)piperidine-1-carbonyl)-N,N-dimethylbenzenesulfonamide;

N,N-dimethyl-3-(4-(3-(2,2,2-trifluoroethoxy)phenoxy)piperidine-1-carbonyl)benzenesulfonamide;

N,N-dimethyl-2-(4-(3-(trifluoromethyl)phenoxy)piperidine-1-carbonyl)benzenesulfonamide;

2-(4-(4-chlorophenoxy)piperidine-1-carbonyl)-N,N-dimethylbenzenesulfonamide;

N,N-dimethyl-2-(4-(3-(2,2,2-trifluoroethoxy)phenoxy)piperidine-1-carbonyl)benzenesulfonamide;

(4-(3-(2-methoxyethoxyl)phenoxy)piperidin-1-yl)(quinolin-8-yl)methanone;

(4-(3-(2-methoxyethoxyl)phenoxy)piperidin-1-yl)(quinolin-2-yl)methanone;

(4-(3-(2-methoxyethoxyl)phenoxy)piperidin-1-yl)(2-methyl-2H-indazol-3-yl)methanone;

2-((2-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)phenyl)thio)acetamide;

2-((2-(4-(4-chlorophenoxyl)piperidine-1-carbonyl)phenyl)thio)acetamide;

4-(4-(3-(2,2,2-trifluoroethoxy)phenoxy)piperidine-1-carbonyl)-1H-benzo[d]imidazol-2(3H)-one;

(4-(3-ethoxyphenoxyl)piperidin-1-yl)(1-methyl-1H-benzo[d]imidazol-2-yl)methanone;

(4-(3-fluorophenoxyl)piperidin-1-yl)(1-methyl-1H-benzo[d]imidazol-2-yl)methanone;

(1H-pyrrolo[2,3-b]pyridin-2-yl)(4-(3-(2,2,2-trifluoroethoxy)phenoxy)piperidin-1-yl)methanone;

(4-(3-ethoxyphenoxyl)piperidin-1-yl)(1H-pyrrolo[2,3-b]pyridin-2-yl)methanone;

(1H-pyrrolo[2,3-b]pyridin-2-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

(4-(3-ethoxyphenoxyl)piperidin-1-yl)(1-methyl-1H-pyrazolo[3,4-b]pyridin-3-yl)methanone;

(4-(3-ethoxyphenoxyl)piperidin-1-yl)(1H-pyrrolo[2,3-b]pyridin-3-yl)methanone;

(4-(3-ethoxyphenoxyl)piperidin-1-yl)(pyrazolo[1,5-a]pyrimidin-3-yl)methanone;

(1,3-dimethyl-1H-thieno[2,3-c]pyrazol-5-yl)(4-(3-ethoxyphenoxyl)piperidin-1-yl)methanone;

(4-(3-fluorophenoxyl)piperidin-1-yl)(4-methyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)methanone;

(3,5-dimethyl-1H-pyrazol-4-yl)(4-(3-(2,2,2-trifluoroethoxy)phenoxy)piperidin-1-yl)methanone;

N-(2-hydroxyethyl)-N-methyl-2-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)benzenesulfonamide;

N-(2-methoxyethyl)-N-methyl-2-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)benzenesulfonamide;

(2-(morpholinosulfonyl)phenyl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

2-(N-methyl-2-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)phenylsulfonamido)acetamide;

N-methyl-3-(4-(3-(2,2,2-trifluoroethoxy)phenoxy)piperidine-1-carbonyl)benzenesulfonamide;

3-(4-(3-ethoxyphenoxy)piperidine-1-carbonyl)-N-methylbenzenesulfonamide;

N-methyl-3-(4-((3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)benzenesulfonamide;

(1,5-naphthyridin-2-yl)(4-(3-(trifluoromethyl)phenoxy)piperidin-1-yl)methanone;

3-(4-((4-chlorophenyl)thio)piperidine-1-carbonyl)benzenesulfonamide;

(4-((4-chlorophenyl)thio)piperidin-1-yl)(1,5-naphthyridin-2-yl)methanone;

N-(6-(4-((4-chlorophenyl)thio)piperidine-1-carbonyl)pyridin-2-yl)acetamide;

(4-((4-chlorophenyl)thio)piperidin-1-yl)(1,6-naphthyridin-8-yl)methanone;

2-(4-(4-(3,4-difluorophenoxy)piperidine-1-carbonyl)phenoxy)acetamide;

(4-(3,4-difluorophenoxyl)piperidin-1-yl)(1,5-naphthyridin-2-yl)methanone;

2-(4-(4-(2,4-difluorophenoxy)piperidine-1-carbonyl)phenoxy)acetamide;

N-(4-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)pyridin-2-yl)pivalamide;

(2-(1H-imidazol-1-yl)pyridin-4-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

N-(4-(4-(3-ethoxyphenoxyl)piperidine-1-carbonyl)pyridin-2-yl)pivalamide;

1-(3-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)phenyl)pyrrolidin-2-one;

1-(3-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)phenyl)imidazolidin-2-one; and

(5-amino-1H-pyrazol-3-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

or a pharmaceutically acceptable salt thereof.

4. A compound which is selected from:

(4-(4-chlorophenoxyl)piperidin-1-yl)(quinoxalin-6-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(quinolin-8-yl)methanone;

(4-(1H-1,2,4-triazol-1-yl)phenyl)(4-(4-chlorophenoxyl)piperidin-1-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(3,5-dimethylisoxazol-4-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2-methyl-2H-indazol-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(6-methylpyridin-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(6-methoxypyridin-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(3-methylpyridin-2-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2,4-dimethylthiazol-5-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(4,5,6,7-tetrahydro-1H-indazol-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(6-methoxypyridin-2-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2-methyl-4,5,6,7-tetrahydro-2H-indazol-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1,5-naphthyridin-2-yl)methanone;

4-(4-(4-chlorophenoxy)piperidine-1-carbonyl)benzamide;

(4-(4-chlorophenoxyl)piperidin-1-yl)(4-(2-hydroxypropan-2-yl)phenyl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(quinolin-5-yl)methanone;

(4-(4-fluorophenoxyl)piperidin-1-yl)(2-methyl-2H-indazol-3-yl)methanone;

(4-phenoxypiperidin-1-yl)(quinolin-8-yl)methanone;

(4-(4-fluorophenoxyl)piperidin-1-yl)(quinolin-8-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(phenyl)methanone;

(1H-benzo[d]imidazol-5-yl)(4-(4-chlorophenoxyl)piperidin-1-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1,3-dimethyl-1H-pyrazol-5-yl)methanone;

(4-(3-methoxyphenoxyl)piperidin-1-yl)(quinolin-8-yl)methanone;

(4-(3-fluorophenoxyl)piperidin-1-yl)(quinolin-8-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2-methylthiazol-5-yl)methanone;

1-(3-((1-(quinoline-8-carbonyl)piperidin-4-yl)oxy)phenyl)ethanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(3-methylisoxazol-5-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1-isopropyl-1H-pyrazol-4-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(3-isopropyl-1-methyl-1H-pyrazol-5-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(3-ethyl-1-methyl-1H-pyrazol-5-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(imidazo[1,2-a]pyrazin-2-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(4-methyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(pyrazolo[1,5-a]pyridin-7-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1-methyl-1H-imidazol-2-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1-methyl-1H-imidazol-4-yl)methanone;

(4-chloro-5-methyl-1H-pyrazol-3-yl)(4-(4-chlorophenoxy)piperidin-1-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(4-methyl-4H-furo[3,2-b]pyrrol-5-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(pyrazolo[1,5-a]pyrimidin-3-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2-(pyrrolidin-1-yl)pyrimidin-5-yl)methanone;

(1H-benzo[d][1,2,3]triazol-4-yl)(4-(4-chlorophenoxyl)piperidin-1-yl)methanone;

3-(4-(4-chlorophenoxy)piperidine-1-carbonyl)-1,6-dimethylpyridin-2(1H)-one;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(4-(2-hydroxyethoxyl)phenyl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2-hydroxy-4-methoxyphenyl)methanone;

2-(3-(4-(4-chlorophenoxy)piperidine-1-carbonyl)-1H-indol-1-yl)-N,N-dimethylacetamide;

(4-(4-chlorophenoxyl)piperidin-1-yl)(3-fluoro-4-hydroxyphenyl)methanone;

2-chloro-5-(4-(4-chlorophenoxyl)piperidine-1-carbonyl)benzenesulfonamide;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2-hydroxy-6-methoxyphenyl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2-fluoro-4-hydroxyphenyl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(4-fluoro-3-hydroxyphenyl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2-hydroxy-3-methoxyphenyl)methanone;

N-(3-(4-(4-chlorophenoxy)piperidine-1-carbonyl)phenyl)acetamide;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1-((4-hydroxytetrahydro-2H-pyran-4-yl)methyl)-1H-indol-5-yl)methanone;

N-(6-(4-(4-chlorophenoxy)piperidine-1-carbonyl)pyridin-2-yl)acetamide;

N-(4-(4-(4-chlorophenoxy)piperidine-1-carbonyl)pyridin-2-yl)acetamide;

(4-(4-chlorophenoxyl)piperidin-1-yl)(1,6-naphthyridin-5-yl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(3-hydroxyphenyl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2-fluoro-3-hydroxyphenyl)methanone;

(3-(tert-butyl)-1-methyl-1H-pyrazol-5-yl)(4-(4-fluorophenoxyl)piperidin-1-yl)methanone;

(4-fluoro-3-methoxyphenyl)(4-(4-fluorophenoxyl)piperidin-1-yl)methanone;

(4-((4-chlorophenyl)sulfonyl)piperidin-1-yl)(2-methyl-2H-indazol-3-yl)methanone;

(4-(4-fluorophenoxyl)piperidin-1-yl)(1-methyl-1H-indazol-3-yl)methanone;

(4-(4-fluorophenoxyl)piperidin-1-yl)(4-methoxyquinolin-2-yl)methanone;

(4-(4-fluorophenoxyl)piperidin-1-yl)(isoquinolin-1-yl)methanone;

(5-aminopyridin-2-yl)(4-(4-chlorophenoxyl)piperidin-1-yl)methanone;

(1,3-dimethyl-1H-pyrazol-5-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

(3,5-dimethylisoxazol-4-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

(3-methylpyridin-2-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

4-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)picolinamide;

(1-methyl-1H-imidazol-4-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

(2-hydroxy-6-methoxyphenyl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

(2,4-dimethylthiazol-5-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

(2-methyl-2H-indazol-3-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

1,6-dimethyl-3-(4-((3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)pyridin-2(1H)-one;

benzo[d]thiazol-6-yl(4-(4-fluorophenoxyl)piperidin-1-yl)methanone;

(4-(4-fluorophenoxyl)piperidin-1-yl)(1-methyl-1H-benzo[d]imidazol-2-yl)methanone;

(2-methyloxazol-4-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

N-(4-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)pyridin-2-yl)acetamide;

N-(6-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)pyridin-2-yl)acetamide;

3-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)benzamide;

(6-(hydroxymethyl)pyridin-2-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

5,6-dimethyl-3-(4-((3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)pyridin-2(1H)-one;

4-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)-1H-benzo[d]imidazol-2(3H)-one;

(4-(4-chloro-2-methoxyphenoxy)piperidin-1-yl)(quinolin-8-yl)methanone;

3-(4-(3-(trifluoromethyl)phenoxy)piperidine-1-carbonyl)benzamide;

4-(4-(3-(trifluoromethyl)phenoxy)piperidine-1-carbonyl)picolinamide;

(4-(4-fluorophenoxyl)piperidin-1-yl)(5-methyl-1-phenyl-1H-pyrazol-4-yl)methanone;

4-(4-(4-chlorophenoxyl)piperidine-1-carbonyl)-N-(2-methoxyethyl)-N-methylbenzamide;

(S)-4-(4-(4-chlorophenoxyl)piperidine-1-carbonyl)-N-(2-hydroxy-2-phenylethyl)benzamide;

4-(4-((4-chlorophenyl)thio)piperidine-1-carbonyl)picolinamide;

6-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)picolinamide;

(2-(methylsulfonyl)phenyl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

(4-(3-ethoxyphenoxyl)piperidin-1-yl)(quinolin-8-yl)methanone;

N-methyl-3-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)benzamide;

3-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)benzenesulfonamide;

4-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)benzenesulfonamide;

(4-(4-fluorophenoxyl)piperidin-1-yl)(1,5-naphthyridin-2-yl)methanone;

(4-(4-fluorophenoxyl)piperidin-1-yl)(quinolin-2-yl)methanone;

(4-(3-fluorophenoxyl)piperidin-1-yl)(4-methoxyquinolin-2-yl)methanone;

(1H-benzo[d][1,2,3]triazol-7-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

2-(2-(4-(4-chlorophenoxy)piperidine-1-carbonyl)phenoxy)acetamide;

2-(2-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)phenoxy)acetamide;

(4-((4-chlorophenyl)sulfonyl)piperidin-1-yl)(5-phenylisoxazol-3-yl)methanone;

(4-hydroxyquinolin-8-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

(1,8-naphthyridin-4-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

(1,6-naphthyridin-8-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

[1,2,4]triazolo[1,5-a]pyrimidin-2-yl(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

(5-methyl-1H-pyrazol-3-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

2-chloro-5-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)benzenesulfonamide;

(S)-3-(4-(4-chlorophenoxyl)piperidine-1-carbonyl)-N-(2-hydroxy-2-phenylethyl)benzamide;

(S)—

N-(1-amino-1-oxo-3-phenylpropan-2-yl)-3-(4-(4-chlorophenoxy)piperidine-1-carbonyl)benzamide;

(4-((4-chlorophenyl)sulfonyl)piperidin-1-yl)(2-phenylthiazol-4-yl)methanone;

(5-fluoro-2-(methylsulfonyl)phenyl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

N,N-dimethyl-4-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)benzenesulfonamide;

N-(2-(4-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)phenoxy)ethyl)acetamide;

N-(4-(4-(3-ethoxyphenoxyl)piperidine-1-carbonyl)pyridin-2-yl)acetamide;

3-(4-(3-ethoxyphenoxy)piperidine-1-carbonyl)benzenesulfonamide;

N-(6-(4-(3-ethoxyphenoxyl)piperidine-1-carbonyl)pyridin-2-yl)acetamide;

(4-(3-ethoxyphenoxyl)piperidin-1-yl)(1,5-naphthyridin-2-yl)methanone;

quinolin-8-yl(4-((4-(trifluoromethoxy)phenyl)sulfonyl)piperidin-1-yl)methanone;

quinolin-2-yl(4-((4-(trifluoromethoxy)phenyl)sulfonyl)piperidin-1-yl)methanone;

(2-(ethylsulfonyl)phenyl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

2-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)thiazole-4-carboxamide;

(4-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)phenyl)methanesulfonamide;

4-methoxy-3-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)benzenesulfonamide;

2-((2-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)pyridin-3-yl)oxy)acetamide;

(4-(aminomethyl)pyridin-2-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

N-((2-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)pyridin-4-yl)methyl)methanesulfonamide;

ethyl ((2-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)pyridin-4-yl)methyl)carbamate;

N-(2-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)benzyl)acetamide;

N-(2-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)benzyl)methanesulfonamide;

(2-(methylsulfonyl)phenyl)(4-(3-(2,2,2-trifluoroethoxy)phenoxy)piperidin-1-yl)methanone;

N-(4-(4-(3-(2,2,2-trifluoroethoxy)phenoxy)piperidine-1-carbonyl)pyridin-2-yl)acetamide;

4-(4-(3-(2,2,2-trifluoroethoxy)phenoxy)piperidine-1-carbonyl)picolinamide;

3-(4-(3-(2,2,2-trifluoroethoxy)phenoxy)piperidine-1-carbonyl)benzamide;

2-(2-(4-(3-(2,2,2-trifluoroethoxy)phenoxy)piperidine-1-carbonyl)phenoxy)acetamide;

(1,5-naphthyridin-2-yl)(4-(3-(2,2,2-trifluoroethoxyl)phenoxy)piperidin-1-yl)methanone;

(2-methyl-2H-indazol-3-yl)(4-(3-(2,2,2-trifluoroethoxyl)phenoxy)piperidin-1-yl)methanone;

(1,3-dimethyl-1H-pyrazol-5-yl)(4-(3-(2,2,2-trifluoroethoxy)phenoxy)piperidin-1-yl)methanone;

N-(6-(4-(3-(2,2,2-trifluoroethoxy)phenoxy)piperidine-1-carbonyl)pyridin-2-yl)acetamide;

4-(4-(3-(2,2,2-trifluoroethoxy)phenoxy)piperidine-1-carbonyl)benzamide;

(3,5-dimethylisoxazol-4-yl)(4-(3-(2,2,2-trifluoroethoxy)phenoxy)piperidin-1-yl)methanone;

(3-(methylsulfonyl)phenyl)(4-(3-(2,2,2-trifluoroethoxy)phenoxy)piperidin-1-yl)methanone;

(1,6-naphthyridin-8-yl)(4-(3-(2,2,2-trifluoroethoxyl)phenoxy)piperidin-1-yl)methanone;

(3-methyl-1H-pyrazol-5-yl)(4-(3-(2,2,2-trifluoroethoxyl)phenoxy)piperidin-1-yl)methanone;

2-(3-(4-(3-(2,2,2-trifluoroethoxy)phenoxy)piperidine-1-carbonyl)phenoxy)acetamide;

1-(4-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)phenyl)urea;

(1H-1,2,4-triazol-3-yl)(4-(3-(2,2,2-trifluoroethoxyl)phenoxy)piperidin-1-yl)methanone;

(4-(3-ethoxyphenoxyl)piperidin-1-yl)(3-(methylsulfonyl)phenyl)methanone;

(4-(3-ethoxyphenoxyl)piperidin-1-yl)(3-methyl-1H-pyrazol-5-yl)methanone;

N,N-dimethyl-3-(4-((3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)benzenesulfonamide;

N-(2-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)phenyl)methanesulfonamide;

(6-aminopyridin-2-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

N,N-dimethyl-2-(2-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)phenoxy)acetamide;

(1,3-dimethyl-1H-pyrazol-5-yl)(4-(3-(trifluoromethyl)phenoxy)piperidin-1-yl)methanone;

(2-(methylsulfonyl)phenyl)(4-(3-(trifluoromethyl)phenoxy)piperidin-1-yl)methanone;

N-(6-(4-(3-(trifluoromethyl)phenoxy)piperidine-1-carbonyl)pyridin-2-yl)acetamide;

3-(4-(3-(trifluoromethyl)phenoxy)piperidine-1-carbonyl)benzenesulfonamide;

(3,5-dimethylisoxazol-4-yl)(4-(3-(trifluoromethyl)phenoxy)piperidin-1-yl)methanone;

(1,6-naphthyridin-8-yl)(4-(3-(trifluoromethyl)phenoxy)piperidin-1-yl)methanone;

(3-methyl-1H-pyrazol-5-yl)(4-(3-(trifluoromethyl)phenoxy)piperidin-1-yl)methanone;

2-(2-(4-(3-(trifluoromethyl)phenoxy)piperidine-1-carbonyl)phenoxy)acetamide;

2-(3-(4-(3-(trifluoromethyl)phenoxy)piperidine-1-carbonyl)phenoxy)acetamide;

(1H-1,2,4-triazol-3-yl)(4-(3-(trifluoromethyl)phenoxy)piperidin-1-yl)methanone;

N-(2-(2-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)phenoxy)ethyl)methanesulfonamide;

N-(2-(2-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)phenoxy)ethyl)cyclopropane-1,1-dicarboxamide;

N-(2-(3-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)phenoxy)ethyl)methanesulfonamide;

N-(3-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)pyridin-2-yl)acetamide;

N-(1-methyl-5-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)-1H-pyrazol-3-yl)acetamide;

(2-(ethylsulfonyl)phenyl)(4-(3-(trifluoromethyl)phenoxy)piperidin-1-yl)methanone;

(2-(ethylsulfonyl)phenyl)(4-(3-(2,2,2-trifluoroethoxy)phenoxy)piperidin-1-yl)methanone;

N-(2-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)pyridin-3-yl)acetamide;

(3-(methylsulfonyl)phenyl)(4-(3-(trifluoromethyl)phenoxy)piperidin-1-yl)methanone;

(4-(3-chlorophenoxyl)piperidin-1-yl)(3-(methylsulfonyl)phenyl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(3-(methylsulfonyl)phenyl)methanone;

(4-(4-chlorophenoxyl)piperidin-1-yl)(2-(ethylsulfonyl)phenyl)methanone;

N,N-dimethyl-3-(4-(3-(trifluoromethyl)phenoxy)piperidine-1-carbonyl)benzenesulfonamide;

3-(4-(4-chlorophenoxyl)piperidine-1-carbonyl)-N,N-dimethylbenzenesulfonamide;

(4-(3-(2-methoxyethoxyl)phenoxy)piperidin-1-yl)(quinolin-8-yl)methanone;

(4-(3-(2-methoxyethoxyl)phenoxy)piperidin-1-yl)(quinolin-2-yl)methanone;

(4-(3-(2-methoxyethoxyl)phenoxy)piperidin-1-yl)(2-methyl-2H-indazol-3-yl)methanone;

2-((2-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)phenyl)thio)acetamide;

2-((2-(4-(4-chlorophenoxyl)piperidine-1-carbonyl)phenyl)thio)acetamide;

4-(4-(3-(2,2,2-trifluoroethoxyl)phenoxy)piperidine-1-carbonyl)-1H-benzo[d]imidazol-2(3H)-one;

(4-(3-ethoxyphenoxyl)piperidin-1-yl)(1-methyl-1H-benzo[d]imidazol-2-yl)methanone;

(4-(3-fluorophenoxyl)piperidin-1-yl)(1-methyl-1H-benzo[d]imidazol-2-yl)methanone;

(4-(3-ethoxyphenoxyl)piperidin-1-yl)(1-methyl-1H-pyrazolo[3,4-b]pyridin-3-yl)methanone;

(4-(3-ethoxyphenoxyl)piperidin-1-yl)(pyrazolo[1,5-a]pyrimidin-3-yl)methanone;

(4-(3-fluorophenoxyl)piperidin-1-yl)(4-methyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)methanone;

(3,5-dimethyl-1H-pyrazol-4-yl)(4-(3-(2,2,2-trifluoroethoxyl)phenoxy)piperidin-1-yl)methanone;

N-(2-hydroxyethyl)-N-methyl-2-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)benzenesulfonamide;

(2-(morpholinosulfonyl)phenyl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

2-(N-methyl-2-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)phenylsulfonamido)acetamide;

N-methyl-3-(4-(3-(2,2,2-trifluoroethoxyl)phenoxy)piperidine-1-carbonyl)benzenesulfonamide;

3-(4-(3-ethoxyphenoxyl)piperidine-1-carbonyl)-N-methylbenzenesulfonamide;

N-methyl-3-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)benzenesulfonamide;

(4-((4-chlorophenyl)thio)piperidin-1-yl)(1,5-naphthyridin-2-yl)methanone;

N-(6-(4-((4-chlorophenyl)thio)piperidine-1-carbonyl)pyridin-2-yl)acetamide;

2-(4-(4-(3,4-difluorophenoxy)piperidine-1-carbonyl)phenoxy)acetamide;

(4-(3,4-difluorophenoxyl)piperidin-1-yl)(1,5-naphthyridin-2-yl)methanone;

2-(4-(4-(2,4-difluorophenoxy)piperidine-1-carbonyl)phenoxy)acetamide;

N-(4-(4-(3-(trifluoromethoxy)phenoxy)piperidine-1-carbonyl)pyridin-2-yl)pivalamide; and

(5-amino-1H-pyrazol-3-yl)(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)methanone;

or a pharmaceutically acceptable salt thereof.