Inhibitors of influenza viruses replication

• US 9,051,319 B2
• Filed: 12/06/2013
• Issued: 06/09/2015
• Est. Priority Date: 08/01/2011
• Status: Active Grant

• Current Assignee: Vertex Pharmaceuticals Incorporated
• Original Assignee: Vertex Pharmaceuticals Incorporated
• Inventors: Charifson, Paul S., Clark, Michael P., Bandarage, Upul K., Bethiel, Randy S., Boyd, Michael J., Davies, Ioana, Deng, Hongbo, Duffy, John P., Farmer, Luc J., Gao, Huai, Gu, Wenxin, Kennedy, Joseph M., Ledford, Brian, Ledeboer, Mark W., Maltais, Francois, Perola, Emanuele, Wang, Tiansheng
• Primary Examiner(s): Harward, Soren
• Assistant Examiner(s): CALVILLO, Y JEANMARIE Z
• Application Number:
  US14/099,054
• Publication Number:
  US 20140094473A1
• Time in Patent Office: 550 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61K 31/215 of carboxylic acids
• CPC Class Codes: A61K 31/351 not condensed with another ring
• CPC Class Codes: A61K 31/444 containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
• CPC Class Codes: A61K 31/497 containing further heterocyclic rings
• CPC Class Codes: A61K 31/506 not condensed and containing further heterocyclic rings
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61P 31/16 for influenza or rhinoviruses
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C07D 471/04 Ortho-condensed systems
• CPC Class Codes: C07F 9/6561 containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Abstract

Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I), or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.

Claims

1. A compound of the formula

2. A pharmaceutical composition comprising the compound of claim 1 and a pharmaceutically acceptable carrier, adjuvant, or vehicle.