Crystalline tripeptide epoxy ketone protease inhibitors
First Claim
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1. A method for treating a cancer in a patient, the method comprising administering to the patient a pharmaceutical composition comprising a therapeutically effective amount of a crystalline compound having a structure of Formula (II):
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Abstract
The invention relates to crystalline tripeptide keto epoxide compounds, methods of their preparation, and related pharmaceutical compositions.
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Citations
14 Claims
- 1. A method for treating a cancer in a patient, the method comprising administering to the patient a pharmaceutical composition comprising a therapeutically effective amount of a crystalline compound having a structure of Formula (II):
- 5. A method for treating an autoimmune disease in a patient, the method comprising administering to the patient a pharmaceutical composition comprising a therapeutically effective amount of a crystalline compound having a structure of Formula (II):
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7. A method for treating graft-versus-host disease in a patient, the method comprising administering to the patient a pharmaceutical composition comprising a therapeutically effective amount of a crystalline compound having a structure of Formula (II):
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8. A method for treating a neurodegenerative disease in a patient, the method comprising administering to the patient a pharmaceutical composition comprising a therapeutically effective amount of a crystalline compound having a structure of Formula (II):
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9. A method for treating inflammation in a patient, the method comprising administering to the patient a pharmaceutical composition comprising a therapeutically effective amount of a crystalline compound having a structure of Formula (II):
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10. A method for treating a fibrotic-associated condition in a patient, the method comprising administering to the patient a pharmaceutical composition comprising a therapeutically effective amount of a crystalline compound having a structure of Formula (II):
- 11. A method for treating an ischemic-related condition in a patient, the method comprising administering to the patient a pharmaceutical composition comprising a therapeutically effective amount of a crystalline compound having a structure of Formula (II):
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13. A method for treating an infection in a patient, the method comprising administering to the patient a pharmaceutical composition comprising a therapeutically effective amount of a crystalline compound having a structure of Formula (II):
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14. A method for treating osteoporosis in a patient, the method comprising administering to the patient a pharmaceutical composition comprising a therapeutically effective amount of a crystalline compound having a structure of Formula (II):
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