Methods for analyte detection

• US 9,052,263 B2
• Filed: 05/31/2012
• Issued: 06/09/2015
• Est. Priority Date: 04/15/2009
• Status: Active Grant

• Current Assignee: GE Infrastructure Technology, LLC (GE Vernova, Inc.)
• Original Assignee: General Electric Company
• Inventors: Potyrailo, Radislav Alexandrovich, Pietrzykowski, Matthew Damian, Lee, Yongjae
• Primary Examiner(s): Tsai, Carol S
• Application Number:
  US13/484,674
• Publication Number:
  US 20120235690A1
• Time in Patent Office: 1,104 Days
• Field of Search: 702/19, 702/23, 702/24, 324/652
• US Class Current: 1/1
• CPC Class Codes: G01N 27/026 Dielectric impedance spectroscopy electrochemical impedance spectroscopy for measuring corrosion G01N17/02
• CPC Class Codes: G01N 27/028 Circuits therefor measuring impedance per se G01R27/02

Abstract

A method is provided for selectively detecting the presence and concentration of at least four analytes in a mixture. In certain embodiments, the method comprises contacting a single sensor with the mixture of analytes, wherein the sensor comprises at least one resonant sensor circuit comprising a sensing material that comprises at least two material properties that change in the presence of four or more analytes in their mixtures, and generating a multivariate sensor response pattern. The methods disclosed herein further optionally comprise performing analyte classification and analyte quantitation. Methods for selectively detecting the concentration of at least one analyte in a mixture further comprising at least one interference are also described in the instant application.

Claims

1. A method for selective detection of at least two analytes with one wireless, multivariate, battery-free sensor, the method comprises the steps of:

contacting at least two analytes with a sensor circuit, wherein the sensor circuit comprises at least one integrated circuit chip that is configured to accept inputs from at least two sensors, where the sensors are positioned in proximity to the chip or are integrated into the chip;

detecting more than one analyte using at least two inputs into an integrated circuit chip of the sensor circuit where the inputs into the integrated circuit chip are from the same or from different sensing materials;

determining a multivariate response pattern of the sensor system upon sensor exposure to different analytes by performing a multivariate analysis of the response of at least two sensors; and

identifying the analytes and concentrations of at least two analytes from this pattern, wherein one of the analytes is an analyte of interest to an end-user and the second analyte is an interference or another analyte of interest to the end-user.

2. The method of claim 1, wherein the sensor is a sensing node and is a part of the sensor network.