Chain-extended polysiloxane crosslinkers with dangling hydrophilic polymer chains
First Claim
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1. A soluble amphiphilic prepolymer, which is obtained by:
- first polymerizing a polymerizable composition including(1) at least one chain-extended polysiloxane crosslinker,(2) at least one hydrophilic vinylic monomer,(3) a chain transfer agent with or without a first reactive functional group other than a thiol group and/or a vinylic monomer having a second reactive functional group other than an ethylenically unsaturated group,(4) optionally a hydrophobic vinylic monomer, and(5) optionally a polymerizable UV-absorbing agent, to form an intermediary copolymer; and
then ethylenically functionalizing the intermediary copolymer with an ethylenically functionalizing vinylic monomer having a third reactive functional group capable of reacting with the first or second reactive functional group to form a linkage in a coupling reaction in the presence or absence of a coupling agent to form the prepolymer, wherein the first, second and third reactive functional groups independent of each other are selected from the group consisting of amino group, hydroxyl group, carboxyl group, acid halide group, azlactone group, isocyanate group, epoxy group, aziridine group, and combination thereofwherein the linear chain-extended polysiloxane crosslinker comprises (a) two terminal ethylenically unsaturated groups, (b) at least two polysiloxane segments, and (c) at least one dangling hydrophilic polymer chain covalently attached to a divalent organic radical separating said at least two polysiloxane segments, wherein the linear chain extended polysiloxane crosslinker is as set forth by formula (I)
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Abstract
The invention provide a class of linear chain-extended polysiloxane crosslinkers which comprises two terminal ethylenically unsaturated groups, at least two polysiloxane segments, and dangling hydrophilic polymer chains each covalently attached to a divalent organic radical separating each pair of adjacent polysiloxane segments. The present invention is also related to a polymer comprising crosslinking units derived from chain-extended polysiloxane crosslinker of the invention and to ophthalmic lenses comprising such a polymer.
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Citations
5 Claims
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1. A soluble amphiphilic prepolymer, which is obtained by:
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first polymerizing a polymerizable composition including (1) at least one chain-extended polysiloxane crosslinker, (2) at least one hydrophilic vinylic monomer, (3) a chain transfer agent with or without a first reactive functional group other than a thiol group and/or a vinylic monomer having a second reactive functional group other than an ethylenically unsaturated group, (4) optionally a hydrophobic vinylic monomer, and (5) optionally a polymerizable UV-absorbing agent, to form an intermediary copolymer; and then ethylenically functionalizing the intermediary copolymer with an ethylenically functionalizing vinylic monomer having a third reactive functional group capable of reacting with the first or second reactive functional group to form a linkage in a coupling reaction in the presence or absence of a coupling agent to form the prepolymer, wherein the first, second and third reactive functional groups independent of each other are selected from the group consisting of amino group, hydroxyl group, carboxyl group, acid halide group, azlactone group, isocyanate group, epoxy group, aziridine group, and combination thereof wherein the linear chain-extended polysiloxane crosslinker comprises (a) two terminal ethylenically unsaturated groups, (b) at least two polysiloxane segments, and (c) at least one dangling hydrophilic polymer chain covalently attached to a divalent organic radical separating said at least two polysiloxane segments, wherein the linear chain extended polysiloxane crosslinker is as set forth by formula (I) - View Dependent Claims (2, 4, 5)
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3. An ophthalmic lens, comprising a silicone hydrogel material that is obtained by curing, in a mold, a lens-forming composition including a linear chain-extended polysiloxane crosslinker comprising (a) two terminal ethylenically unsaturated groups, (b) at least two polysiloxane segments, and (c) at least one dangling hydrophilic polymer chain covalently attached to a divalent organic radical separating said at least two polysiloxane segments, wherein the linear chain extended polysiloxane crosslinker is as set forth by formula (I)
Specification