Methods and compositions for articular repair

• US 9,055,953 B2
• Filed: 05/11/2010
• Issued: 06/16/2015
• Est. Priority Date: 05/25/2001
• Status: Expired due to Term

• Current Assignee: Conformis Incorporated
• Original Assignee: Conformis Incorporated
• Inventors: Lang, Philipp, Steines, Daniel
• Primary Examiner(s): Philogene, Pedro
• Application Number:
  US12/777,809
• Publication Number:
  US 20100303313A1
• Time in Patent Office: 1,862 Days
• Field of Search: 606/102, 606/86.R, 606 79- 85, 606/86.A, 606/96, 606 87- 89, 623/16.11, 623/18.11, 623/20.14, 623/20.21, 623/20.35, 623/23.61, 623/914, 623/916, 705 2- 3, 703 1- 2, 600/407, 600/410, 600/427, 600/587, 382/128
• US Class Current: 1/1
• CPC Class Codes: A61B 17/1662 for particular parts of the body
• CPC Class Codes: A61B 17/8805 for introducing fluid filler into bone or extracting it A61B17/7097, A61B17/8833 take precedence
• CPC Class Codes: A61B 5/4504 Bones A61B5/4547 takes precedence
• CPC Class Codes: A61B 5/4514 Cartilage
• CPC Class Codes: A61B 5/4528 Joints A61B5/4533, A61B5/4538 take precedence
• CPC Class Codes: A61F 2/30756 Cartilage endoprostheses A61F2/3603 takes precedence
• CPC Class Codes: A61F 2/30767 Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
• CPC Class Codes: A61F 2/30942 for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
• CPC Class Codes: A61F 2/3859 Femoral components
• CPC Class Codes: A61F 2/389 Tibial components A61F2/3868 takes precedence
• CPC Class Codes: A61F 2002/30062 (bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
• CPC Class Codes: A61F 2002/30677 Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
• CPC Class Codes: A61F 2002/30787 inclined obliquely with respect to each other
• CPC Class Codes: A61F 2002/30948 using computerized tomography, i.e. CT scans
• CPC Class Codes: A61F 2002/30957 using a positive or a negative model, e.g. moulds
• CPC Class Codes: A61F 2002/3097 using laser
• CPC Class Codes: A61F 2002/4631 the prosthesis being specially adapted for being cemented
• CPC Class Codes: A61F 2210/0004 bioabsorbable
• CPC Class Codes: A61F 2310/00011 Metals or alloys
• CPC Class Codes: A61F 2310/00017 Iron- or Fe-based alloys, e.g. stainless steel
• CPC Class Codes: A61F 2310/00023 : Titanium or titanium-based alloys, e.g. Ti-Ni alloys
• CPC Class Codes: A61F 2310/00029 : Cobalt-based alloys, e.g. Co-Cr alloys or Vitallium
• CPC Class Codes: A61F 2310/00047 : Aluminium or Al-based alloys
• CPC Class Codes: A61F 2310/00065 : Manganese or Mn-based alloys
• CPC Class Codes: A61F 2310/00071 : Nickel or Ni-based alloys
• CPC Class Codes: A61F 2310/00077 : Copper or Cu-based alloys
• CPC Class Codes: A61F 2310/00083 : Zinc or Zn-based alloys
• CPC Class Codes: A61F 2310/00107 : Palladium or Pd-based alloys
• CPC Class Codes: A61F 2310/00113 : Silver or Ag-based alloys
• CPC Class Codes: A61F 2310/00119 : Tin or Sn-based alloys
• CPC Class Codes: A61F 2310/00131 : Tantalum or Ta-based alloys
• CPC Class Codes: A61F 2310/00149 : Platinum or Pt-based alloys
• CPC Class Codes: A61F 2310/00155 : Gold or Au-based alloys
• CPC Class Codes: A61F 2310/00293 : containing a phosphorus-containing compound, e.g. apatite
• CPC Class Codes: A61F 2310/00383 : Gelatin
• CPC Class Codes: A61F 2310/00395 : Coating or prosthesis-covering structure made of metals or of alloys
• CPC Class Codes: A61F 2310/00592 : Coating or prosthesis-covering structure made of ceramics or of ceramic-like compounds
• CPC Class Codes: B33Y 80/00 : Products made by additive manufacturing
• CPC Class Codes: G06F 18/00 : Pattern recognition
• CPC Class Codes: G06F 30/00 : Computer-aided design [CAD]
• CPC Class Codes: Y10T 29/49 : Method of mechanical manufacture

Abstract

Disclosed herein are methods and compositions for producing articular repair materials and for repairing an articular surface. In particular, methods for providing articular repair systems. Also provided are articular surface repair systems designed to replace a selected area cartilage, for example, and surgical tools for repairing articular surfaces.

Claims

1. A surgical instrument for the repair of a diseased articular joint surface of a joint, comprising:

an inner surface having a curvature or shape based on information from image data of the diseased articular joint surface; and

a slit defining a cutting path through at least a portion of the joint when the inner surface is applied to the diseased articular joint surface.

2. The surgical instrument of claim 1, wherein the inner surface matches a shape of the diseased articular joint surface.

3. The surgical instrument of claim 1, wherein the inner surface matches a size of the diseased articular joint surface.

4. The surgical instrument of claim 1, wherein the inner surface matches a size of diseased cartilage of the diseased articular joint surface.

5. The surgical instrument of claim 1, wherein the inner surface matches a curvature of diseased cartilage of the diseased articular joint surface.

6. The surgical instrument of claim 1, wherein the inner surface matches a shape of diseased cartilage of the diseased articular joint surface.

7. The surgical instrument of claim 1, wherein the inner surface matches a curvature of subchondral bone of the diseased articular joint surface.

8. The surgical instrument of claim 1, wherein the inner surface matches a shape of subchondral bone of the diseased articular joint surface.

9. The surgical instrument of claim 1, wherein the inner surface matches a curvature of subchondral bone underlying diseased cartilage of the diseased articular joint surface.

10. The surgical instrument of claim 1, wherein the inner surface includes information of cartilage of the diseased articular joint surface.

11. The surgical instrument of claim 1, wherein the inner surface includes information of subchondral bone of the diseased articular joint surface.

12. A surgical instrument for the repair of a diseased or damaged cartilage surface of a joint, comprising:

an inner surface having a curvature or shape based on information from image data of the diseased or damaged cartilage surface; and

a slit defining a cutting path through at least a portion of the joint when the inner surface is applied to the diseased or damaged cartilage surface.

13. The surgical instrument of claim 12, wherein the inner surface matches a shape of the diseased or damaged cartilage surface.

14. The surgical instrument of claim 12, wherein the inner surface matches a size of the diseased or damaged cartilage surface.

15. The surgical instrument of claim 12, wherein the inner surface matches a curvature of the diseased or damaged cartilage surface.

16. The surgical instrument of claim 12, wherein the inner surface matches a shape of the diseased or damaged cartilage surface.

17. The surgical instrument of claim 12, wherein the inner surface matches a shape of subchondral bone underlying the diseased or damaged cartilage surface.

18. The surgical instrument of claim 12, wherein the inner surface matches a curvature of subchondral bone underlying diseased cartilage of the diseased articular joint surface.

19. The surgical instrument of claim 12, wherein the inner surface includes information of cartilage of the diseased or damaged cartilage surface.

20. The surgical instrument of claim 12, wherein the inner surface includes information of subchondral bone underlying the diseased or damaged cartilage surface.

21. A surgical instrument for the repair of a diseased articular joint surface of a joint, comprising:

an inner surface having a curvature or shape that matches a curvature or shape of the diseased articular joint surface; and

a slit defining a cutting path through at least a portion of the joint when the inner surface is applied to the diseased articular joint surface.

22. The surgical instrument of claim 21, wherein the inner surface matches a shape of the diseased articular joint surface.

23. The surgical instrument of claim 21, wherein the inner surface matches a size of the diseased articular joint surface.

24. The surgical instrument of claim 21, wherein the inner surface matches a size of diseased cartilage of the diseased articular joint surface.

25. The surgical instrument of claim 21, wherein the inner surface matches a curvature of diseased cartilage of the diseased articular joint surface.

26. The surgical instrument of claim 21, wherein the inner surface matches a shape of diseased cartilage of the diseased articular joint surface.

27. The surgical instrument of claim 21, wherein the inner surface matches a curvature of subchondral bone of the diseased articular joint surface.

28. The surgical instrument of claim 21, wherein the inner surface matches a shape of subchondral bone of the diseased articular joint surface.

29. The surgical instrument of claim 21, wherein the inner surface matches a curvature of subchondral bone underlying diseased cartilage of the diseased articular joint surface.

30. The surgical instrument of claim 21, wherein the inner surface includes information of cartilage of the diseased articular joint surface.

31. The surgical instrument of claim 21, wherein the inner surface includes information of subchondral bone of the diseased articular joint surface.

32. A surgical instrument for the repair of a diseased articular joint surface of a joint, comprising:

an inner surface having a curvature that matches a curvature of cartilage of the diseased articular joint surface; and

a slit defining a cutting path through at least a portion of the joint when the inner surface is applied to the diseased articular joint surface.

33. The surgical instrument of claim 32, wherein the inner surface matches the shape of the diseased articular joint surface.

34. The surgical instrument of claim 32, wherein the inner surface matches a size of the diseased articular joint surface.

35. The surgical instrument of claim 32, wherein the inner surface matches a size of diseased cartilage of the diseased articular joint surface.

36. The surgical instrument of claim 32, wherein the inner surface matches a shape of diseased cartilage of the diseased articular joint surface.

37. The surgical instrument of claim 32, wherein the inner surface matches a curvature of subchondral bone of the diseased articular joint surface.

38. The surgical instrument of claim 32, wherein the inner surface matches a shape of subchondral bone of the diseased articular joint surface.

39. The surgical instrument of claim 32, wherein the inner surface matches a curvature of subchondral bone underlying diseased cartilage of the diseased articular joint surface.

40. The surgical instrument of claim 32, wherein the inner surface includes information of the cartilage of the diseased articular joint surface.

41. The surgical instrument of claim 32, wherein the inner surface includes information of subchondral bone of the diseased articular joint surface.

42. A surgical instrument for the repair of a diseased articular joint surface of a joint, comprising:

an inner surface having a curvature that matches a curvature of subchondral bone of the diseased articular joint surface; and

a slit defining a cutting path through at least a portion of the joint when the inner surface is applied to the diseased articular joint surface.

43. The surgical instrument of claim 42, wherein the inner surface matches a shape of the diseased articular joint surface.

44. The surgical instrument of claim 42, wherein the inner surface matches a size of the diseased articular joint surface.

45. The surgical instrument of claim 42, wherein the inner surface matches a size of diseased cartilage of the diseased articular joint surface.

46. The surgical instrument of claim 42, wherein the inner surface matches a shape of diseased cartilage of the diseased articular joint surface.

47. The surgical instrument of claim 42, wherein the inner surface matches a curvature of diseased cartilage of the diseased articular joint surface.

48. The surgical instrument of claim 42, wherein the subchondral bone underlies diseased cartilage of the diseased articular joint surface.

49. The surgical instrument of claim 42, wherein the inner surface includes information of cartilage of the diseased articular joint surface.

50. A surgical device for preparing a recipient site in a diseased or damaged joint of a patient,

wherein at least a portion of the surgical device has a shape that matches an articular shape of the diseased or damaged joint of the patient, and

wherein the surgical device includes a slit configured to guide a surgical blade.

51. The surgical device of claim 50, wherein the articular shape of the diseased or damaged joint of the patient is derived from an electronic image.

52. The surgical device of claim 51, wherein the electronic image includes a digital image obtained with one or more x-ray based techniques selected from the group consisting of computed or digital radiography, ultrasound, computed tomography (CT), nuclear scintigraphy, SPECT, positron emission tomography and MRI.

53. The surgical device of claim 51, wherein the electronic image includes information associated with the diseased or damaged joint of the patient.

54. The surgical device of claim 53, wherein the information includes information about curvature of subchondral bone, curvature of cartilage, cartilage thickness, cartilage volume, dimensions and volume of soft and hard tissues associated with the diseased or damaged joint of the patient.

55. The surgical device of claim 54, wherein the information includes thickness of the normal or diseased cartilage surrounding a cartilage defect of the diseased or damaged joint of the patient.

56. The surgical device of claim 50, wherein a shape of the surgical device matches a shape slightly larger than the area of diseased or damaged joint of the patient.

57. The surgical device of claim 50, wherein a shape of the area of diseased or damaged joint includes a shape of tissue surrounding or adjacent diseased cartilage.

58. The surgical device of claim 50, wherein the device is disposable.

59. The surgical device of claim 50, wherein the device is integrally formed.

60. The surgical device of claim 50, wherein the device is made of a plastic.

61. A surgical device for preparing a recipient site in a diseased or damaged joint of a patient,

wherein at least a portion of the surgical device has a shape that matches an articular shape of the diseased or damaged joint of the patient, and

wherein the surgical device includes a holding mechanism configured to guide a surgical blade.