Method and device for drug delivery

• US 9,056,167 B2
• Filed: 03/19/2013
• Issued: 06/16/2015
• Est. Priority Date: 03/19/2007
• Status: Active Grant

• Current Assignee: InsuLine Medical Ltd.
• Original Assignee: InsuLine Medical Ltd.
• Inventors: Pesach, Benny, Bitton, Gabriel, Nagar, Ron, Weiss, Ram
• Primary Examiner(s): BOUCHELLE, LAURA A
• Application Number:
  US13/847,259
• Publication Number:
  US 20130226079A1
• Time in Patent Office: 819 Days
• Field of Search: 604 65- 67
• US Class Current: 1/1
• CPC Class Codes: A61M 2005/14296 Pharmacokinetic models
• CPC Class Codes: A61M 2005/1726 the body parameters being measured at, or proximate to, the infusion site
• CPC Class Codes: A61M 2205/3368 Temperature
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 2205/60 with identification means
• CPC Class Codes: A61M 2230/201 Glucose concentration
• CPC Class Codes: A61M 2230/50 Temperature
• CPC Class Codes: A61M 2230/63 Motion, e.g. physical activity
• CPC Class Codes: A61M 5/14248 of the skin patch type
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: G16H 10/60 for patient-specific data, e.g. for electronic patient records
• CPC Class Codes: G16H 20/10 relating to drugs or medications, e.g. for ensuring correct administration to patients
• CPC Class Codes: G16H 20/17 delivered via infusion or injection
• CPC Class Codes: G16H 40/63 for local operation
• CPC Class Codes: G16H 50/20 for computer-aided diagnosis, e.g. based on medical expert systems

Abstract

An apparatus and a system for controlling and/or managing administration of a drug to a body of a patient. The apparatus includes a drug infusion device configured to deliver drug at a predetermined location in the body of the patient, at least one sensor disposed in the drug infusion device and configured to measure a. corresponding property related to the patient and selected from the group consisting of physiological properties, biochemical properties, environmental properties and drug-related properties, a controller disposed in the drug infusion device and configured to receive from the at least one sensor data representative of the measured corresponding property and based on the received data, determine a drug delivery rate. The drug delivery device is configured to deliver the drug to the body of the patient based on the determined drug delivery rate.

Claims

1. An apparatus to control administration of a drug to the body of a patient, the apparatus comprising:

a drug infusion device configured to deliver the drug at a predetermined location on the body of the patient;

at least one sensor disposed in the drug infusion device and configured to measure a property related to the patient, wherein the property is a combination of a physiological property related to the patient, a biochemical property related to the patient, including a drug level in the blood of the patient and/or a rate of change of drug level in the blood of the patient, an environmental property related to the patient, including an ambient temperature, and a drug-related property, including quality of the drug being administered;

a controller disposed in the drug infusion device and configured to receive from the at least one sensor data representative of the measured property and further configured to determine a drug delivery rate or dose based on the received data;

the drug delivery device is further configured to deliver the drug to the body of the patient based on the determined drug delivery rate or dose; and

a user interface in communication with the controller and configured to receive input data to enable control of any one of;

the quantity of the administered drug, timing of administration of a single dose of the drug, timing of administration of a plurality of doses of the drug, rate administration of a single dose of the drug and timing of administration of a plurality of doses of the drug.

2. The apparatus according to claim 1, wherein the drug is insulin and the input data includes at least one of:

timing of the meal, meal composition, physical activity and illness status.

3. The apparatus according to claim 1, wherein the controller is configured to adjust the drug delivery rate or dose based on the input data.

4. The apparatus according to claim 1, wherein the controller is configured to increase the drug delivery rate at a first hour of a carbohydrate rich meal and/or decrease the drug delivery rate at a first hour of a fat rich meal.

5. The apparatus according to claim 1, wherein the user interface is configured to enable the user or any other individual to view data received from the at least one sensor.

6. The apparatus according to claim 1, wherein the drug is a pain relief drug and the input data comprises a level of pain or data related to the effect of the pain relief drug.

7. An apparatus to control administration of a drug to the body of a patient, the apparatus comprising:

a drug infusion device configured to deliver the drug at a predetermined location on the body of the patient;

at least one sensor disposed in the drug infusion device and configured to measure a property related to the patient, wherein the property is a combination of a physiological property related to the patient, a biochemical property related to the patient, including a drug level in the blood of the patient and/or a rate of change of drug level in the blood of the patient, an environmental property related to the patient, including an ambient temperature, and a drug-related property, including quality of the drug being administered;

a controller disposed in the drug infusion device and configured to receive from the at least one sensor data representative of the measured property and further configured to determine a drug delivery rate or dose based on the received data; and

the drug delivery device is further configured to deliver the drug to the body of the patient based on the determined drug delivery rate or dose, said received data used to detect disconnection or leakage of the drug from the infusion device.

8. The apparatus according to claim 7, wherein the sensor comprises a skin temperature sensor, and the disconnection or leakage is determined based on detection of variations of the skin temperature sensor.

9. The apparatus according to claim 7, wherein the measured property comprises a state of the patient selected from any one of:

a high level of physical activity, medium level of physical activity, low level of physical activity or sleep, the controller being configured to adjust the drug delivery rate or dose, based on the state of the patient.