Methods and systems for analyte measurement
First Claim
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1. A system for determining a value associated with an analyte in a sample, the system comprising:
- a radiation source configured to direct radiation to be incident on the sample;
a detector configured to detect radiation from the sample; and
an electronic processor configured to;
obtain measured spectral information about the sample based on the detected radiation;
compare the measured spectral information to a set of reference spectra determined from a model for light attenuation in the sample to identify a member of the set of reference spectra that corresponds to the measured spectral information;
correct the identified member of the set of reference spectra using a set of spectral correction factors determined from the set of reference spectra;
select a subset of the reference spectra and use only the selected subset of the reference spectra to determine values of parameters associated with a calibration equation; and
use the corrected identified member of the set of reference spectra as input to a calibration equation to determine the value associated with the analyte,wherein the electronic processor is further configured to select the subset of the reference spectra by;
determining, for each of multiple subsets of the reference spectra, a set of values of the parameters associated with the calibration equation;
determining a value of an error term associated with each set of values of the parameters; and
selecting the subset of the reference spectra that produces the set of values of the parameters having the smallest error term.
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Abstract
Methods are disclosed for determining a value associated with an analyte in a sample. The methods include: determining a set of spectra from a model for light attenuation in the sample, where the model includes contributions from at least two different sources of light attenuation in the sample; determining a set of spectral correction factors associated with the analyte in the sample based on the set of spectra; and using the set of spectral correction factors to determine the value associated with the analyte of interest.
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Citations
16 Claims
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1. A system for determining a value associated with an analyte in a sample, the system comprising:
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a radiation source configured to direct radiation to be incident on the sample; a detector configured to detect radiation from the sample; and an electronic processor configured to; obtain measured spectral information about the sample based on the detected radiation; compare the measured spectral information to a set of reference spectra determined from a model for light attenuation in the sample to identify a member of the set of reference spectra that corresponds to the measured spectral information; correct the identified member of the set of reference spectra using a set of spectral correction factors determined from the set of reference spectra; select a subset of the reference spectra and use only the selected subset of the reference spectra to determine values of parameters associated with a calibration equation; and use the corrected identified member of the set of reference spectra as input to a calibration equation to determine the value associated with the analyte, wherein the electronic processor is further configured to select the subset of the reference spectra by; determining, for each of multiple subsets of the reference spectra, a set of values of the parameters associated with the calibration equation; determining a value of an error term associated with each set of values of the parameters; and selecting the subset of the reference spectra that produces the set of values of the parameters having the smallest error term. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A system for determining a value associated with an analyte in a sample, the system comprising:
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a radiation source configured to direct radiation to be incident on the sample; a detector configured to detect radiation from the sample; and an electronic processor configured to; determine values of a set of parameters associated with a calibration equation for calculating the value of the analyte based on a set of reference spectra determined from a model for light attenuation in the sample and not on measured spectral information; identify a member of the set of reference spectra that most closely corresponds to measured spectral information for the sample; and determine the value associated with the analyte by using the identified member as input to the calibration equation, wherein the electronic processor is configured to determine the values of the set of parameters by; determining, for each of multiple subsets of the reference spectra, a set of values of the parameters associated with the calibration equation; determining a value of an error term associated with each set of values of the parameters; and using the set of values of the parameters having the smallest associated error term to determine the value associated with the analyte. - View Dependent Claims (12, 13, 14, 15, 16)
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Specification