Flowometry in optical coherence tomography for analyte level estimation
First Claim
1. A system for determining an indication of fluid flow in a tissue sample, the system comprising:
- an optical coherency tomography apparatus configured to obtain intensity data measurements from a region in a tissue sample; and
a processor configured to analyze the intensity data measurements from the optical coherency tomography apparatus to determine an indication of fluid flow in the region by at least;
passing the intensity data measurements through a first band-pass filter having a first bandwidth centered at a base frequency to produce a first output;
passing the intensity data measurements through a second band-pass filter having a second bandwidth that is wider than the first bandwidth and centered at the base frequency to produce a second output; and
comparing the first and second outputs to determine the indication of fluid flow in the region.
2 Assignments
0 Petitions
Accused Products
Abstract
Optical coherence tomography (herein “OCT”) based analyte monitoring systems are disclosed. In one aspect, techniques are disclosed that can identify fluid flow in vivo (e.g., blood flow), which can act as a metric for gauging the extent of blood perfusion in tissue. For instance, if OCT is to be used to estimate the level of an analyte (e.g., glucose) in tissue, a measure of the extent of blood flow can potentially indicate the presence of an analyte correlating region, which would be suitable for analyte level estimation with OCT. Another aspect is related to systems and methods for scanning multiple regions. An optical beam is moved across the surface of the tissue in two distinct manners. The first can be a coarse scan, moving the beam to provide distinct scanning positions on the skin. The second can be a fine scan where the beam is applied for more detailed analysis.
891 Citations
20 Claims
-
1. A system for determining an indication of fluid flow in a tissue sample, the system comprising:
-
an optical coherency tomography apparatus configured to obtain intensity data measurements from a region in a tissue sample; and a processor configured to analyze the intensity data measurements from the optical coherency tomography apparatus to determine an indication of fluid flow in the region by at least; passing the intensity data measurements through a first band-pass filter having a first bandwidth centered at a base frequency to produce a first output; passing the intensity data measurements through a second band-pass filter having a second bandwidth that is wider than the first bandwidth and centered at the base frequency to produce a second output; and comparing the first and second outputs to determine the indication of fluid flow in the region. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
-
-
15. A method of determining an indication of fluid flow in a tissue sample, the method comprising:
-
scanning a region in a tissue sample using an optical coherency tomography apparatus to obtain intensity data measurements; analyzing, by a processor configured to analyze the intensity data measurements from the optical coherency tomography apparatus, the intensity data measurements to determine an indication of fluid flow in the region by at least; passing the intensity data measurements through a first band-pass filter having a first bandwidth centered at a base frequency to produce a first output; passing the intensity data measurements through a second band-pass filter having a second bandwidth that is wider than the first bandwidth and centered at the base frequency to produce a second output; and
comparing the first and second outputs to determine the indication of fluid flow in the region. - View Dependent Claims (16, 17, 18, 19, 20)
-
Specification