Catheter-focused magnetic field induced renal nerve ablation

• US 9,060,761 B2
• Filed: 11/09/2011
• Issued: 06/23/2015
• Est. Priority Date: 11/18/2010
• Status: Expired due to Fees

• Current Assignee: Boston Scientific Scimed, Inc. (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Inventors: Hastings, Roger, Smith, Scott, Richardson, Leonard B., Jenson, Mark L.
• Primary Examiner(s): Koharski, Christopher D
• Assistant Examiner(s): CAREY, MICHAEL JAMES
• Application Number:
  US13/292,766
• Publication Number:
  US 20120130362A1
• Time in Patent Office: 1,322 Days
• Field of Search: 606/33, 606/41
• US Class Current: 1/1
• CPC Class Codes: A61B 18/04 by heating by applying electromagnetic radiation A61B18/18; hyperthermia using electric or magnetic fields, radiation or ultrasound A61N
• CPC Class Codes: A61B 2018/00023 closed, i.e. without wound contact by the fluid
• CPC Class Codes: A61B 2018/00404 Blood vessels other than those in or around the heart
• CPC Class Codes: A61B 2018/00434 Neural system
• CPC Class Codes: A61B 2018/00511 Kidney
• CPC Class Codes: A61B 2018/00577 Ablation

Abstract

A flexible catheter includes a magnetically permeable element provided at its distal end. The magnetically permeable element is configured for placement within the renal artery. External coils, positionable on anterior and posterior portions of a patient in proximity to the renal artery, are coupled to a generator which energizes the external coils to create a high-frequency oscillating magnetic field in body tissue between the external coils including the renal artery and perivascular renal nerve tissue. The magnetically permeable element serves to concentrate the magnetic field in a region near the renal artery. The concentrated magnetic field induces high frequency electric current sufficient to ablate the perivascular renal nerve tissue proximate the renal artery. A cooling arrangement can be provided at the catheter'"'"'s distal end and configured to provide cooling to the renal artery during ablation of the perivascular renal nerve tissue.

Claims

1. A system, comprising:

an internal apparatus intended to be deployed within a patient, the internal apparatus including;

a flexible elongated member comprising a proximal end, a distal end, and a length sufficient to access a target vessel of the body relative to a percutaneous access location; and

a magnetically permeable element provided at a distal end of the elongated member, the magnetically permeable element having poor electrical conductivity and configured for placement within the target vessel and adjacent a wall of the target vessel; and

an external apparatus intended to be deployed outside of the patient, the external apparatus including;

one or more external coils positionable on one or both of anterior and posterior portions of a patient in proximity to the target vessel; and

a generator coupled to the external coils and configured to energize the external coils to create a high-frequency oscillating magnetic field in body tissue between the external coils including the target vessel and target tissue proximate the target vessel;

wherein the magnetically permeable element serves to concentrate the magnetic field, created by the external apparatus, in a region near the target vessel, the concentrated magnetic field inducing high frequency electric current sufficient to ablate the target tissue proximate the vessel.

2. The system of claim 1, wherein the magnetically permeable element comprises a vessel filled with fluid comprising magnetic material.

3. The system of claim 1, wherein the magnetically permeable element comprises a balloon, the balloon configured to receive a fluid comprising magnetic material.

4. The system of claim 1, wherein the magnetically permeable element comprises a balloon, the balloon formed from a composite material comprising magnetic material or comprising a coating of nonconductive or poorly conductive magnetic material.

5. The system of claim 1, wherein:

the magnetically permeable element comprises a balloon;

at least a circumferential region of the balloon is heated by the induced electric current; and

a complete circumferential region of the target tissue in proximity to the circumferential region of the balloon is ablated.

6. The system of claim 1, wherein the magnetically permeable element comprises a solid element or a coated element, the solid or coated element comprising nonconductive or poorly conductive magnetic material.

7. The system of claim 1, wherein the magnetically permeable element comprises a tube containing magnetic material.

8. The system of claim 1, wherein the magnetically permeable element comprises paramagnetic material and diamagnetic material arranged in geometries that enhance heating of the target tissue.

9. The system of claim 1, wherein the magnetically permeable element is configured to cooperate with an external bird cage coil that generates a rotating magnetic field, the magnetically permeable element configured to distort a magnetic field proximate the element so that time varying electric fields are produced that circulate in the target tissue at the rotation rate of rotating magnetic field.

10. The system of claim 1, further comprising a temperature sensor arranged to sense temperature proximate the magnetically permeable element.

11. The system of claim 1, further comprising a cooling arrangement at the distal end of the elongated member and configured to provide cooling to the target vessel during ablation of the target tissue.

12. The system of claim 1, wherein the magnetically permeable element is configured to create a circumferential lesion in the target tissue.

13. The system of claim 1, wherein the concentrated magnetic field is approximately 5-15 times greater than that in other regions of the body tissue between the external coils.

14. The system of claim 1, wherein the induced current causes local resistive heating near the magnetically permeable element approximately ≧

100 times that in other areas of the body tissue subject to the magnetic field.

15. The system of claim 1, further comprising a cooling arrangement configured to cool the one or more external coils.

16. A system comprising:

a flexible elongated member comprising a proximal end, a distal end, and a length sufficient to access a renal artery relative to a percutaneous access location;

a magnetically permeable element provided at a distal end of the elongated member, the magnetically permeable element having poor electrical conductivity and configured for placement within the renal artery and adjacent a wall of the renal artery, the magnetically permeable element deployable within a patient;

one or more external coils positionable on one or both of anterior and posterior portions of the patient, exterior to the patient;

in proximity to the renal artery; and

a generator coupled to the external coils and configured to energize the external coils to create a high-frequency oscillating magnetic field in body tissue between the external coils including the renal artery and perivascular renal nerve tissue proximate the renal artery;

the magnetically permeable element serving to concentrate the magnetic field in a region near the renal artery, the concentrated magnetic field inducing high frequency electric current sufficient to ablate the perivascular renal nerve tissue proximate the renal artery.

17. The system of claim 16, further comprising a cooling arrangement at the distal end of the elongated member and configured to provide cooling to the renal artery during ablation of the perivascular renal nerve tissue.

18. The system of claim 16, further comprising a cooling arrangement configured to cool the one or more external coils.

19. The system of claim 16, wherein the magnetically permeable element is configured to create a circumferential lesion in the perivascular renal nerve tissue.

20. The system of claim 16, wherein:

the magnetically permeable element comprises a balloon; and

the balloon comprises a cooling arrangement configured to provide cooling to the renal artery during ablation of the perivascular renal nerve tissue.

21. A method, comprising:

energizing one or more external coils positionable on one or both of anterior and posterior portions of a patient in proximity to a renal artery to create a high-frequency oscillating magnetic field in body tissue between the external coils including renal artery tissue and perivascular renal nerve tissue adjacent the renal artery;

concentrating the magnetic field in a region near the renal artery; and

ablating the perivascular renal nerve tissue using high frequency electric current induced in the perivascular renal nerve tissue by the concentrated magnetic field.

22. The method of claim 21, wherein:

concentrating the magnetic field comprises concentrating the magnetic field in a region near a magnetically permeable element situated in the renal artery; and

ablating the perivascular renal nerve tissue comprises ablating the perivascular renal nerve tissue using high frequency electric current induced in the perivascular renal nerve tissue proximate the magnetically permeable element by the concentrated magnetic field.

23. The method of claim 21, further comprising providing cooling to the renal artery during ablation of the perivascular renal nerve tissue.