Adhesive articles

• US 9,060,842 B2
• Filed: 11/19/2008
• Issued: 06/23/2015
• Est. Priority Date: 11/19/2007
• Status: Active Grant

• Current Assignee: Charles Stark Draper Laboratory Incorporated, Massachusetts Institute of Technology
• Original Assignee: Charles Stark Draper Laboratory Incorporated, Massachusetts Institute of Technology
• Inventors: Karp, Jeffrey, Alborz, Mahdavi, Ferreira, Lino, Carter, David, Zumbuehl, Andreas, Borenstein, Jeffrey, Chan, Edwin, Langer, Robert, Bettinger, Christopher
• Primary Examiner(s): Nia, Alireza
• Assistant Examiner(s): PATEL, TARLA R
• Application Number:
  US12/743,817
• Publication Number:
  US 20110021965A1
• Time in Patent Office: 2,407 Days
• Field of Search: 442/59, 442/149, 442/151, 442/150, 442/181, 442/295, 442/299, 442/FOR.100, 442/FOR.101, 442/FOR.121, 442/FOR.136, 442/FOR.137, 602/54, 602/42, 602/41, 602/55, 428/32.6, 428/32.77, 428/32.78, 428/32.79, 428/40.1, 428/41.9, 428/64.1, 428/64.2, 428/64.4, 428/65.2, 428/98, 428212-214, 156/1, 156/60, 156/290, 156/291, 156/325, 156/66, 606213-214, 424443-449
• US Class Current: 1/1
• CPC Class Codes: A61F 2/0077 Special surfaces of prostheses, e.g. for improving ingrowth A61F2/30767 takes precedence
• CPC Class Codes: A61F 2002/30448 using adhesives
• CPC Class Codes: A61F 2013/00774 arranged in discrete dots
• CPC Class Codes: A61F 2220/0016 with sharp anchoring protrusions, e.g. barbs, pins, spikes
• CPC Class Codes: A61F 2220/005 using adhesives
• CPC Class Codes: A61K 9/0019 Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner non-active ingredients are additionally classified in A61K47/00
• CPC Class Codes: A61L 15/42 Use of materials characterised by their function or physical properties liquid bandages A61L26/00
• CPC Class Codes: A61L 15/58 Adhesives
• CPC Class Codes: A61L 15/64 specially adapted to be resorbable inside the body
• CPC Class Codes: A61L 31/005 Ingredients of undetermined constitution or reaction products thereof
• CPC Class Codes: A61L 31/14 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61L 31/148 Materials at least partially resorbable by the body
• CPC Class Codes: B29C 65/18 using heated tools
• CPC Class Codes: B29C 65/52 characterised by the way of applying the adhesive B29C65/50 takes precedence; apparatus for applying liquids in general B05C; processes for applying liquids in general B05D
• CPC Class Codes: B29C 66/1122 Single lap to lap joints, i.e. overlap joints B29C66/45, B29C66/472, B29C66/52272 take precedence
• CPC Class Codes: B31B 2160/10 rectangular and flat, i.e. without structural provision for thickness of contents
• CPC Class Codes: B31B 70/81 Forming or attaching accessories, e.g. opening devices, closures or tear strings
• CPC Class Codes: C04B 37/005 consisting of glass or ceramic material

Abstract

An adhesive article includes a biocompatible and at least partially biodegradable substrate having a surface; and a plurality of protrusions extending from the surface. The protrusions include a biocompatible and at least partially biodegradable material, and have an average height of less than approximately 1,000 micrometers.

Claims

1. An adhesive article comprising:

a biocompatible and at least partially biodegradable substrate having a surface and protrusions extending from the surface;

wherein the protrusions comprise a biocompatible and at least partially biodegradable material,

wherein the protrusions have an average height of less than approximately 1,000 μ

m, and

wherein the protrusions have a tip width to pitch ratio (T/P) ranging from about 0.8 to about 0.1.

2. The adhesive article of claim 1, wherein the tip width to pitch ratio (T/P) is from about 0.6 to about 0.2.

3. The adhesive article of claim 1, wherein the protrusions have an average tip width of from approximately 0.05 μ

m to approximately 10 μ

m.

4. The adhesive article of claim 1, wherein the protrusions have an average base width of from approximately 0.05 μ

m to approximately 10 μ

m.

5. The adhesive article of claim 1, wherein the protrusions have a base width to tip width ratio (B/T) in the range of from about 2:

1 to about 20;

1.

6. The adhesive article of claim 1, wherein the protrusions have an average height of from approximately 0.25 μ

m to approximately 10 μ

m.

7. The adhesive article of claim 1, wherein the protrusions have an average center-to-center pitch from approximately 0.2 μ

m to approximately 100 μ

m.

8. The biocompatible adhesive article of claim 1, wherein the substrate comprises poly(glycerol sebacate) (PGS), poly(glycerol sebacate acrylate) (PGSA), poly(lactic-co-glycolic acid) (PLGA), polycaprolactone (PCL), polyglycolide (PGA), polylactic acid (PLA), poly-3-hydroxybutyrate (PHB), star-poly-caprolactone-co-D,L-lactide, poly(tri-methyl carbonate-co-caprolactone), poly(ethylene glycol) (PEG), polyurethane, parylene-C, poly(citric-diol), hyaluronic acid, dextran, chitosan, alginate, keratin, carbon nanotubes, or agrose.

9. The adhesive article of claim 1, wherein the biocompatible adhesive article further comprises a biomolecule or a pharmaceutical compound.

10. The adhesive article of claim 9, wherein the biomolecule or pharmaceutical compound is selected from the group consisting of anti-AIDS substances, anti-cancer substances, antibiotics, immunosuppressants, anti-viral substances, enzyme inhibitors, neurotoxins, opioids, hypnotics, anti-histamines, lubricants, tranquilizers, anti-convulsants, muscle relaxants and anti-Parkinson substances, anti-spasmodics and muscle contractants including channel blockers, miotics and anti-cholinergics, anti-glaucoma compounds, anti-parasite and/or antiprotozoal compounds, modulators of cell-extracellular matrix interactions including cell growth inhibitors and pro- or anti-adhesion molecules, vasodilating agents, inhibitors of DNA, RNA or protein synthesis, anti-hypertensives, analgesics, anti-pyretics, steroidal and non-steroidal anti-inflammatory agents, pro- or anti-angiogenic factors, pro- or anti-secretory factors, anticoagulants and/or antithrombotic agents, local anesthetics, ophthalmics, prostaglandins, antidepressants, anti-psychotic substances, anti-emetics, growth factors, proton pump inhibitors, hormones, vitamins, gene delivery systems, and imaging agents.

11. The adhesive article of claim 1, further comprising a plurality of cells.

12. The adhesive article of claim 11, wherein the plurality of cells comprises one or more kerotinocytes, fibroblasts, ligament cells, endothelial cells, lung cells, epithelial cells, smooth muscle cells, cardiac muscle cells, skeletal muscle cells, islet cells, nerve cells, hepatocytes, kidney cells, bladder cells, urothelial cells, stem cells, neurobalstoma, chondrocytes, skin cells and bone-forming cells.

13. The adhesive article of claim 1, further comprising an adherent layer having a moiety capable of bonding to the biological tissue.

14. The adhesive article of claim 13, wherein the moiety capable of bonding to the biological tissue comprises aldehydes.