Prosthetic valve

• US 9,060,855 B2
• Filed: 03/16/2012
• Issued: 06/23/2015
• Est. Priority Date: 10/13/2008
• Status: Active Grant

• Current Assignee: Ventor Technologies Ltd. (Medtronic Plc)
• Original Assignee: Ventor Technologies Ltd. (Medtronic Plc)
• Inventors: Tuval, Yosi, Kovalsky, Igor
• Primary Examiner(s): Sweet, Thomas J
• Assistant Examiner(s): Mathew, Seema
• Application Number:
  US13/422,716
• Publication Number:
  US 20130073030A1
• Time in Patent Office: 1,194 Days
• Field of Search: 623/1.24, 623 131- 132, 623/1.36, 623/2.1, 623/2.17
• US Class Current: 1/1
• CPC Class Codes: A61F 2/2403 with pivoting rigid closure members check valves with hinged closure members in general F16K15/03
• CPC Class Codes: A61F 2/2418 Scaffolds therefor, e.g. support stents
• CPC Class Codes: A61F 2/2427 Devices for manipulating or deploying heart valves during implantation
• CPC Class Codes: A61F 2/2436 Deployment by retracting a sheath
• CPC Class Codes: A61F 2230/0013 Horseshoe-shaped, e.g. crescent-shaped, C-shaped, U-shaped
• CPC Class Codes: A61F 2230/005 Rosette-shaped, e.g. star-shaped
• CPC Class Codes: A61F 2230/0078 hyperboloidal
• CPC Class Codes: A61F 2230/008 paraboloidal

Abstract

In some embodiments, an apparatus includes a valve prosthesis for attachment to a native valve complex of a subject. The prosthesis is configured to assume a compressed delivery state and an uncompressed implantation state. The prosthesis includes a support frame, which is shaped so as to define an upstream inlet having upstream-most portions that are tapered in an upstream direction toward a central longitudinal axis of the prosthesis when the prosthesis assumes the compressed delivery state, and a flexible prosthetic heart valve component, coupled to the support frame. Other embodiments are also described.

Claims

1. Apparatus comprising a valve prosthesis for attachment to a native valve complex of a subject, the prosthesis configured to assume a compressed delivery state and an uncompressed implantation state, the prosthesis comprising:

a support frame, which is shaped so as to define an upstream inlet having upstream-most ends that are tapered in an upstream direction toward a central longitudinal axis of the prosthesis when the prosthesis assumes the compressed delivery state, wherein the upstream-most ends of the inlet converge to within 2 mm of the central longitudinal axis when the prosthesis assumes the compressed delivery state; and

a flexible prosthetic heart valve component, coupled to the support frame.

2. The apparatus according to claim 1, wherein the upstream inlet has a greatest outer inlet diameter of at least 20 mm when the prosthesis assumes the uncompressed implantation state.

3. The apparatus according to claim 1, wherein the support frame is shaped so as to define a downstream section that is configured to apply an upstream axial force to a downstream side of the native valve complex, wherein the upstream inlet is configured to apply a downstream axial force on an upstream side of the native valve complex, and wherein the valve prosthesis is configured such that the upstream and downstream axial forces together anchor the valve prosthesis to the native valve complex.

4. The apparatus according to claim 1, wherein the upstream-most ends of the inlet converge at the central longitudinal axis when the prosthesis assumes the compressed delivery state.

5. The apparatus according to claim 1, wherein at least one of the upstream-most ends of the inlet converges at the central longitudinal axis when the prosthesis assumes the compressed delivery state.

6. The apparatus according to claim 1, wherein all parts of the inlet within 1 mm of an upstream end of the inlet are within 2 mm of the central longitudinal axis when the prosthesis assumes the compressed delivery state.

7. The apparatus according to claim 1, further comprising a delivery tube, wherein the prosthesis is configured to assume the compressed delivery state upon placement of the valve prosthesis partially within the delivery tube.

8. The apparatus according to claim 7, wherein the delivery tube is configured to prevent full insertion of the valve prosthesis into the delivery tube.

9. The apparatus according to claim 7, wherein the valve prosthesis has a marking that indicates a desired depth of insertion in a downstream direction of the valve prosthesis into the delivery tube.

10. The apparatus according to claim 7, wherein when the prosthesis assumes the uncompressed implantation state, the support frame is shaped so as to define two curved portions connected by an intermediary portion, such that when the intermediary portion is subjected to an upstream axial force applied by the delivery tube when the prosthesis is placed partially within the delivery tube, resulting vector component forces compress the upstream inlet toward the central longitudinal axis.

11. The apparatus according to claim 2, further comprising a delivery tube, wherein the prosthesis is configured to assume the compressed delivery state upon placement of the valve prosthesis partially within the delivery tube.

12. The apparatus according to claim 3, further comprising a delivery tube, wherein the prosthesis is configured to assume the compressed delivery state upon placement of the valve prosthesis partially within the delivery tube.

13. Apparatus comprising a valve prosthesis for attachment to a native valve complex of a subject, the prosthesis configured to assume a compressed delivery state and an uncompressed implantation state, the prosthesis comprising:

a support frame, which is shaped so as to define an upstream inlet having upstream-most ends that are tapered in an upstream direction toward a central longitudinal axis of the prosthesis when the prosthesis assumes the compressed delivery state;

a flexible prosthetic heart valve component, coupled to the support frame; and

a delivery tube, wherein the prosthesis is configured to assume the compressed delivery state upon placement of the valve prosthesis partially within the delivery tube, and wherein when the prosthesis assumes the compressed delivery state, a portion of the upstream inlet that extends outside of the delivery tube has a greatest outer inlet diameter that is greater than an outer tube diameter of the delivery tube.

15. The apparatus according to claim 13, wherein the upstream-most ends of the inlet converge to within 2 mm of the central longitudinal axis when the prosthesis assumes the compressed delivery state.

17. The apparatus according to claim 15, wherein all parts of the inlet within 1 mm of an upstream end of the inlet are within 2 mm of the central longitudinal axis when the prosthesis assumes the compressed delivery state.

14. Apparatus comprising a valve prosthesis for attachment to a native valve complex of a subject, the prosthesis configured to assume a compressed delivery state and an uncompressed implantation state, the prosthesis comprising:

a support frame, which is shaped so as to define an upstream inlet having upstream-most ends that are tapered in an upstream direction toward a central longitudinal axis of the prosthesis when the prosthesis assumes the compressed delivery state;

a flexible prosthetic heart valve component, coupled to the support frame; and

a delivery tube, wherein the prosthesis is configured to assume the compressed delivery state upon placement of the valve prosthesis partially within the delivery tube, and wherein when the prosthesis assumes the compressed delivery state, a portion of the upstream inlet that extends outside of the delivery tube has a greatest outer inlet diameter that is equal to an outer tube diameter of the delivery tube.

16. The apparatus according to claim 14, wherein the upstream-most ends of the inlet converge to within 2 mm of the central longitudinal axis when the prosthesis assumes the compressed delivery state.

18. The apparatus according to claim 16, wherein all parts of the inlet within 1 mm of an upstream end of the inlet are within 2 mm of the central longitudinal axis when the prosthesis assumes the compressed delivery state.