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Insulin formulations for rapid uptake

  • US 9,060,927 B2
  • Filed: 03/03/2009
  • Issued: 06/23/2015
  • Est. Priority Date: 03/03/2009
  • Status: Active Grant
First Claim
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1. A clear insulin solution having a pH of between greater than 7.0 and 7.6, consisting of insulin, one or more zinc chelators one or more dissolution agents and one or more excipients,wherein the insulin comprises dissociated insulin monomers produced by chelation of the zinc in insulin hexamers which are not soluble at a pH of between greater than 7.0 and 7.6,the dissociated insulin monomers have bound thereto charge masking agents which stabilize the dissociated insulin monomers,wherein the solution is prepared by raising the pH of an insulin solution from about pH 4.0 to a pH between a pH greater than 7.0 and a pH about 7.6, andwherein the insulin has an enhanced rate of uptake and transport through epithelial cells relative to the solution without the zinc chelator and dissolution agent.

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