Compositions and methods for surface abrasion with frozen particles
First Claim
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1. A method comprising:
- delivering at least one first frozen particle composition to at least one surface of at least one biological tissue of a subject by propulsion at a predetermined pressure;
wherein the at least one first frozen particle composition includes one or more frozen particles including one or more of an anti-tumor agent, epinephrine, neurotoxin, or enzyme;
wherein the one or more frozen particles have at least one major dimension of approximately one centimeter or less; and
subsequently delivering a second frozen particle composition to the at least one surface of the biological tissue by propulsion at a predetermined pressure;
wherein the second frozen particle composition includes one or more frozen particles including one or more of collagen, elastin, anesthetic, wherein the anesthetic is not epinephrine, or antibiotic.
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Abstract
Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.
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Citations
37 Claims
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1. A method comprising:
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delivering at least one first frozen particle composition to at least one surface of at least one biological tissue of a subject by propulsion at a predetermined pressure; wherein the at least one first frozen particle composition includes one or more frozen particles including one or more of an anti-tumor agent, epinephrine, neurotoxin, or enzyme; wherein the one or more frozen particles have at least one major dimension of approximately one centimeter or less; and subsequently delivering a second frozen particle composition to the at least one surface of the biological tissue by propulsion at a predetermined pressure; wherein the second frozen particle composition includes one or more frozen particles including one or more of collagen, elastin, anesthetic, wherein the anesthetic is not epinephrine, or antibiotic. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. A method comprising:
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delivering at least one first frozen particle composition to at least one biological tissue of a subject by propulsion at a predetermined pressure and in a manner sufficient to remove dead, damaged or infected tissue of the at least one biological tissue, wherein the at least one first frozen particle composition includes one or more frozen particles coated in one or more of an anti-tumor agent, epinephrine, neurotoxin, or enzyme, and including at least one of acetone, ethyl acetate, dimethyl formamide, dioxane, hexamethylphosphorotriamide, tert-butyl alcohol, formic acid, hydrogen fluoride, ammonia, acetic acid, benzene, carbon tetrachloride, acetonitrile, hexane, methylene chloride, or diethyl ether; wherein the one or more frozen particles have at least one major dimension of approximately one centimeter or less; and subsequently delivering a second frozen particle composition to the at least one surface of the biological tissue by propulsion at a predetermined pressure to form a scaffold; wherein the second frozen particle composition includes one or more frozen particles including one or more of collagen, elastin, or other extracellular matrix components. - View Dependent Claims (28, 29, 30, 31, 32, 33, 34, 35, 36, 37)
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Specification