Light and/or ultrasonic transducer device with sensor feedback for dose control

• US 9,061,128 B2
• Filed: 03/14/2014
• Issued: 06/23/2015
• Est. Priority Date: 03/15/2013
• Status: Active Grant

• Current Assignee: CareWear Corp.
• Original Assignee: Sonovia Holdings LLC
• Inventors: Castel, John C., Castel, Dawn, Hall, Michael R.
• Primary Examiner(s): Roy, Baisakhi
• Application Number:
  US14/214,188
• Publication Number:
  US 20140276248A1
• Time in Patent Office: 466 Days
• Field of Search: 600/407, 600/439, 600/476, 600/9, 604/20, 604/501, 601/2, 606/9
• US Class Current: 1/1
• CPC Class Codes: A61F 2007/0052 for treatment of skin or hair
• CPC Class Codes: A61F 2007/0071 using a resistor, e.g. near the spot to be heated
• CPC Class Codes: A61F 2007/0261 medicated
• CPC Class Codes: A61F 7/007 characterised by electric heating
• CPC Class Codes: A61M 37/0092 using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
• CPC Class Codes: A61N 1/0432 Anode and cathode
• CPC Class Codes: A61N 1/0452 Specially adapted for transcutaneous muscle stimulation [TMS]
• CPC Class Codes: A61N 1/30 Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
• CPC Class Codes: A61N 1/328 for improving the appearance of the skin, e.g. facial toning or wrinkle treatment
• CPC Class Codes: A61N 1/3603 Control systems
• CPC Class Codes: A61N 2005/0653 Organic light emitting diodes
• CPC Class Codes: A61N 2007/0034 Skin treatment
• CPC Class Codes: A61N 2007/0073 using multiple frequencies
• CPC Class Codes: A61N 5/0613 Apparatus adapted for a specific treatment
• CPC Class Codes: A61N 5/0616 Skin treatment other than tanning
• CPC Class Codes: A61N 7/00 Ultrasound therapy lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 ; using ultrasound for introducing media into the body A61M37/0092
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/06 Antipsoriatics
• CPC Class Codes: A61P 17/10 Anti-acne agents
• CPC Class Codes: A61P 17/18 Antioxidants, e.g. antiradicals preparations for protection against sunlight A61Q17/00
• CPC Class Codes: A61P 3/00 : Drugs for disorders of the metabolism of the blood or the extracellular fluid A61P7/00
• CPC Class Codes: A61P 3/02 : Nutrients, e.g. vitamins, minerals
• CPC Class Codes: A61P 35/00 : Antineoplastic agents

Abstract

A system for delivering light and/or ultrasound across a skin surface is provided. The system includes a device having a layered structure comprising one or both of a light source and an ultrasonic transducer. The light source comprises a flexible light emitter layer electrically coupled to a first conductive layer and a second conductive layer, wherein at least one of the first and second conductive layers is transparent. The ultrasonic transducer comprises a flexible ultrasound emitter layer electrically coupled to a third conductive layer and a fourth conductive layer. The system also includes one or more sensors in contact with the skin surface and a controller electrically coupled to the device and the sensor. The controller is operable to receive sensor data from the sensor and dynamically control the device in response to the received sensor data.

Claims

1. A system for delivering one or both of light and ultrasound across a skin surface to cause transdermal transport of a therapeutic or cosmetic composition through the skin surface, comprising:

a flexible device comprising one or both of;

(a) a light source for producing light, wherein the light source comprises a flexible light emitter layer comprising one of an organic light emitting diode or a plurality of printed light emitting diodes, wherein the flexible light emitter layer is electrically coupled to a first conductive layer and a second conductive layer, wherein at least one of the first and second conductive layers is transparent; and

(b) an ultrasonic transducer for producing ultrasound, wherein the ultrasonic transducer comprises a flexible ultrasound emitter layer comprising a piezoelectric coating, wherein the flexible ultrasound emitter layer is electrically coupled to a third conductive layer and a fourth conductive layer;

at least one sensor in contact with the skin surface; and

a controller electrically coupled to the device and the sensor, wherein the controller is operable to receive sensor data from the sensor and dynamically control the device in response to the received sensor data.

2. The system of claim 1, wherein the sensor is selected from the group consisting of impedance measurement sensors, RFID sensors, digital signature sensors, temperature sensors, light emission spectrum sensors, pressure sensors, light intensity sensors, infrared temperature sensors, electrical impedance sensors, ultrasonic transmitters and receivers, skin hydration sensors, skin sebum level sensors, skin melanin content sensors, skin elasticity sensors, skin pH sensors, skin color sensors, skin glossiness sensors, skin friction sensors, and skin fluorescence sensors.

3. The system of claim 1, wherein the controller dynamically adjusts an operating parameter of the device in response to the received sensor data.

4. The device of claim 3, wherein the controller independently controls the light source by adjusting the activation and deactivation of the light source, voltage, current, light wavelength, pulse width, modulation frequency, duty factor, or light treatment time.

5. The device of claim 3, wherein the controller independently controls the ultrasonic transducer by adjusting the activation and deactivation of the transducer, ultrasound treatment time, ultrasound frequency, or ultrasound modulation frequency.

6. The system of claim 3, wherein the device further comprises a flexible transparent heater layer that provides substantially uniform heating over a surface of the device facing the skin surface, and wherein the controller independently controls the heater layer by adjusting the activation or deactivation of the heater layers, voltage, current, or treatment time for the heater layer.

7. The system of claim 3, wherein the device further comprises an electrical stimulation layer, and wherein the controller independently controls the electrical stimulation layer by adjusting the activation or deactivation of the electrical stimulation layer, voltage, current, or treatment time for the electrical stimulation layer.

8. The system of claim 1, wherein the device further comprises a flexible printed circuit board layer that includes the controller.

9. The system of claim 1, wherein the therapeutic or cosmetic composition is contained in a hydrogel pad to be applied to the skin surface.

10. The system of claim 9, wherein the therapeutic or cosmetic composition includes one or more of low or high molecular weight hyaluronic acid, ascorbic acid (vitamin C) or alpha-tocopherol (vitamin E) or their derivatives or their pharmaceutically acceptable salts and esters.

11. The system of claim 1, wherein the controller is electrically coupled to a communication module that enables wired or wireless communication with an external control device, wherein the external control device is capable of executing a control application for externally controlling the controller.

12. The system of claim 11, wherein the external control device comprises one of a smart phone, a tablet computer, and a laptop computer.

13. The system of claim 11, wherein the external control device further communicates with a remote server to modify one or more treatment parameters based on information stored on the remote server.

14. The system of claim 1, wherein the sensor data is used to control the dose of one or both of the light and ultrasound produced by the device.

15. The system of claim 1, wherein the sensor data is used to provide at least one treatment recommendation.

16. A system for delivering one or both of light and ultrasound across a skin surface to cause transdermal transport of a therapeutic or cosmetic composition through the skin surface, comprising:

a plurality of flexible devices arranged in an array and held in proximity to each other by a flexible material, wherein each flexible device comprises one or both of;

(a) a light source for producing light, wherein the light source comprises a flexible light emitter layer comprising one of an organic light emitting diode or a plurality of printed light emitting diodes, wherein the flexible light emitter layer is electrically coupled to a first conductive layer and a second conductive layer, wherein at least one of the first and second conductive layers is transparent; and

(b) an ultrasonic transducer for producing ultrasound, wherein the ultrasonic transducer comprises a flexible ultrasound emitter layer comprising a piezoelectric coating, wherein the flexible ultrasound emitter layer is electrically coupled to a third conductive layer and a fourth conductive layer;

at least one power source for driving the devices;

at least one sensor in contact with the skin surface;

a plurality of controllers each of which is electrically coupled to one of the devices;

a main controller electrically couple to the sensor and each of the controllers, wherein the main controller is operable to receive sensor data from the sensor and dynamically control the devices through the controllers in response to the received sensor data.

17. The system of claim 16, wherein the main controller dynamically adjusts an operating parameter of each device in response to the received sensor data.

18. The system of claim 16, wherein the therapeutic or cosmetic composition is contained in a hydrogel pad to be applied to the skin surface.

19. The system of claim 18, wherein the therapeutic or cosmetic composition includes one or more of low or high molecular weight hyaluronic acid, ascorbic acid (vitamin C) or alpha-tocopherol (vitamin E) or their derivatives or their pharmaceutically acceptable salts and esters.

20. The system of claim 16, wherein the main controller is electrically coupled to a communication module that enables wired or wireless communication with an external control device, wherein the external control device is capable of executing a control application for externally controlling the main controller.

21. The system of claim 20, wherein the external control device comprises one of a smart phone, a tablet computer, and a laptop computer.

22. The system of claim 20, wherein the external control device further communicates with a remote server to modify one or more treatment parameters based on information stored on the remote server.

23. The system of claim 16, wherein the sensor data is used to control the dose of one or both of the light and ultrasound produced by the device.

24. The system of claim 16, wherein the sensor data is used to provide at least one treatment recommendation.

25. A system for delivering one or both of light and ultrasound across a skin surface to cause transdermal transport of a therapeutic or cosmetic composition through the skin surface, comprising:

a flexible device comprising one or both of;

(a) a light source for producing light, wherein the light source comprises a flexible light emitter layer comprising one of an organic light emitting diode or a plurality of printed light emitting diodes, wherein the flexible light emitter layer is electrically coupled to a first conductive layer and a second conductive layer, wherein at least one of the first and second conductive layers is transparent; and

(b) an ultrasonic transducer for producing ultrasound, wherein the ultrasonic transducer comprises a flexible ultrasound emitter layer comprising a piezoelectric coating, wherein the flexible ultrasound emitter layer is electrically coupled to a third conductive layer and a fourth conductive layer;

a controller operable to control the device; and

a communication module electrically coupled to the controller, wherein the communication module enables wired or wireless communication with an external control device, wherein the external control device executes a control application for externally controlling the controller.

26. The system of claim 25, further comprising at least one sensor in contact with the skin surface, wherein the controller receives sensor data from the sensor and is operable to (i) transmit the sensor data to the external control device whereby the sensor data is used to provide at least one treatment recommendation or (ii) dynamically control the device in response to the received sensor data so as to control the dose of one or both of the light and ultrasound produced by the device.

27. The system of claim 26, wherein the sensor is selected from the group consisting of impedance measurement sensors, RFID sensors, digital signature sensors, temperature sensors, light emission spectrum sensors, pressure sensors, light intensity sensors, infrared temperature sensors, electrical impedance sensors, ultrasonic transmitters and receivers, skin hydration sensors, skin sebum level sensors, skin melanin content sensors, skin elasticity sensors, skin pH sensors, skin color sensors, skin glossiness sensors, skin friction sensors, and skin fluorescence sensors.

28. The system of claim 25, wherein the external control device comprises one of a smart phone, a tablet computer, and a laptop computer.

29. The system of claim 25, wherein the external control device further communicates with a remote server to modify one or more treatment parameters based on information stored on the remote server.