Method of treating a patient

• US 9,061,153 B1
• Filed: 05/26/2014
• Issued: 06/23/2015
• Est. Priority Date: 04/20/2011
• Status: Active Grant

• Current Assignee: Tylerton International Inc.
• Original Assignee: MetaCure Limited (MetaCure (USA), Inc.)
• Inventors: Lebovitz, Harold, Goode, Paul, Haddad, Walid, Ben-Haim, Shlomo, Yaniv, Irit, Rousso, Benny
• Primary Examiner(s): Wieland, Robert N
• Application Number:
  US14/287,102
• Time in Patent Office: 393 Days
• Field of Search: 607/3
• US Class Current: 1/1
• CPC Class Codes: A61B 5/4836 Diagnosis combined with treatment in closed-loop systems or methods A61B5/0036 takes precedence
• CPC Class Codes: A61B 5/4866 Evaluating metabolism A61B5/083 takes precedence
• CPC Class Codes: A61B 5/4872 Body fat
• CPC Class Codes: A61K 31/216 of acids having aromatic rings, e.g. benactizyne, clofibrate
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: A61N 1/0509 Stomach and intestinal electrodes
• CPC Class Codes: A61N 1/36007 of urogenital or gastrointestinal organs, e.g. for incontinence control
• CPC Class Codes: A61N 1/36085 Eating disorders or obesity
• CPC Class Codes: A61N 1/36117 for treating hypertension
• CPC Class Codes: A61N 1/36139 with automatic adjustment
• CPC Class Codes: A61N 1/36164 Sub-threshold or non-excitatory signals non-excitatory signals to the heart A61N1/3628

Abstract

There is provided in accordance with an exemplary embodiment of the invention a method of treating diabetic patients comprising measuring a triglyceride level in a diabetic patient and applying a diabetes treatment according to the triglyceride level. Optionally, there is provided a method of screening. Alternatively or additionally, there is provided a method of weight loss. Alternatively or additionally, there is provided a method of relatively reducing HOMA-IR levels. Alternatively or additionally, there is provided a method of relatively reducing blood pressure. An exemplary device to apply the treatment is described.

Claims

1. A method of treating a patient for diabetes, comprising:

selecting a treatment for a patient with diabetes;

modifying the treatment according to a lipid level or a lipid indicator of said patient; and

applying said modified treatment to said patient.

2. A method according to claim 1, wherein said lipid level comprises a plasma level.

3. A method according to claim 1, wherein said lipid level comprises a hepatic level.

4. A method according to claim 1, comprising estimating the lipid level.

5. A method according to claim 1, wherein modifying the treatment comprises changing a timing of application of said treatment according to an expected change in lipid level.

6. A method according to claim 1, wherein modifying the treatment comprises selecting a treatment type or one or more treatment parameters according to said lipid level.

7. A method according to claim 1, wherein modifying the treatment comprises taking into account said lipid level when planning power usage.

8. A method according to claim 1, wherein modifying the treatment comprises generating at least an indication to a patient to delay an activity and thereby allow the treatment to be applied at a lower lipid level.

9. A method according to claim 1, wherein modifying the treatment comprises selecting a treatment parameter such that it overcomes or bypasses a control pathway blockage associated with said lipid.

10. A method according to claim 1, wherein modifying the treatment comprises applying an additional treatment to reduce said lipid level or overcome a control-effect of said lipid level.

11. A method according to claim 1, wherein said lipid level comprises an absolute lipid level.

12. A method according to claim 1, wherein said lipid level comprises a relative lipid level.

13. A method according to claim 1, wherein said lipid level comprises a change in lipid level.

14. A method according to claim 13, wherein said change in lipid level comprises a reduction in triglycerides.

20. A method according to claim 1, wherein said lipid comprises triglycerides.

21. A method according to claim 1, wherein said selecting a treatment comprises selecting a treatment for reducing blood glucose levels.

15. A method of treating a patient for diabetes, comprising modifying a lipid level of said patient according to a treatment to be applied.

16. A method according to claim 15, wherein said modifying comprises modifying using a pharmaceutical.

17. A method according to claim 15, wherein said modifying comprises modifying using electrical stimulation of an intrabody location.

18. A method according to claim 17, comprising using a same set of electrodes for said treatment and for said modifying.

19. A method according to claim 17, wherein modifying the treatment comprises taking into account said lipid level when planning power usage for said electrical stimulation.

22. A method of treating a patient for diabetes, comprising:

determining a treatment to be applied to a patient with diabetes;

identifying a control pathway in the patient which interacts with said treatment;

modifying said control pathway of said patient according to said treatment to be applied; and

applying said treatment for said patient in addition to said modifying.

23. A method according to claim 22, wherein said modifying comprises stimulating a vagal nerve.

24. A method according to claim 22, wherein said modifying comprises modifying one or more parameter of said treatment so as to overcome a blockage in said pathway.

25. A method according to claim 22, wherein said modifying comprises stimulating upstream of said blockage.

26. A method according to claim 22, wherein said modifying comprises interfering with an input to said pathway.

27. A method according to claim 22, wherein said modifying comprises perturbating said pathway.

28. A method according to claim 22, wherein said modifying comprises causing reduction in triglyceride levels;

and wherein said applying comprises applying said treatment after said reduction is achieved and with at least one parameter selected based on said reduction.

29. A method according to claim 28, wherein said modifying comprises modifying by pharmaceutical and wherein said applying comprises electrically applying.

30. A method according to claim 22, wherein said treatment comprises application of an electrical field to a part of the body.

31. A method according to claim 22, wherein said treatment comprises application of an electrical field to a part of the GI tract.

32. A method according to claim 22, wherein said treatment comprises pharmaceutical treatment.

33. A method of treating a patient for diabetes, comprising:

determining a treatment to be applied to a patient with diabetes;

identifying a control pathway in the patient having a blockage which interferes with said treatment;

selecting one or more treatment parameters to overcome said blockage; and

applying said treatment for said patient using said selected one or more parameters.

34. A method according to claim 33, wherein identifying a pathway comprises identifying a pathway affected by a lipid.

35. A method according to claim 33, wherein identifying a pathway comprises identifying a pathway affected by triglycerides.

36. A method according to claim 33, wherein said treatment comprises application of an electrical field to a part of the body.

37. A method of treating a patient for diabetes, comprising:

selecting a treatment and at least one treatment parameter for a patient with diabetes according to a lipid level or a lipid indicator of said patient; and

applying said treatment with said at least one parameter to said patient.

38. A method according to claim 37, wherein said lipid is one or more of triglycerides, HDL and LDL.

39. A method according to claim 38, wherein said lipid comprises triglycerides.

40. A method according to claim 37, wherein said treatment comprises application of an electrical field to a part of the body.