Amyloid-beta binding proteins
First Claim
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1. An antibody or antigen binding fragment thereof comprising a set of six CDRs comprising SEQ ID NOs:
- 17, 18, 19, 20, 21 and 22;
or a set of six CDRs comprising SEQ ID NOs;
33, 34, 35, 36, 37 and 38, wherein said antibody or antigen binding fragment specifically binds to amyloid-beta (20-42) globulomer.
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Abstract
The present invention relates to amyloid-beta (Aβ) binding proteins. Antibodies of the invention have high affinity to Aβ(20-42) globulomer or any Aβ form that comprises the globulomer epitope. Method of making and method of using the antibodies of the invention are also provided.
405 Citations
43 Claims
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1. An antibody or antigen binding fragment thereof comprising a set of six CDRs comprising SEQ ID NOs:
- 17, 18, 19, 20, 21 and 22;
or a set of six CDRs comprising SEQ ID NOs;
33, 34, 35, 36, 37 and 38, wherein said antibody or antigen binding fragment specifically binds to amyloid-beta (20-42) globulomer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43)
- 17, 18, 19, 20, 21 and 22;
Specification