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Generation of human;pIX phage display libraries

  • US 9,062,305 B2
  • Filed: 08/25/2009
  • Issued: 06/23/2015
  • Est. Priority Date: 12/19/2007
  • Status: Expired due to Fees
First Claim
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1. A method for screening a phage library for Fab antibody fragments having a desired biological activity, comprising (a) expressing Fab antibody fragments in said phage library wherein said fragments are expressed in bacterial host cells, and where said host cells comprise a recombinant nucleic acid phage vector comprising the sequence of SEQ ID NO:

  • 79, and nucleic acid sequences encoding a phage pIX protein fused to a Fab amino acid sequence, wherein said Fab amino acid sequence binds to an antigen and (b) selecting bacterial cells expressing said Fab antibody fragments having said desired biological activity.

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