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Multiple sclerosis therapeutic methods using therapeutic delivery devices and systems

  • US 9,066,685 B2
  • Filed: 12/29/2011
  • Issued: 06/30/2015
  • Est. Priority Date: 12/31/2010
  • Status: Active Grant
First Claim
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1. A method of treating multiple sclerosis, comprising:

  • providing a treatment device comprising a therapy agent delivery catheter capable of applying a therapeutic agent to a lesion of a vein through the therapy agent delivery catheter to dissolve fibrin or thrombus present at or causing the lesion or otherwise treat the lesion, the therapy agent delivery catheter including an intravascular ultrasound (IVUS) component adjacent to a therapeutic delivery component, wherein the IVUS component is configured to image the vein and wherein the therapeutic delivery component is configured to apply the therapeutic agent to the lesion of the vein;

    identifying at least one venous outflow obstruction site of a patient based on images obtained from the IVUS component of the therapy agent delivery catheter;

    assessing the at least one venous outflow obstruction site to determine whether the at least one venous outflow obstruction site causes significant narrowing of the vein, wherein venous outflow obstruction sites causing significant narrowing of the vein are identified for treatment with the therapeutic agent via the therapeutic delivery component of the therapy agent delivery catheter;

    verifying the at least one venous outflow obstruction site by determining a pressure gradient across the at least one venous outflow obstruction site, the pressure gradient being calculated as a ratio of a pressure distal to the at least one venous outflow obstruction site and a pressure in the superior vena cava; and

    applying the treatment device to an identified venous outflow obstruction site of the vein to treat multiple sclerosis symptoms of the patient, including applying the therapeutic agent to the identified venous outflow obstruction site to increase a cross-sectional area of a lumen of the vein.

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