Delivering ocular implants into the eye

• US 9,066,750 B2
• Filed: 01/02/2014
• Issued: 06/30/2015
• Est. Priority Date: 12/19/2011
• Status: Active Grant

• Current Assignee: Alcon Incorporated
• Original Assignee: Ivantis Inc.
• Inventors: Wardle, John, Schieber, Andrew T.
• Primary Examiner(s): Wiest, Philip R
• Assistant Examiner(s): Zimbouski, Ariana
• Application Number:
  US14/146,587
• Publication Number:
  US 20140121584A1
• Time in Patent Office: 544 Days
• Field of Search: 604/8, 604/9, 606/107, 606/108, 623 111- 112, 623/1.23, 600184-190
• US Class Current: 1/1
• CPC Class Codes: A61B 17/3421 Cannulas
• CPC Class Codes: A61B 17/3468 for implanting or removing devices, e.g. prostheses, implants, seeds, wires devices for implanting seeds A61M37/0069
• CPC Class Codes: A61B 2017/3454 Details of tips
• CPC Class Codes: A61F 2220/0033 made by longitudinally pushing a protrusion into a complementary-shaped recess, e.g. held by friction fit
• CPC Class Codes: A61F 9/0017 implantable in, or in contact with, the eye, e.g. ocular inserts
• CPC Class Codes: A61F 9/0026 Ophthalmic product dispenser attachments to facilitate positioning near the eye
• CPC Class Codes: A61F 9/00781 Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment drainage implants in general A61M27/002

Abstract

A method of deploying an ocular implant into Schlemm'"'"'s canal of an eye. The method includes the steps of inserting a distal end of a cannula through a cornea of the eye and into an anterior chamber of the eye, the cannula having a distal opening extending from the distal end and through a side wall; placing the distal opening of the cannula into fluid communication with Schlemm'"'"'s canal; advancing the ocular implant distally through the cannula with a delivery tool engaged with the ocular implant, a proximal portion of the ocular implant engaging the delivery tool proximal to a distal portion of the delivery tool; and disengaging the ocular implant and the delivery tool when the proximal portion of the ocular implant reaches the cannula distal opening. The invention also includes a system for practicing the method.

Claims

1. A method of deploying an ocular implant into Schlemm'"'"'s canal of an eye, comprising:

inserting a distal end of a curved distal portion of a cannula having a radius of curvature through a cornea of the eye and into an anterior chamber of the eye, the cannula comprising a distal opening with a trough extending from the distal end and through a side wall;

placing the distal opening of the cannula into fluid communication with Schlemm'"'"'s canal;

advancing the ocular implant distally through the cannula with a delivery tool engaged with the ocular implant, a proximal interlocking portion of the ocular implant engaging a complimentary interlocking portion of the delivery tool proximal to the distal opening of the cannula, the delivery tool having a curved at-rest shape with a smaller radius of curvature than the radius of curvature of the curved distal portion of the cannula; and

disengaging the ocular implant and the delivery tool when the proximal interlocking portion of the ocular implant reaches the cannula distal opening by permitting the delivery tool to move toward its curved at-rest shape.

2. The method of claim 1, wherein the disengaging step comprises separating the distal portion of the delivery tool and the ocular implant from each other when the distal portion of the delivery tool passes through the distal opening of the cannula.

3. The method of claim 1, wherein the disengaging step comprises separating the distal portion of the delivery tool and the ocular implant from each other before the distal portion of the delivery tool reaches the distal end of the cannula.

4. The method of claim 2 wherein the separating step comprises maintaining contact between the ocular implant and the cannula and moving the distal portion of the delivery tool away from the cannula.

5. The method of claim 1, wherein the inserting step comprises placing the distal end of the cannula in Schlemm'"'"'s canal and a portion of the cannula distal opening outside of Schlemm'"'"'s canal, the disengaging step comprising disengaging the ocular implant and the delivery tool while the proximal portion of the ocular implant is disposed outside of Schlemm'"'"'s canal.

6. The method of claim 5, wherein the disengaging step further comprises disengaging the ocular implant and the delivery tool while the proximal portion of the ocular implant is disposed inside the anterior chamber of the eye.

7. The method of claim 1, further comprising, after the disengaging step:

re-engaging the delivery tool and the ocular implant;

moving the delivery tool and the ocular implant in a proximal direction to withdraw at least a portion of the ocular implant from Schlemm'"'"'s canal;

advancing the ocular implant and delivery tool distally into Schlemm'"'"'s canal; and

disengaging the ocular implant and the delivery tool.

8. The method of claim 1, wherein the disengaging step comprises disengaging an interlocking portion of the delivery tool from a complementary interlocking portion of the ocular implant.

9. The method of claim 1, wherein the side wall of the cannula prevents the complimentary interlocking portion of the delivery tool from assuming its curved at rest shape when the complimentary interlocking portion of the delivery tool is proximal to the cannula distal opening.