Methods and apparatus for treating glaucoma

• US 9,066,783 B2
• Filed: 08/15/2013
• Issued: 06/30/2015
• Est. Priority Date: 03/05/2008
• Status: Active Grant

• Current Assignee: Alcon Incorporated
• Original Assignee: Ivantis Inc. (Alcon Incorporated)
• Inventors: Euteneuer, Charles L., Hektner, Thomas R., Schieber, Andrew T., Wardle, John
• Primary Examiner(s): MARCETICH, ADAM M
• Application Number:
  US13/968,051
• Publication Number:
  US 20130331761A1
• Time in Patent Office: 684 Days
• Field of Search: 604/8, 604/9, 604/264, 604/27, 604/272, 604/28, 604/48, 604/500, 604/540, 604/541, 604/93.01, 606/108, 623/4.1, 623/6.64
• US Class Current: 1/1
• CPC Class Codes: A61F 2009/00885 for treating a particular disease
• CPC Class Codes: A61F 2009/00891 Glaucoma
• CPC Class Codes: A61F 9/0017 implantable in, or in contact with, the eye, e.g. ocular inserts
• CPC Class Codes: A61F 9/007 Methods or devices for eye surgery
• CPC Class Codes: A61F 9/00781 Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment drainage implants in general A61M27/002
• CPC Class Codes: A61K 9/0051 Ocular inserts, ocular implants
• CPC Class Codes: A61M 2210/0612 Eyes
• CPC Class Codes: A61M 27/002 Implant devices for drainage of body fluids from one part of the body to another intraocular A61F9/00781; middle ear A61F11/202
• CPC Class Codes: Y10S 623/905 Eye
• CPC Class Codes: Y10S 623/906 Corneal

Abstract

An ocular implant for treating glaucoma is provided, which may include any number of features. More particularly, the present invention relates to implants that facilitate the transfer of fluid from within one area of the eye to another area of the eye. One feature of the implant is that it includes a proximal inlet portion and a distal inlet portion adapted to be inserted into the anterior chamber of the eye, and an intermediate portion adapted to be inserted into Schlemm'"'"'s canal. Another feature of the implant is that it can be biased to assume a predetermined shape to aid in placement within the eye.

Claims

1. An ocular implant defining a generally cylindrical volume, comprising:

a proximal inlet portion at a proximal end of the implant adapted to be positioned in an anterior chamber of an eye;

a distal inlet portion at a distal end of the implant, the distal inlet portion being biased to bend at a first radius of curvature in a first plane;

an intermediate portion positioned between the proximal inlet portion and the distal inlet portion, the intermediate portion being biased to bend at a second radius of curvature in the first plane; and

a plurality of openings in the implant to facilitate fluidic flow laterally across the elongate implant.

2. The implant of claim 1 wherein the implant defines a lumen to facilitate fluidic flow longitudinally along the implant.

3. The implant of claim 1 wherein the first radius of curvature is smaller than the second radius of curvature.

4. The implant of claim 1 wherein the second radius of curvature approximates the curvature of Schlemm'"'"'s canal.

5. The implant of claim 1 wherein the proximal portion is biased to bend at a third radius of curvature.

6. The implant of claim 5 wherein the third radius of curvature is generally smaller than the second radius of curvature.

7. The implant of claim 5 wherein the third radius of curvature is generally equal to the first radius of curvature.

8. The implant of claim 1 wherein the plurality of openings extend over more than about 50% of an outer surface area of the implant.

9. An ocular implant defining a generally cylindrical volume, comprising:

a proximal inlet portion at a proximal end of the implant, the proximal inlet portion adapted to be positioned in an anterior chamber of the eye;

a distal inlet portion at a distal end of the implant, the distal inlet portion adapted to be positioned in the anterior chamber of the eye, the distal inlet portion being biased to bend at a first radius of curvature in a first plane;

an intermediate portion positioned between the proximal and distal inlet portions, the intermediate portion adapted to be positioned in Schlemm'"'"'s canal, the intermediate portion being biased to bend at a second radius of curvature in the first plane; and

a plurality of openings in the implant to facilitate fluidic flow laterally across the implant.

10. The implant of claim 9 wherein the implant defines a lumen to facilitate fluidic flow longitudinally along the implant.

11. An ocular implant, comprising:

a proximal locking portion at a proximal end of the implant, the proximal end of the implant including a proximal inlet portion adapted to be positioned in an anterior chamber of an eye;

a distal locking portion at a distal end of the implant;

an intermediate portion extending between the proximal locking portion and the distal locking portion;

the intermediate portion having a longitudinal axis that follows an arcuate path in a first plane when the implant is assuming a relaxed shape;

wherein the proximal locking portion is biased to extend in a first radially inward direction relative to the arcuate path of the longitudinal axis of the intermediate portion; and

wherein the distal locking portion is biased to extend in a second radially inward direction in the first plane relative to the arcuate path of the longitudinal axis of the intermediate portion.

12. The implant of claim 11 wherein the first radially inward direction and the second radially inward direction both lead out of Schlemm'"'"'s canal of an eye when the intermediate portion of the implant is disposed in Schlemm'"'"'s canal of the eye.

13. The implant of claim 11 wherein the implant is dimensioned so that the proximal locking portion and the distal locking portion will both extend through a wall of Schlemm'"'"'s canal of an eye when the intermediate portion of the implant is disposed in Schlemm'"'"'s canal of the eye.

14. The implant of claim 11 wherein the likelihood that the intermediate portion of the implant will migrate within Schlemm'"'"'s canal of an eye is reduced when the proximal locking portion and the distal locking portion both extend through a wall of Schlemm'"'"'s canal.

15. The implant of claim 11 wherein the first radially inward direction and the second radially inward direction both lead out of Schlemm'"'"'s canal of an eye when the longitudinal axis of the intermediate portion is coaxial with a longitudinal axis of Schlemm'"'"'s canal.

16. The implant of claim 11 wherein a radius of curvature of the longitudinal axis of the intermediate portion approximates the curvature of Schlemm'"'"'s canal when the implant is assuming the relaxed shape.

17. The implant of claim 11 wherein a wall of the implant defines a plurality of openings in the implant to facilitate fluidic flow laterally across the implant.

18. The implant of claim 11 wherein the implant defines a lumen to facilitate fluidic flow longitudinally along the implant.