Bezoar-forming units for weight control
First Claim
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1. A bezoar-forming unit for forming at least one temporary bezoar in a gastrointestinal organ of an animal, including a mammal, to fill a space in the organ, the bezoar-forming unit comprising:
- (a) at least one ingestible disintegrable capsule configured to disintegrate within the gastrointestinal organ subsequent to ingestion of said at least one ingestible disintegrable capsule;
(b) a plurality of fibers stored in a folded condition within the at least one ingestible disintegrable capsule in an untangled state with one another, the plurality of fibers being of sufficient length to become entangled with one another when released from the folded condition, whereby post-ingestion disintegration of said at least one ingestible capsule results in releasing of the plurality fibers from the ingestible capsule, unfolding of the plurality of fibers into larger dimensions within the gastrointestinal organ, and in situ tangling between said released and unfolded plurality of fibers due to natural spontaneously existing motility of the gastrointestinal organ, thereby causing in situ formation of at least one temporary bezoar through said tangling; and
(c) a mechanism to disintegrate the at least one temporary bezoar after a predetermined amount of time.
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Abstract
Bezoar-forming units for forming at least one temporary bezoar in a gastrointestinal organ of an animal, including a mammal, to fill a space in the said organ, are provided for weight control. The units include biodegradable fiber-based configurations of various length and shape having a first dimension and a second dimension; whereby when the bezoar-forming units are located in the given gastrointestinal organ, at least one temporary, permeable bezoar is formed.
40 Citations
12 Claims
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1. A bezoar-forming unit for forming at least one temporary bezoar in a gastrointestinal organ of an animal, including a mammal, to fill a space in the organ, the bezoar-forming unit comprising:
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(a) at least one ingestible disintegrable capsule configured to disintegrate within the gastrointestinal organ subsequent to ingestion of said at least one ingestible disintegrable capsule; (b) a plurality of fibers stored in a folded condition within the at least one ingestible disintegrable capsule in an untangled state with one another, the plurality of fibers being of sufficient length to become entangled with one another when released from the folded condition, whereby post-ingestion disintegration of said at least one ingestible capsule results in releasing of the plurality fibers from the ingestible capsule, unfolding of the plurality of fibers into larger dimensions within the gastrointestinal organ, and in situ tangling between said released and unfolded plurality of fibers due to natural spontaneously existing motility of the gastrointestinal organ, thereby causing in situ formation of at least one temporary bezoar through said tangling; and (c) a mechanism to disintegrate the at least one temporary bezoar after a predetermined amount of time. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A method for forming a temporary bezoar in a gastrointestinal organ of an animal, including a mammal, comprising:
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administering to the animal or mammal at least one ingestible disintegrable capsule containing a plurality of fibers in a folded condition and an untangled state with one another, the plurality of fibers being of sufficient length to become entangled with one another when released from the folded condition, whereupon each of the plurality of fibers unfolds from a first dimension to a larger second dimension; and allowing the at least one ingestible disintegrable capsule to disintegrate within the targeted gastrointestinal organ and release the plurality of fibers from the folded condition, thereby allowing unfolding of the plurality of fibers from the first dimension to the larger second dimension; and allowing entangling of the released, unfolded plurality of fibers with one another within the targeted gastrointestinal organ as a result of spontaneously existing motility of the targeted gastrointestinal organ; wherein the in-situ tangling of the said plurality of fibers forms at least one temporary bezoar of sufficient dimensions that preclude said at least one temporary bezoar from exiting the targeted gastrointestinal organ. - View Dependent Claims (9, 10, 11)
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12. A bezoar-forming unit for forming at least one temporary bezoar in a gastrointestinal organ of an animal, including a mammal, to fill a space in the organ, the bezoar-forming unit comprising:
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(a) at least one ingestible disintegrable capsule configured to disintegrate within the gastrointestinal organ subsequent to ingestion of said at least one ingestible disintegrable capsule;
said ingestible disintegrable capsule encapsulating a permeable saclike member;
wherein said saclike member contains a plurality of swellable polymers and has radial outwardly-pointing fibers attached to an outer surface of the saclike member;(b) upon administration in a given gastrointestinal organ, the capsule dissolves and the saclike member expands to a second dimension;
the radial fibers are unfolded and untangled;(c) after a predetermined amount of time, the second dimension of the saclike member forms a bezoar in a third dimension;
wherein the fibers are formed around the swellable polymer and entangled with one another in the third dimension.
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Specification