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Dose selection of adjuvanted synthetic nanocarriers

  • US 9,066,978 B2
  • Filed: 05/26/2011
  • Issued: 06/30/2015
  • Est. Priority Date: 05/26/2010
  • Status: Active Grant
First Claim
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1. A method for increasing local immune cytokine induction but not systemic induction of pro-inflammatory cytokines comprising:

  • generating a systemic cytokine release through administration to a subject of a dose of an adjuvant, wherein at least a portion of the dose of the adjuvant is coupled to synthetic nanocarriers andchoosing the dose of the coupled adjuvant to be greater than a separate dose of the adjuvant which is not coupled to synthetic nanocarriers, wherein the administration of the coupled adjuvant results in a systemic cytokine release similar to that generated through administration of the dose of the not-coupled adjuvant to the subject.

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