Method to control the biodegradation rates of polymer structures
First Claim
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1. A method for selectively degrading a three-dimensional biological scaffold, comprising:
- providing a three-dimensional biodegradable biological scaffold in an aqueous medium, wherein the scaffold is comprised of a polymer;
subjecting the scaffold to a treatment capable of selectively degrading the polymer, the treatment selected from the group consisting of base, acid, oxidation, heat and combinations thereof, wherein the treatment includes an effective amount of base, acid, oxidant, heat or combinations thereof that is capable of partially degrading the polymer, wherein the effective amount of heat includes temperatures between about 80°
C. to about 250°
C.; and
incubating the scaffold under conditions which create a partially degraded three-dimensional biodegradable biocompatible biological scaffold;
wherein the three-dimensional biodegradable biocompatible biological scaffold is a three-dimensional ordered open-cellular polymer structure which (i) is formed by a plurality of polymer waveguides which interpenetrate each other at a plurality of nodes and (ii) has a micro-truss architecture comprising a repeating pattern of ordered interconnected pores;
wherein the three-dimensional ordered open-cellular polymer structure is made by photopolymerization of a monomer composition, the monomer composition comprising;
a first molecule comprising at least one C═
C double bond or C≡
C triple bond;
a second molecule having the structure R—
X1—
H, wherein X1 is one of O, S, or N; and
a photoinitiator.
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Abstract
Methods to selectively control the bio-degradation rates of biologically compatible microstructures and methods to control the bio-degradation rates of three-dimensional biological scaffolds, such as ordered open-cellular polymer structures used as biological growth templates are disclosed. Medical uses and application of these materials are disclosed.
6 Citations
19 Claims
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1. A method for selectively degrading a three-dimensional biological scaffold, comprising:
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providing a three-dimensional biodegradable biological scaffold in an aqueous medium, wherein the scaffold is comprised of a polymer; subjecting the scaffold to a treatment capable of selectively degrading the polymer, the treatment selected from the group consisting of base, acid, oxidation, heat and combinations thereof, wherein the treatment includes an effective amount of base, acid, oxidant, heat or combinations thereof that is capable of partially degrading the polymer, wherein the effective amount of heat includes temperatures between about 80°
C. to about 250°
C.; andincubating the scaffold under conditions which create a partially degraded three-dimensional biodegradable biocompatible biological scaffold; wherein the three-dimensional biodegradable biocompatible biological scaffold is a three-dimensional ordered open-cellular polymer structure which (i) is formed by a plurality of polymer waveguides which interpenetrate each other at a plurality of nodes and (ii) has a micro-truss architecture comprising a repeating pattern of ordered interconnected pores; wherein the three-dimensional ordered open-cellular polymer structure is made by photopolymerization of a monomer composition, the monomer composition comprising; a first molecule comprising at least one C═
C double bond or C≡
C triple bond;a second molecule having the structure R—
X1—
H, wherein X1 is one of O, S, or N; anda photoinitiator. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A method for selectively degrading a three-dimensional biodegradable biological scaffold having an ordered open-cellular polymer structure, comprising:
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providing a three-dimensional biodegradable biological scaffold having an ordered open-cellular polymer structure made by photopolymerization of monomer composition, the monomer composition comprising a first molecule comprising at least one C═
C double bond or C≡
C triple bond, a second molecule having a structure of R—
X1—
H, wherein X1 is one of O, S, or N, and a photoinitiator, wherein the three-dimensional ordered open-cellular polymer structure;
(i) is in an aqueous medium, (ii) is formed by a plurality of self-propagating polymer waveguides which interpenetrate each other at a plurality of nodes, and (iii) has a micro-truss architecture comprising a repeating pattern of ordered interconnected pores;subjecting the scaffold to a treatment capable of selectively degrading the three-dimensional biological scaffold, the treatment selected from the group consisting of base, acid, oxidation, heat and combinations thereof wherein the treatment includes an effective amount of base, acid, oxidant, heat or combinations thereof being capable of partially degrading the polymer, wherein the effective amount of base is selected from the group consisting of sodium hydroxide, potassium hydroxide, lithium hydroxide, sodium carbonate, potassium carbonate, lithium carbonate, barium hydroxide, cesium hydroxide, strontium hydroxide, calcium hydroxide, pyridine, ammonia, and mixtures thereof, wherein the effective amount of acid is selected from the a group consisting of hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, acetic acid and mixtures thereof, and wherein the effective amount of oxidant is selected from the group consisting of potassium permanganate, potassium dichromate, ozone, hydrogen peroxide, chlorite, hypochlorite, chlorate, nitric acid, pyridinium chlorochromate, osmium tetraoxide, persulfuric acid or salts, cerium (IV) salts, and mixtures thereof, and wherein the effective amount of heat includes temperatures from about 80°
C. to about 250°
C.; andincubating the scaffold under conditions sufficient to selectively degrade the polymer to create a partially degraded three-dimensional biodegradable biocompatible biological scaffold.
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19. A medical implant device made by a method of selectively degrading a three-dimensional biological scaffold, the method comprising the steps of:
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providing a three-dimensional biodegradable biological scaffold in an aqueous medium, wherein the scaffold is a polymer structure; subjecting the three-dimensional biological polymer scaffold to a treatment capable of selectively degrading the polymer, the treatment selected from the group consisting of base, acid, oxidation, heat and combinations thereof, wherein the treatment includes an effective amount of base, acid, oxidant, heat or combinations thereof that is capable of partially degrading the polymer, wherein the effective amount of heat includes temperatures between about 80°
C. to about 250°
C.; andincubating the scaffold under conditions which create a partially degraded biodegradable biocompatible biological scaffold, wherein the three-dimensional biodegradable biocompatible biological scaffold has a three-dimensional ordered open-cellular polymer structure which (i) is formed by a plurality of self-propagating polymer waveguides which interpenetrate each other at a plurality of nodes and (ii) has a micro-truss architecture comprising a repeating pattern of ordered interconnected pores, wherein the three-dimensional ordered open-cellular polymer structure is made by photopolymerization of a monomer composition, the monomer composition comprising; a first molecule comprising at least one C═
C double bond or C≡
C triple bond;a second molecule having a structure of R—
X1—
H, wherein X1 is one of O, S, or N; anda photoinitiator.
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Specification