End-capped poly(ester amide) copolymers

• US 9,067,000 B2
• Filed: 11/18/2013
• Issued: 06/30/2015
• Est. Priority Date: 10/27/2004
• Status: Expired due to Fees

• Current Assignee: Abbott Cardiovascular Systems Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Abbott Cardiovascular Systems Incorporated (Abbott Laboratories Incorporated)
• Inventors: DesNoyer, Jessica Renee, Pacetti, Stephen Dirk, Nayak, Vidya, Kleiner, Lothar
• Primary Examiner(s): Woodward, Ana
• Application Number:
  US14/083,226
• Publication Number:
  US 20140107148A1
• Time in Patent Office: 589 Days
• Field of Search: 424/78, 424/37, 424/422, 424/423, 424/426, 424/486, 428/423.1, 428/474.4, 525/420, 525/434, 528/288, 528/302, 528/307, 528/308, 528/323, 528/324, 528/325, 528/326, 528/329.1, 528/330, 528/331, 528/332, 528/335, 604/48, 604/500, 604/890.1, 623/1.1
• US Class Current: 1/1
• CPC Class Codes: A61L 2300/416 Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 31/041 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 31/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system
• CPC Class Codes: C08G 69/44 Polyester-amides
• CPC Class Codes: C08G 69/48 Polymers modified by chemical after-treatment
• CPC Class Codes: C08L 77/12 Polyester-amides
• CPC Class Codes: Y10T 428/31551 Of polyamidoester [polyurethane, polyisocyanate, polycarbamate, etc.]
• CPC Class Codes: Y10T 428/31725 Of polyamide

Abstract

This invention relates to poly(ester amide)s (PEAs) comprising inactivated terminal amino and carboxyl groups, methods of synthesizing the inactivated PEAs and uses for them in the treatment of vascular diseases.

Claims

1. A polymer of formula:

PEA-Inactivated Terminal Amino Group

or

Inactivated Terminal Carboxyl Group-PEA;

wherein PEA comprises formula I;

2. A coating for an implantable medical device comprising the polymer of claim 1.

3. The coating of claim 2, wherein the implantable medical device is a stent.