Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly

• US 9,067,004 B2
• Filed: 03/28/2012
• Issued: 06/30/2015
• Est. Priority Date: 03/28/2011
• Status: Active Grant

• Current Assignee: New Health Sciences, Inc.
• Original Assignee: New Health Sciences, Inc.
• Inventors: Yoshida, Tatsuro, Vernucci, Paul
• Primary Examiner(s): Zalukaeva, Tatyana
• Assistant Examiner(s): SASS, SARA A
• Application Number:
  US13/432,810
• Publication Number:
  US 20130259744A1
• Time in Patent Office: 1,189 Days
• US Class Current: 1/1
• CPC Class Codes: A61M 1/0272 Apparatus for treatment of blood or blood constituents prior to or for conservation, e.g. freezing, drying or centrifuging
• CPC Class Codes: A61M 1/0281 Apparatus for treatment of blood or blood constituents prior to transfusion, e.g. washing, filtering or thawing
• CPC Class Codes: A61M 1/38 Removing constituents from donor blood and storing or returning remainder to body , e.g. for transfusion
• CPC Class Codes: A61M 2202/0208 Oxygen
• CPC Class Codes: A61M 2202/0225 Carbon oxides, e.g. Carbon dioxide
• CPC Class Codes: A61M 2202/0439 White blood cells; Leucocytes lymphocytes A61M2202/0407

Abstract

A portable assembly for processing red blood cells RBCs including a disposable blood collection set including a blood bag, an anaerobic storage bag and an oxygen and/or oxygen and carbon dioxide depletion device disposed between the blood collection bag and anaerobic storage bag. The portable assembly further provides for a gas circulation device in fluid communication with the oxygen or oxygen and carbon dioxide depletion device. The gas circulation device includes a pressure source that is able circulate flushing gas through the depletion device as RBCs pass from the blood collection bag, through the depletion device and into the anaerobic storage bag.

Claims

1. A portable system for processing red blood cells (RBCs) comprising:

a gas circulation device providing a flushing gas capable of being placed in fluid communication with one or more oxygen or oxygen and carbon dioxide depletion devices,

said gas circulation device comprising, in fluid communication with each other;

a flushing gas source;

a gas outlet manifold;

a first gas sterilization filter;

a second gas sterilization filter;

one or more gas sensor assemblies;

a gas inlet manifold; and

a controller,

wherein at least one of said one or more gas sensor assemblies is selected from the group consisting of an oxygen sensor, a carbon dioxide sensor, and a combination thereof, and said gas sensor assemblies comprise a partial pressure sensor.

2. The portable system according to claim 1, further comprising a housing containing said gas circulation device, wherein said housing further comprises a sorbent disposed between said flushing gas source and said gas outlet manifold for removing oxygen and/or oxygen and carbon dioxide from said flushing gas.

3. The portable system according to claim 2, wherein said one or more gas sensor assemblies comprise a first gas sensor assembly comprising a first partial pressure sensor disposed between said flushing gas source and said sorbent and a second gas sensor assembly comprising a second partial pressure sensor disposed between said sorbent and said gas outlet manifold, wherein said gas sensor assemblies detect a level of oxygen or carbon dioxide in said flushing gas.

4. The portable system according to claim 1, further comprising one or more load cells and one or more flow regulator valves in communication with said controller, wherein said one or more flow regulators are configured to control the flow of RBCs through said one or more oxygen or oxygen and carbon dioxide depletion devices and said one or more load cells are configured to measure the load of RBCs collected in an anaerobic storage bag.

5. The portable system according to claim 4, wherein said controller communicates a signal to restrict or facilitate a flow of RBCs through said one or more flow regulator valves in response to a signal from said one or more load cells.

6. The portable system according to claim 4, further comprising an oxygen saturation sensor capable of measuring the level of oxygen saturation in RBCs flowing through said one or more oxygen or oxygen and carbon dioxide depletion devices and in communication with said controller, wherein said controller communicates a signal to said one or more flow regulator valves to restrict or facilitate the flow of RBCs through said one or more flow regulator valves.

7. The portable system according to claim 1, wherein said flushing gas comprises Ar, He, N₂, Ar/CO₂, He/CO₂ or N₂/CO₂, or any combination of inert gasses and/or CO₂.

8. The portable system according to claim 1, wherein said flushing gas source is selected from the group consisting of a pump, a vacuum or a pressurized container.

9. The portable system according to claim 1, wherein said one or more gas sensor assemblies further comprise temperature, gas flow rate, total pressure and humidity detectors.