Magnetic configuration and timing scheme for transcranial magnetic stimulation

• US 9,067,052 B2
• Filed: 03/02/2010
• Issued: 06/30/2015
• Est. Priority Date: 03/02/2009
• Status: Active Grant

• Current Assignee: Yeda Research and Development Co. Ltd. (Weizmann Institute of Science)
• Original Assignee: Yeda Research and Development Co. Ltd. (Weizmann Institute of Science)
• Inventors: Moses, Elisha, Rotem, Assaf
• Primary Examiner(s): Koharski, Christopher D
• Assistant Examiner(s): EDWARDS, PHILIP CHARLES
• Application Number:
  US13/254,361
• Publication Number:
  US 20120053449A1
• Time in Patent Office: 1,946 Days
• Field of Search: 607/14, 607/13, 607/9, 600/14, 600/13, 600/9
• US Class Current: 1/1
• CPC Class Codes: A61B 5/0036 including treatment, e.g., using an implantable medical device, ablating, ventilating
• CPC Class Codes: A61N 1/36025 for treating a mental or cerebral condition
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
• CPC Class Codes: A61N 1/40 Applying electric fields by inductive or capacitive coupling microwave apparatus A61N5/00; Applying radio-frequency signals
• CPC Class Codes: A61N 2/006 for magnetic stimulation of nerve tissue
• CPC Class Codes: A61N 2/02 using magnetic fields produced by coils, including single turn loops or electromagnets A61N2/12 takes precedence

Abstract

Transcranial magnetic stimulation (TMS) is a remarkable tool for probing the brain. However, it is still unclear why specific regions in the cortex are excitable by TMS while others are not. This invention provides methods and tools for the design of efficient magnetic stimulators. Such stimulators can excite neuronal networks that were not sensitive to stimulation until now. Stimulation can be carried out both in-vitro and in-vivo. Novel systems and techniques of this invention will enable both treatment and diagnostics by stimulating regions of the brain or neuronal assemblies that were previously unaffected by TMS.

Claims

1. A method for improved neuron excitation, said method comprising subjecting one or more neurons to a rotating electric field, thereby exciting said neuron or said neurons, wherein the rotation of said rotating electric field is the result of vector summation of at least two time-dependent electric fields that are induced by at least two time-dependent magnetic field pulses, said pulses at least partially overlap in time.

2. The method of claim 1, wherein said at least two time-dependent magnetic fields are induced by passing currents through at least two separate and independent coils.

3. The method of claim 2, wherein said two separate and independent coils are driven with shifted phases in time of said currents.

4. The method of claim 3, wherein said coils create said at least two time-dependent electric fields, whose resultant sum changes orientation in time, wherein said at least two time-dependent fields are at a non-zero angle with respect to each other.

5. The method of claim 4, wherein said angle is a 90 degree angle.

6. The method of claim 2, wherein said currents passed through said at least two coils comprise:

a first current passed through a first coil and a second current passed through a second coil such that said first current has a phase with respect to said second current.

7. The method of claim 6, wherein said phase of said first current with respect to said second current is a 90 degree phase.

8. The method of claim 2, wherein said first current is pulsed and wherein said second current is pulsed, wherein the number of said pulses of said first current and of said second current is at least one.

9. The method of claim 8, wherein said pulses of said first current and of said second current are of the same pulse rate, same wave pattern, same peak amplitude or combination thereof.

10. The method of claim 8, wherein said pulse of said first current comprises a first sine wave and said pulse of said second current comprises a second sine wave such that said second sine wave lags by one quarter of a cycle behind said first sine wave.

11. The method of claim 1, further comprising collecting or detecting an electric signal from said neuron or neurons.

12. The method of claim 1, wherein said neuron excitation comprises axonal excitation.

13. The method of claim 1, wherein said method is applied to a brain of a subject.

14. The method of claim 13, wherein said method is applied for diagnostics, treatment or combination thereof.

15. The method of claim 1, wherein said neuron excitation is applied to a neuron culture, and said culture to said neuron excitation is detected wherein said response is detected by imaging spectral changes in said culture.

16. The method of claim 1, wherein said rotating field excites the axons of said neurons, wherein the direction of the long axis of one axon creates a non-zero angle with respect to the direction of the long axis of a second axon.

17. The method of claim 1, wherein said rotating electric field excites at least the minimal number of neurons needed to generate a response in a neuron population, thereby generating a global response in said neuron population.

18. The method of claim 1, wherein said method excites axons regardless of axonal orientation.

19. A device for neuron excitation, said device comprising a set of at least two separate coils, said coils are independently driven, forming a rotating electric field, wherein the rotation of said rotating electric field is a result of vector summation of at least two time-dependant electric fields that are induced by at least two time-dependent magnetic field pulses, said pulses at least partially overlap in time.

20. The device of claim 19, wherein said at least two separate coils are driven with shifted phases of current in time.

21. The device of claim 20, wherein said currents passed through said at least two coils comprise:

a first current passed through a first coil and a second current passed through a second coil such that said first current has a phase with respect to said second current.

22. The device of claim 21, wherein said first current is pulsed and wherein said second current is pulsed, wherein the number of said pulses of said first current and of said second current is at least one.

23. The device of claim 22, wherein said pulses of said first current and of said second current are of the same pulse rate, same wave pattern, same peak amplitude, or combination thereof.

24. The device of claim 22, wherein said pulse of said first current comprises a first sine wave and said pulse of said second current comprises a second sine wave such that said second sine wave lags by one quarter of a cycle behind said first sine wave.

25. The device of claim 24, wherein said pulse of said first current comprises one period of said first sine wave and said pulse of said second current comprises one period of said second sine wave.

26. The device of claim 19, wherein said coils create at least two time-dependent electric fields, whose resultant sum changes orientation in time.

27. The device of claim 19, wherein said two coils are at an angle with respect to each other, and are perpendicular to each other.

28. The device of claim 19, further comprising a collector or a detector for collecting or detecting an electric signal from said neuron.

29. The device of claim 19, wherein said rotating field excites the axons of said neurons, wherein the direction of the long axis of one axon creates a non-zero angle with respect to the direction of the long axis of a second axon.

30. The device of claim 19, wherein said rotating electric field excites at least the minimal number of neurons needed to generate a response in a neuron population, thereby generating an electrical response in said neuron population, wherein the long axes of the axons of at least two of said neurons are not parallel.

31. The device of claim 19, wherein said coils are at a non-zero angle with respect to each other.

32. The device of claim 19, wherein said device excites axons regardless of axonal orientation.