Process for the preparation of 4-amino-3-chloro-5-fluoro-6-(substituted) picolinates

• US 9,067,890 B2
• Filed: 02/04/2014
• Issued: 06/30/2015
• Est. Priority Date: 01/25/2011
• Status: Expired due to Fees

• Current Assignee: Dow Agrosciences LLC (Corteva, Inc.)
• Original Assignee: Dow Agrosciences LLC (Corteva, Inc.)
• Inventors: Arndt, Kim E., Renga, James M., Zhu, Yuanming, Whiteker, Gregory T., Lowe, Christian T.
• Primary Examiner(s): NORTHINGTON DAVI, ZINNA
• Application Number:
  US14/171,791
• Publication Number:
  US 20140142317A1
• Time in Patent Office: 511 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: C07D 213/79 Acids; Esters
• CPC Class Codes: C07D 213/803 Processes of preparation
• CPC Class Codes: C07D 213/81 Amides; Imides
• CPC Class Codes: C07D 213/84 Nitriles

Abstract

4-Amino-3-chloro-5-fluoro-6-(substituted)picolinates are conveniently prepared from 3,4,5,6-tetrachloropicolinonitrile by a series of steps involving fluorine exchange, amination, halogen exchange and hydrolysis, esterification and transition metal assisted coupling.

Claims

1. A process for the preparation of a 4-amino-3-chloro-5-fluoro-6-(substituted)picolinate of the Formula I

2. The process of claim 1, wherein the 4-amino-3-chloro-5-fluoro-6-(substituted)picolinate of the Formula I is methyl 4-amino-3chloro-5-fluoro-6-(4-chloro-2-fluoro-3methoxy-phenyl)picolinate.