Targeting PD-1 variants for treatment of cancer
First Claim
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1. A method of treating a solid tumor;
- melanoma;
renal cell carcinoma;
non small-cell lung cancer;
bladder cancer;
Hodgkin'"'"'s lymphoma;
or gastric cancer in a human by targeting PD-1 in the human, the method comprising administering an antibody or antibody fragment to the human, wherein the antibody or antibody fragment specifically binds a PD-1 encoded by a PD-1 nucleotide sequence comprising a SNP selected from the group consisting of;
rs7568402;
rs28699177;
rs28542728;
rs118117097;
rs28570544;
rs118027315;
rs191919871;
rs6707556;
rs142909968;
rs36084323;
rs10204225;
rs11568821;
rs2227981; and
rs2227982;
wherein the antibody or antibody fragment comprises a human gamma-4 heavy chain constant region that comprises an amino acid selected from the group consisting of;
a Leu at position 189 shown in SEQ ID NO;
73 and an Arg at position 289 shown in SEQ ID NO;
73; and
wherein said human comprises(i) an IGHG4*01 human heavy chain constant region gene segment, or the human expresses antibodies comprising human gamma-4 heavy chain constant regions comprising said selected amino acid; and
(ii) a PD-1 nucleotide sequence comprising said selected SNP.
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Abstract
The invention relates to human targets of interest (TOI), anti-TOI ligands, kits compositions and method.
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Citations
15 Claims
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1. A method of treating a solid tumor;
- melanoma;
renal cell carcinoma;
non small-cell lung cancer;
bladder cancer;
Hodgkin'"'"'s lymphoma;
or gastric cancer in a human by targeting PD-1 in the human, the method comprising administering an antibody or antibody fragment to the human, wherein the antibody or antibody fragment specifically binds a PD-1 encoded by a PD-1 nucleotide sequence comprising a SNP selected from the group consisting of;rs7568402;
rs28699177;
rs28542728;
rs118117097;
rs28570544;
rs118027315;
rs191919871;
rs6707556;
rs142909968;
rs36084323;
rs10204225;
rs11568821;
rs2227981; and
rs2227982;wherein the antibody or antibody fragment comprises a human gamma-4 heavy chain constant region that comprises an amino acid selected from the group consisting of; a Leu at position 189 shown in SEQ ID NO;
73 and an Arg at position 289 shown in SEQ ID NO;
73; andwherein said human comprises (i) an IGHG4*01 human heavy chain constant region gene segment, or the human expresses antibodies comprising human gamma-4 heavy chain constant regions comprising said selected amino acid; and (ii) a PD-1 nucleotide sequence comprising said selected SNP. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
- melanoma;
Specification