Non-linear rotation rates of remotely driven particles and uses thereof
First Claim
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1. A method of detecting the presence of an analyte in a sample, comprising:
- contacting a magnetic particle with said sample under conditions such that said particle interacts with said analyte;
rotating said magnetic particle using an external rotating magnetic field applied to the sample;
measuring the non-linear rotation rate of said magnetic particle during application of the rotating magnetic field; and
determining the presence of said analyte in said sample when said non-linear rotation rate is altered relative to a rotational rate of the magnetic particle in the absence of said sample.
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Abstract
The present invention relates to biological sensors. In particular, the present invention relates to the use of remotely driven nonlinear rotation of particles (e.g., magnetic particles) for detection of cells such as microorganisms (e.g., bacteria and viruses). The present invention further relates to the use of remotely driven nonlinear rotation of particles for measurement of physical properties of a solution (e.g., viscosity).
73 Citations
31 Claims
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1. A method of detecting the presence of an analyte in a sample, comprising:
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contacting a magnetic particle with said sample under conditions such that said particle interacts with said analyte; rotating said magnetic particle using an external rotating magnetic field applied to the sample; measuring the non-linear rotation rate of said magnetic particle during application of the rotating magnetic field; and determining the presence of said analyte in said sample when said non-linear rotation rate is altered relative to a rotational rate of the magnetic particle in the absence of said sample. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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25. A method for measuring changes in the number and/or size of cells bound to magnetic particles, the method comprising:
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contacting magnetic particles with a solution comprising cells under conditions such that said magnetic particles bind to said cells; rotating said magnetic particles using an external rotating magnetic field; and during application of the rotating magnetic field, measuring changes in the non-linear rotation rate of said magnetic particles over time, wherein said non-linear rotation rate is altered in response to change in the number and/or size of said cells bound to said magnetic particles. - View Dependent Claims (26, 27, 28, 29, 30, 31)
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Specification