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Compositions and methods for therapeutic delivery with frozen particles

  • US 9,072,688 B2
  • Filed: 10/31/2008
  • Issued: 07/07/2015
  • Est. Priority Date: 10/31/2008
  • Status: Active Grant
First Claim
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1. A therapeutic composition, comprising:

  • one or more frozen hydrogen oxide particles less than 200 micrometers in size and coated with a specific cell receptor;

    the one or more frozen hydrogen oxide particles each further defining at least two cavities, the first cavity containing at least one anti-tumor agent, including at least one of an alkylating agent, antimetabolite, anthracycline, plant alkaloid, topoisomerase inhibitor, monoclonal antibody, or tyrosine kinase inhibitor;

    and the second cavity containing one or more of a cytokine, chemokine, anti-angiogenic factor, anti-inflammatory agent, vaccine, hormone, or radioactive agent.

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